1. Feasibility of β-Sheet Breaker Peptide-H102 Treatment for Alzheimer's Disease Based on β-Amyloid Hypothesis.
- Author
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Lin, Lai-xiang, Bo, Xiang-yu, Tan, Yuan-zhen, Sun, Feng-xian, Song, Ming, Zhao, Juan, Ma, Zhi-hong, Li, Mei, Zheng, Kai-jun, and Xu, Shu-mei
- Subjects
PEPTIDES ,ALZHEIMER'S disease treatment ,NEUROTOXICOLOGY ,AMYLOID beta-protein precursor ,APOPTOSIS ,MENTAL health - Abstract
β-amyloid hypothesis is the predominant hypothesis in the study of pathogenesis of Alzheimer's disease. This hypothesis claims that aggregation and neurotoxic effects of amyloid β (Aβ) is the common pathway in a variety of etiological factors for Alzheimer's disease. Aβ peptide derives from amyloid precursor protein (APP). β-sheet breaker peptides can directly prevent and reverse protein misfolding and aggregation in conformational disorders. Based on the stereochemical structure of Aβ1-42 and aggregation character, we had designed a series of β-sheet breaker peptides in our previous work and screened out a 10-residue peptide β-sheet breaker peptide, H102. We evaluated the effects of H102 on expression of P-tau, several associated proteins, inflammatory factors and apoptosis factors, and examined the cognitive ability of APP transgenic mice by behavioral test. This study aims to validate the β-amyloid hypothesis and provide an experimental evidence for the feasibility of H102 treatment for Alzheimer's disease. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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