1. Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis
- Author
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Hengxing Zhou, Liu Jun, Zhongju Shi, Bin Pan, Shiqing Feng, Xue Yao, Lu Lu, and Yi Kang
- Subjects
Male ,Critical Care and Emergency Medicine ,Physiology ,Osteoporosis ,lcsh:Medicine ,Cochrane Library ,Biochemistry ,law.invention ,0302 clinical medicine ,Mathematical and Statistical Techniques ,Randomized controlled trial ,law ,Teriparatide ,Medicine and Health Sciences ,lcsh:Science ,Connective Tissue Diseases ,Trauma Medicine ,Randomized Controlled Trials as Topic ,Fracture Healing ,030222 orthopedics ,Multidisciplinary ,Parathyroid Hormone ,Research Design ,Bone Fracture ,Meta-analysis ,Physical Sciences ,Female ,Traumatic Injury ,Statistics (Mathematics) ,medicine.drug ,Research Article ,medicine.medical_specialty ,Drug Research and Development ,Clinical Research Design ,Pain ,030209 endocrinology & metabolism ,Bone healing ,Research and Analysis Methods ,03 medical and health sciences ,Rheumatology ,Adverse Reactions ,Tissue Repair ,medicine ,Humans ,Clinical Trials ,Statistical Methods ,Adverse effect ,Pharmacology ,business.industry ,lcsh:R ,Biology and Life Sciences ,Bone fracture ,medicine.disease ,Hormones ,Randomized Controlled Trials ,Physical therapy ,lcsh:Q ,Adverse Events ,Clinical Medicine ,business ,Physiological Processes ,Mathematics ,Meta-Analysis - Abstract
Purpose Nowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn’t come to an agreement. This meta-analysis was conducted to evaluate the effectiveness of teriparatide for fracture healing. Methods We searched PubMed, the Cochrane Library, and Embase in August 2016 for randomized controlled trials (RCTs) which concerned the treatment of teriparatide for fracture healing. Results Finally, a total of 380 patients were randomly assigned in the 5 trials included in this meta-analysis. There was a significant effectiveness with regards to function improvement in patients following fracture, however, there was no significant effectiveness with regards to time of radiographic fracture healing, fracture healing rate and reduction in pain. Conclusions This analysis showed that administration of teriparatide following fracture lacked the effectiveness for fracture healing. Moreover, teriparatide administration had no apparent adverse effects. These results should be interpreted with caution because of some clear limitations. If we want to confirm whether teriparatide improves fracture healing, more high-quality randomized controlled trials are needed.
- Published
- 2016