1. Intravoxel Incoherent Motion Diffusion Weighted MR Imaging at 3.0 T: Assessment of Steatohepatitis and Fibrosis Compared with Liver Biopsy in Type 2 Diabetic Patients.
- Author
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Parente, Daniella Braz, Paiva, Fernando Fernandes, Oliveira Neto, Jaime Araújo, Machado-Silva, Lilian, Figueiredo, Fatima Aparecida Ferreira, Lanzoni, Valeria, Campos, Carlos Frederico Ferreira, do Brasil, Pedro Emmanuel Alvarenga Americano, Gomes, Marilia de Brito, Perez, Renata de Mello, and Rodrigues, Rosana Souza
- Subjects
MAGNETIC resonance imaging ,HEPATIC fibrosis ,LIVER biopsy ,FATTY liver ,COMPARATIVE studies - Abstract
Objective: To evaluate the capability of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) to assess steatohepatitis and fibrosis determined by histopathology in type 2 diabetic patients. Methods: Fifty-nine type 2 diabetic patients (49 women, 10 men; mean age, 54 ± 9 years) were submitted to liver biopsy for the evaluation of non-alcoholic fatty liver disease (NAFLD) and underwent DWI on a 3.0T MR system using 10 b values. Institutional approval and patient consent were obtained. Pure molecular-based (D), perfusion-related (D*), and vascular fraction (f) were calculated using a double exponential model and least squares curve fitting. D, D*, and f were compared between patients with and without steatohepatitis and between patients with and without fibrosis. The variables were compared by using the Ranksum test and Student t-test. Results: Steatohepatitis was observed in 22 patients and fibrosis in 16 patients. A lower D median (0.70 s/mm
2 vs. 0.83 s/mm2 , p<0.05) and a lower D* median (34.39 s/mm2 vs. 45.23 s/mm2 , p<0.05) were observed among those with steatohepatitis. A lower D median (0.70 s/mm2 vs. 0.82 s/mm2 , p<0.05) and a lower D* median (35.01 s/mm2 vs. 44.76 s/mm2 , p=0.05) were also observed among those with fibrosis. Conclusion: IVIM-DWI has the potential to aid in the characterization of steatohepatitis and fibrosis. [ABSTRACT FROM AUTHOR]- Published
- 2015
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