1. Differentiation of Malignant and Benign Incidental Breast Lesions Detected by Chest Multidetector-Row Computed Tomography: Added Value of Quantitative Enhancement Analysis
- Author
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Tsun-Hou Chang, Hsian-He Hsu, Kai-Hsiung Ko, Chi-Ming Chu, Yu-Ching Chou, Wei-Chou Chang, and Yu-Pang Lin
- Subjects
Physiology ,lcsh:Medicine ,Contrast Media ,Pathology and Laboratory Medicine ,030218 nuclear medicine & medical imaging ,Diagnostic Radiology ,0302 clinical medicine ,Breast Tumors ,Medicine and Health Sciences ,Medicine ,lcsh:Science ,Tomography ,Aged, 80 and over ,Observer Variation ,Incidental Findings ,Multidisciplinary ,Radiology and Imaging ,Carcinoma, Ductal, Breast ,Middle Aged ,Radiographic Image Enhancement ,Professions ,Oncology ,030220 oncology & carcinogenesis ,Benign Breast Conditions ,Female ,Radiology ,medicine.symptom ,Research Article ,Adult ,medicine.medical_specialty ,Imaging Techniques ,Neuroimaging ,Breast Neoplasms ,Malignancy ,Research and Analysis Methods ,Sensitivity and Specificity ,Calcification ,Lesion ,Diagnosis, Differential ,03 medical and health sciences ,Breast cancer ,Signs and Symptoms ,Region of interest ,Diagnostic Medicine ,Hounsfield scale ,Radiologists ,Breast Cancer ,Multidetector Computed Tomography ,Cancer Detection and Diagnosis ,Humans ,Aged ,Retrospective Studies ,business.industry ,lcsh:R ,Biology and Life Sciences ,Cancers and Neoplasms ,medicine.disease ,Fibroadenoma ,Computed Axial Tomography ,Carcinoma, Intraductal, Noninfiltrating ,People and Places ,Lesions ,Women's Health ,lcsh:Q ,Population Groupings ,Differential diagnosis ,business ,Physiological Processes ,Neuroscience - Abstract
To retrospectively determine the association between breast lesion morphology and malignancy and to determine the optimal value of lesion enhancement (HU, Hounsfield units) to improve the diagnostic accuracy of breast cancer in patients with incidental breast lesions (IBLs). A total of 97 patients with 102 IBLs detected from July 2009 to December 2012 were enrolled in this study. Two radiologists analyzed CT images for the presence of malignancy based on the morphology of the lesions alone and in combination with an enhancement value (HU) analysis. There were 36 malignant and 66 benign IBLs. When the morphology and enhancement values were combined, the sensitivity, specificity, and accuracy were 92%, 97%, and 95%, respectively, for reader 1 and 89%, 94%, and 92%, respectively, for reader 2. The addition of HU values led to correct changes in the diagnosis; specifically, the accuracy of the diagnosis of reader 1 and reader 2 improved by 6.9% and 11.8%, respectively. The addition of the enhancement value (HU) to the CT morphology improved the diagnostic accuracy in the differentiation of malignant from benign IBLs by using the region of interest (ROI) to measure the HU within the most suspicious part of the lesion.
- Published
- 2016