1. Psychometric Properties of a Generic, Patient-Centred Palliative Care Outcome Measure of Symptom Burden for People with Progressive Long Term Neurological Conditions
- Author
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Wei Gao, Vincent Crosby, Andrew Wilcock, Rachael Burman, Eli Silber, Nilay Hepgul, K Ray Chaudhuri, Irene J Higginson, and OPTCARE Neuro trial
- Subjects
Questionnaires ,Male ,Research Validity ,Palliative care ,Psychometrics ,Physiology ,Social Sciences ,Pathology and Laboratory Medicine ,Severity of Illness Index ,0302 clinical medicine ,Patient-Centered Care ,Outcome Assessment, Health Care ,Medicine and Health Sciences ,Psychology ,030212 general & internal medicine ,Longitudinal Studies ,education.field_of_study ,Multidisciplinary ,Movement Disorders ,Minimal clinically important difference ,Palliative Care ,Neurodegenerative Diseases ,Parkinson Disease ,Nausea ,Research Assessment ,Middle Aged ,Neurology ,Research Design ,Medicine ,Female ,Supranuclear Palsy, Progressive ,Research Article ,medicine.medical_specialty ,Multiple Sclerosis ,Vomiting ,Science ,Population ,Concurrent validity ,Immunology ,Research and Analysis Methods ,Autoimmune Diseases ,03 medical and health sciences ,Physical medicine and rehabilitation ,Signs and Symptoms ,Cronbach's alpha ,Diagnostic Medicine ,medicine ,Humans ,education ,Aged ,Survey Research ,business.industry ,Discriminant validity ,Construct validity ,Biology and Life Sciences ,Multiple System Atrophy ,Demyelinating Disorders ,Health Care ,Cross-Sectional Studies ,Physical therapy ,Clinical Immunology ,Clinical Medicine ,business ,Physiological Processes ,030217 neurology & neurosurgery - Abstract
BackgroundThere is no standard palliative care outcome measure for people with progressive long term neurological conditions (LTNC). This study aims to determine the psychometric properties of a new 8-item palliative care outcome scale of symptom burden (IPOS Neuro-S8) in this population.Data and methodsData were merged from a Phase II palliative care intervention study in multiple sclerosis (MS) and a longitudinal observational study in idiopathic Parkinson's disease (IPD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). The IPOS Neuro-S8 was assessed for its data quality, score distribution, ceiling and floor effects, reliability, factor structure, convergent and discriminant validity, concurrent validity with generic (Palliative care Outcome Scale) and condition specific measures (Multiple Sclerosis Impact Scale; Non-motor Symptoms Questionnaire; Parkinson's Disease Questionnaire), responsiveness and minimally clinically important difference.ResultsOf the 134 participants, MS patients had a mean Extended Disability Status Scale score 7.8 (SD = 1.0), patients with an IPD, MSA or PSP were in Hoehn & Yahr stage 3-5. The IPOS Neuro-S8 had high data quality (2% missing), mean score 8 (SD = 5; range 0-32), no ceiling effects, borderline floor effects, good internal consistency (Cronbach's α = 0.7) and moderate test-retest reliability (intraclass coefficient = 0.6). The results supported a moderately correlated two-factor structure (Pearson's r = 0.5). It was moderately correlated with generic and condition specific measures (Pearson's r: 0.5-0.6). There was some evidence for discriminant validity in IPD, MSA and PSP (p = 0.020), and for good responsiveness and longitudinal construct validity.ConclusionsIPOS Neuro-S8 shows acceptable to promising psychometric properties in common forms of progressive LTNCs. Future work needs to confirm these findings with larger samples and its usefulness in wider disease groups.
- Published
- 2016