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Polycystic Ovary Syndrome (PCOS) or hyperandrogenic anovulation is a common metabolic disorder in women which may leads to infertility. The condition determined with more than 10 small ovarian cysts of diameter ranging from 2-9mm. Excess gonadotropin secretion in PCOS women produce fluctuation in LH level which disturbs the LH: FSH ratio in body. Modulation of FSH receptors with plant phytoconstituents attenuate the production of FSH which gradually reduce the activity of LH and reduce the PCOS activity. Nisajeerakadichoornam; a novel ayurvedic formulation prepared with four plant parts; fruit of Foeniculumvulgare, bulb of Allilumsativum, seed of Macrotylomauniflorum and rhizomes of Curcuma longa. The plant parts are cleaned and dried properly. They are finely powdered separately, sieved, accurately weighed and then all mixed together. The powder pass through 80 mesh sieves. It should not adhere together or become moist. The finer powder has better therapeutic value and expected to be effective towards PCOS. In the present study, insilico evaluation of FSH receptor (4MQW) and insulin receptor (3BU3) by phytoconstituents present in the choornam were studied using PyRx, PyMOL, Open babel software. ADME parameters are evaluated with SWISS ADME software. The results show that all the phytoconstituents possess binding energy ranges from -5.2kcal/mol to -8.8kcal/mol with the receptor. In addition, the drug likeness of the constituents present in the choornam; allicin, anethol, cucumine and inositol evaluate through analyzing the ADME properties. [ABSTRACT FROM AUTHOR]