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22 results on '"Blom, Kim"'

1. Prevalence of SARS-CoV-2 infections among Swedish healthcare workers on duty in December 2023

Author

Aguilera, Katherina, Bladh, Oscar, Marking, Ulrika, Norin, Nina Greilert, Rihani, Ali, Ujvari, Dorina, Ning, Frank Chenfei, Klingström, Jonas, Havervall, Sebastian, Aberg, Mikael, Blom, Kim, Alm, Jessica J., Thalin, Charlotte, Aguilera, Katherina, Bladh, Oscar, Marking, Ulrika, Norin, Nina Greilert, Rihani, Ali, Ujvari, Dorina, Ning, Frank Chenfei, Klingström, Jonas, Havervall, Sebastian, Aberg, Mikael, Blom, Kim, Alm, Jessica J., and Thalin, Charlotte

Published
2024
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2. Comparison of SARS-CoV-2 spike-specific IgA and IgG in nasal secretions, saliva and serum

Author

Bladh, Oscar, Aguilera, Katherina, Marking, Ulrika, Kihlgren, Martha, Norin, Nina Greilert, Smed-Sorensen, Anna, Chen, Margaret Sallberg, Klingström, Jonas, Blom, Kim, Russell, Michael W., Havervall, Sebastian, Thalin, Charlotte, Aberg, Mikael, Bladh, Oscar, Aguilera, Katherina, Marking, Ulrika, Kihlgren, Martha, Norin, Nina Greilert, Smed-Sorensen, Anna, Chen, Margaret Sallberg, Klingström, Jonas, Blom, Kim, Russell, Michael W., Havervall, Sebastian, Thalin, Charlotte, and Aberg, Mikael

Abstract

Introduction: Several novel vaccine platforms aim at mucosal immunity in the respiratory tract to block SARS-CoV-2 transmission. Standardized methods for mucosal sample collection and quantification of mucosal antibodies are therefore urgently needed for harmonized comparisons and interpretations across mucosal vaccine trials and real-world data. Methods: Using commercial electrochemiluminescence antibody panels, we compared SARS-CoV-2 spike-specific IgA and IgG in paired saliva, nasal secretions, and serum from 1048 healthcare workers with and without prior infection. Results: Spike-specific IgA correlated well in nasal secretions and saliva (r>0.65, p<0.0001), but the levels were more than three-fold higher in nasal secretions as compared to in saliva (p<0.01). Correlations between the total population of spike-specific IgA and spike-specific secretory IgA (SIgA) were significantly stronger (p<0.0001) in nasal secretions (r=0.96, p<0.0001) as opposed to in saliva (r=0.77, p<0.0001), and spike-specific IgA correlated stronger (p<0.0001) between serum and saliva (r=0.73, p<0.001) as opposed to between serum and nasal secretions (r=0.54, p<0.001), suggesting transudation of monomeric spike specific IgA from the circulation to saliva. Notably, spike-specific SIgA had a markedly higher SARS-CoV-2 variant cross-binding capacity as compared to the total population of spike specific IgA and IgG in both nasal secretions, saliva and serum, (all p<0.0001), which emphasizes the importance of taking potential serum derived monomeric IgA into consideration when investigating mucosal immune responses. Discussion: Taken together, although spike-specific IgA can be reliably measured in both nasal secretions and saliva, our findings imply an advantage of higher levels and likely also a larger proportion of SIgA in nasal secretions as compared to in saliva. We further corroborate the superior variant cross-binding, Funding Agencies|Jonas and Christina at Jochnick Foundation; Region Stockholm; SciLifeLab; Knut and Alice Wallenberg Foundation; Leif Lundblad Family Foundation; Swedish Research Council; Swedish Heart and Lung Foundation; Bill & Melinda Gates Foundation; Center for Innovative Medicine

Published
2024
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3. High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022

Author

Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, Klingström, Jonas, Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, and Klingström, Jonas

Abstract

We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvacci-nated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more patho-genic variants., Funding Agencies|Swedish Armed Forces - Public Health Agency of Sweden [S2020/0281/FS]; Public Health Agency of Sweden [S2020/0281/FS, S2020/08532 FS]

Published
2023
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5. High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022

Author

Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, Klingström, Jonas, Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, and Klingström, Jonas

Abstract

We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvacci-nated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more patho-genic variants., Funding Agencies|Swedish Armed Forces - Public Health Agency of Sweden [S2020/0281/FS]; Public Health Agency of Sweden [S2020/0281/FS, S2020/08532 FS]

Published
2023
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7. High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022

Author

Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, Klingström, Jonas, Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, and Klingström, Jonas

Abstract

We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvacci-nated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more patho-genic variants., Funding Agencies|Swedish Armed Forces - Public Health Agency of Sweden [S2020/0281/FS]; Public Health Agency of Sweden [S2020/0281/FS, S2020/08532 FS]

Published
2023
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8. Rapid emergence of omicron sublineages expressing spike protein R346T

Author

Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, Blom, Kim, Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, and Blom, Kim

Published
2023
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10. Rapid emergence of omicron sublineages expressing spike protein R346T

Author

Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, Blom, Kim, Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, and Blom, Kim

Published
2023
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11. Rapid emergence of omicron sublineages expressing spike protein R346T

Author

Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, Blom, Kim, Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, and Blom, Kim

Published
2023
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12. Rapid emergence of omicron sublineages expressing spike protein R346T

