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Your search keyword '"C, Marzo"' showing total 2 results
Start Over Author "C, Marzo" Publisher public library of science
2 results on '"C, Marzo"'

1. Human mobility at Tell Atchana (Alalakh), Hatay, Turkey during the 2nd millennium BC: integration of isotopic and genomic evidence

Author

Ingman, Tara, Eisenmann, S.; Skourtanioti, E.; Akar, M.; Ilgner, J.; Gnecchi Ruscone, G. A.; le Roux, P.; Shafiq, R.; Neumann, G. U.; Keller, M.; Freund, C.; Marzo, S.; Lucas, M.; Krause, J.; Roberts, P.; Yener, K. A.; Stockhammer, P. W., Ingman, Tara, and Eisenmann, S.; Skourtanioti, E.; Akar, M.; Ilgner, J.; Gnecchi Ruscone, G. A.; le Roux, P.; Shafiq, R.; Neumann, G. U.; Keller, M.; Freund, C.; Marzo, S.; Lucas, M.; Krause, J.; Roberts, P.; Yener, K. A.; Stockhammer, P. W.

Abstract

The Middle and Late Bronze Age, a period roughly spanning the 2(nd) millennium BC (ca. 2000-1200 BC) in the Near East, is frequently referred to as the first 'international age', characterized by intense and far-reaching contacts between different entities from the eastern Mediterranean to the Near East and beyond. In a large-scale tandem study of stable isotopes and ancient DNA of individuals excavated at Tell Atchana (Alalakh, located in Hatay, Turkey), we explored the role of mobility at the capital of a regional kingdom, named Mukish during the Late Bronze Age, which spanned the Amuq Valley and some areas beyond. We generated strontium and oxygen isotope data from dental enamel for 53 individuals and 77 individuals, respectively, and added ancient DNA data of 10 newly sequenced individuals to a dataset of 27 individuals published in 2020. Additionally, we improved the DNA coverage of one individual from this 2020 dataset. The DNA data revealed a very homogeneous gene pool. This picture of an overwhelmingly local ancestry was consistent with the evidence of local upbringing in most of the individuals indicated by the isotopic data, where only five were found to be non-local. High levels of contact, trade, and exchange of ideas and goods in the Middle and Late Bronze Ages, therefore, seem not to have translated into high levels of individual mobility detectable at Tell Atchana.

Published
2021

2. Efficacy of Sphincter Control Training (SCT) in the treatment of premature ejaculation, a new cognitive behavioral approach: A parallel-group randomized, controlled trial

Author

Juan C. Marzo, Jesús Rodríguez, and José A. Piqueras

Subjects
Male, Physiology, medicine.medical_treatment, 030232 urology & nephrology, Social Sciences, law.invention, Treatment and control groups, 0302 clinical medicine, Learning and Memory, Randomized controlled trial, law, Medicine and Health Sciences, Medicine, Psychology, 030219 obstetrics & reproductive medicine, Multidisciplinary, Pharmaceutics, Cognitive behavioral therapy, medicine.symptom, Research Article, Medical Ethics, Adult, medicine.medical_specialty, Drug Research and Development, Ejaculation, Science, Placebo, Research and Analysis Methods, 03 medical and health sciences, Drug Therapy, Adverse Reactions, Premature ejaculation, Mental Health and Psychiatry, Learning, Humans, Clinical Trials, Premature Ejaculation, Adverse effect, Pharmacology, Behavior, Cognitive Behavioral Therapy, business.industry, Urethral sphincter, Cognitive Psychology, Biology and Life Sciences, Randomized Controlled Trials, Psychotherapy, Physical therapy, Cognitive Science, Clinical Medicine, business, Physiological Processes, Mental Health Therapies, Neuroscience
Abstract

IntroductionCurrent evidence suggests that Cognitive Behavioral therapy (CBT) has a limited role in the contemporary management of premature ejaculation (PE).AimThe aim of this study was to determine the efficacy of a new CBT for the PE called Sphincter Control Training (SCT) in combination with a masturbation aid device.MethodsThe present study included 35 patients' that met diagnostic criteria for PE including intravaginal ejaculatory latency time (IELT) of ≤2 minutes and had a Premature Ejaculation Diagnostic Tool (PEDT) score ≥11. Participants completed all phases of a randomized controlled clinical study with a parallel group design, which was approved by the Ethical Committee of the Hospital Morales Meseguer of Murcia (Spain).The two treatment groups completed SCT over 7 weeks. The SCT consists of four different exercises and an educational session. Its objective is to provide patients with greater knowledge, awareness, and control of the external urethral sphincter. The only difference between groups was the use of a masturbation aid device called Flip Zero (TFZ-001) from the Japanese company Tenga Co., Ltd.OutcomesThe main measure was the "fold increase" (FI) of the IELT, which was calculated using the geometric mean pre-treatment and post-treatment. In addition, Premature Ejaculation Profile PE was used as a secondary measure.ResultsThe geometric mean of the measurements corresponding to the 7 weeks of treatment was calculated, and both groups were compared by means of an ANCOVA test, finding a statistically significant difference (F: 10.51, 1; p = .003) in the increase experienced by subjects in the group with the device (GWD) mean = 166.63, SD = 106.54) compared with that experienced by subjects in the group without device (GWtD) (mean = 86.99, SD = 59.98).Using Student's t-test, the Fold increase (FI) corresponding to both groups were compared. The results showed statistically significant differences (p = .008) between the measurements corresponding to the GWtD (1.38 (0.50)) and those relative to the GWD (2.69 (1.81)).Clinical implicationsThe FI in the GWD at the end of the trial allow us to consider this new CBT as a potential and viable PE treatment alternative. No side effects were observed in either treatment group and it required little therapeutic input and no partner involvement.Strengths & limitationsThe main limitation of this study is the lack of a 3- to 6-month follow-up of the treatment and placebo control.ConclusionsThis SCT exercise program combined with the use of a masturbation device shows promise because has numerous advantages in relation to current recommended treatments in patients with PE.

Published
2019

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