1. Poststroke Depression and Risk of Recurrent Stroke at 1 Year in a Chinese Cohort Study
- Author
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Juan Zhou, Yilong Wang, Ying Bai, Xing Quan Zhao, Xin-yu Sun, Yongjun Wang, Yuzhi Shi, Xin Yu, Chun Xue Wang, Huai Wu Yuan, Ning Zhang, Zhao Rui Liu, Yong Zhou, and Tong Zhang
- Subjects
Male ,Pediatrics ,Health Screening ,Multivariate analysis ,Non-Clinical Medicine ,Psychopharmacology ,Epidemiology ,lcsh:Medicine ,Cardiovascular ,Cohort Studies ,Recurrence ,Risk Factors ,Clinical Epidemiology ,Longitudinal Studies ,Prospective Studies ,lcsh:Science ,Stroke ,Depression (differential diagnoses) ,Psychiatry ,Multidisciplinary ,Depression ,musculoskeletal, neural, and ocular physiology ,Clinical Pharmacology ,Follow up studies ,Middle Aged ,Antidepressive Agents ,Hemorrhagic Stroke ,Mental Health ,Neurology ,Observational Studies ,Medicine ,Regression Analysis ,Female ,Public Health ,Alcohol consumption ,psychological phenomena and processes ,Cohort study ,Research Article ,medicine.medical_specialty ,Drugs and Devices ,China ,Clinical Research Design ,Cerebrovascular Diseases ,Neuropharmacology ,Asian People ,Recurrent stroke ,Diabetes mellitus ,mental disorders ,medicine ,Humans ,cardiovascular diseases ,Cardiovascular Disease Epidemiology ,Ischemic Stroke ,Health Care Policy ,business.industry ,Mood Disorders ,Pharmacoepidemiology ,lcsh:R ,Health Risk Analysis ,medicine.disease ,nervous system ,Multivariate Analysis ,Physical therapy ,lcsh:Q ,business ,Follow-Up Studies - Abstract
Background Studies show that poststroke depression (PSD) increases mortality risk at 1 year. However, whether PSD increases the risk of recurrent stroke at 1 year remains unclear. This study was to investigate whether PSD at 2 weeks following a stroke could increase risk of recurrent stroke at 1 year. Methods and Results This was a multi-centered prospective cohort study. A total of 2306 patients with acute stroke were enrolled in our study. PSD was diagnosed according to the criteria set by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). The outcomes of recurrent stroke were followed up via face-to-face or phone interview. A total of 1713 patients had complete follow-up data, with 481 (28.1%) cases of PSD and 158 (9.2%) cases of cumulative recurrent stroke at 1 year. Multivariate logistic regression analysis showed a 49% increase of OR of recurrent stroke at 1 year in patients with PSD, compared to patients without PSD following a stroke (OR = 1.49, 95%CI: 1.03–2.15). There was no significant correlation between anti-depressant drugs and the risk of recurrent stroke at 1 year following a stroke (OR = 1.96, 95%: CI 0.95–4.04). Conclusions Based on the DSM-IV diagnostic criteria, nearly 3 out of 10 hospitalized stroke patients in China were diagnosed with PSD at 2 weeks following a stroke. PSD is associated with a higher risk of recurrent stroke at 1 year. Our study did not find benefit of anti-depressant drugs in reducing such risk.
- Published
- 2012