Author

Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, Blom, Kim, Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, and Blom, Kim

Published
2023
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14. SARS-CoV-2-related mortality decrease in nursing home residents given multiple COVID-19 boosters

Author

Blom, Kim, Fjallstrom, Peter, Molnar, Christian, Aberg, Mikael, Vikstrom, Linnea, Wigren-Bystrom, Julia, Bennet, Louise, Widerstrom, Micael, Rasmussen, Gunlog, Klingström, Jonas, Forsell, Mattias N. E., Johansson, Anders F., Blom, Kim, Fjallstrom, Peter, Molnar, Christian, Aberg, Mikael, Vikstrom, Linnea, Wigren-Bystrom, Julia, Bennet, Louise, Widerstrom, Micael, Rasmussen, Gunlog, Klingström, Jonas, Forsell, Mattias N. E., and Johansson, Anders F.

Published
2023
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15. Mucosal IgA protects against BQ.1 and BQ.1.1 infection

Author

Marking, Ulrika, Bladh, Oscar, Havervall, Sebastian, Greilert-Norin, Nina, Gordon, Max, Alm, Jessica J., Blom, Kim, Aberg, Mikael, Klingström, Jonas, Thalin, Charlotte, Marking, Ulrika, Bladh, Oscar, Havervall, Sebastian, Greilert-Norin, Nina, Gordon, Max, Alm, Jessica J., Blom, Kim, Aberg, Mikael, Klingström, Jonas, and Thalin, Charlotte

Published
2023
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16. 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection

Author

Marking, Ulrika, Bladh, Oscar, Havervall, Sebastian, Svensson, Julia, Greilert-Norin, Nina, Aguilera, Katherina, Kihlgren, Martha, Salomonsson, Ann-Cristin, Mansson, Maja, Gallini, Radiosa, Kriegholm, Cecilia, Bacchus, Philip, Hober, Sophia, Gordon, Max, Blom, Kim, Smed-Sorensen, Anna, Aberg, Mikael, Klingström, Jonas, Thalin, Charlotte, Marking, Ulrika, Bladh, Oscar, Havervall, Sebastian, Svensson, Julia, Greilert-Norin, Nina, Aguilera, Katherina, Kihlgren, Martha, Salomonsson, Ann-Cristin, Mansson, Maja, Gallini, Radiosa, Kriegholm, Cecilia, Bacchus, Philip, Hober, Sophia, Gordon, Max, Blom, Kim, Smed-Sorensen, Anna, Aberg, Mikael, Klingström, Jonas, and Thalin, Charlotte

Published
2023
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17. High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022

Author

Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, Klingström, Jonas, Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, and Klingström, Jonas

Abstract

We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvacci-nated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more patho-genic variants., Funding Agencies|Swedish Armed Forces - Public Health Agency of Sweden [S2020/0281/FS]; Public Health Agency of Sweden [S2020/0281/FS, S2020/08532 FS]

Published
2023
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18. Rapid emergence of omicron sublineages expressing spike protein R346T

Author

Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, Blom, Kim, Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, and Blom, Kim

Published
2023
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19. Rapid emergence of omicron sublineages expressing spike protein R346T

Author

Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, Blom, Kim, Groenheit, Ramona, Galanis, Ilias, Sonden, Klara, Sperk, Maike, Movert, Elin, Bacchus, Philip, Efimova, Tatiana, Petersson, Lina, Rapp, Marie, Sahlen, Viktoria, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Klingström, Jonas, and Blom, Kim

Published
2023
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21. High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022

Author

Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, Klingström, Jonas, Groenheit, Ramona, Bacchus, Philip, Galanis, Ilias, Sonden, Klara, Bujila, Ioana, Efimova, Tatiana, Garli, Fredrik, Lindsjo, Oskar Karlsson, Mansjo, Mikael, Movert, Elin, Pettke, Aleksandra, Rapp, Marie, Sperk, Maike, Soderholm, Sandra, Asin, Karin Valentin, Zanetti, Sarah, Karlberg, Maria Lind, Brave, Andreas, Blom, Kim, and Klingström, Jonas

Abstract

We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvacci-nated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more patho-genic variants., Funding Agencies|Swedish Armed Forces - Public Health Agency of Sweden [S2020/0281/FS]; Public Health Agency of Sweden [S2020/0281/FS, S2020/08532 FS]

Published
2023
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22. Mucosal and Serum Antibodies 3 Weeks after Symptomatic BA.2.86 Infection

Author

Bladh, Oscar, Greilert-Norin, Nina, Havervall, Sebastian, Marking, Ulrika, Aguilera, Katherina, Alm, Jessica J., Blom, Kim, Aberg, Mikael, Klingström, Jonas, Thalin, Charlotte, Bladh, Oscar, Greilert-Norin, Nina, Havervall, Sebastian, Marking, Ulrika, Aguilera, Katherina, Alm, Jessica J., Blom, Kim, Aberg, Mikael, Klingström, Jonas, and Thalin, Charlotte

Abstract

Response to BA.2.86 Infection after Vaccination Infection with the BA.2.86 subvariant in a vaccinated and previously infected person yielded a strong induction of mucosal IgA binding to the wild-type and BA.5 spike (factor change, 3.6 and 3.4, respectively)., Funding Agencies|Jonas and Christina af Jochnick Foundation; Region Stockholm; SciLifeLab through the Knut and Alice Wallenberg Foundation

Published
2023
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