1. Effect of body tissue composition on the outcome of patients with metastatic non-small cell lung cancer treated with PD-1/PD-L1 inhibitors.
- Author
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Makrakis, Dimitrios, Rounis, Konstantinos, Tsigkas, Alexandros-Pantelis, Georgiou, Alexandra, Galanakis, Nikolaos, Tsakonas, George, Ekman, Simon, Papadaki, Chara, Monastirioti, Alexia, Kontogianni, Meropi, Gioulbasanis, Ioannis, Mavroudis, Dimitris, and Agelaki, Sofia
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NON-small-cell lung carcinoma ,BODY composition ,SARCOPENIA ,PROGRAMMED cell death 1 receptors ,PROGRAMMED death-ligand 1 ,IMMUNE checkpoint inhibitors - Abstract
Obesity and sarcopenia have been reported to affect outcomes in patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs). We analyzed prospective data from 52 patients with non-oncogene driven metastatic NSCLC treated with ICIs. Body tissue composition was calculated by measuring the fat and muscle densities at the level of 3
rd lumbar vertebra in each patient computed tomography scan before ICI initiation using sliceOmatic tomovision. We converted the densities to indices [Intramuscular Fat Index (IMFI), Visceral Fat Index (VFI), Subcutaneous Fat Index (SFI), Lumbar Skeletal Muscle Index (LSMI)] by dividing them by height in meters squared. Patients were dichotomized based on their baseline IMFI, VFI and SFI according to their gender-specific median value. The cut-offs that were set for LMSI values were 55 cm2 /m2 for males and 39 cm2 /m2 for females. SFI distribution was significantly higher (p = 0.040) in responders compared to non-responders. None of the other variables affected response rates. Low LSMI HR: 2.90 (95% CI: 1.261–6.667, p = 0.012) and low SFI: 2.20 (95% CI: 1.114–4.333, p = 0.023) values predicted for inferior OS. VFI and IMFI values did not affect survival. Subcutaneous adipose and skeletal muscle tissue composition significantly affected immunotherapy outcomes in our cohort. [ABSTRACT FROM AUTHOR]- Published
- 2023
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