1. Association of Donor and Recipient Telomere Length with Clinical Outcomes following Lung Transplantation
- Author
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Souheil El-Chemaly, Anna Moniodis, Andrew M. Courtwright, Edgar L. Milford, H. Mallidi, Indira Guleria, Gary M. Hunninghake, Suneet Agarwal, Isabelle G. Wood, Sabrina Fried, Philip C. Camp, Benjamin A. Raby, Julian A. Villalba, Hilary J. Goldberg, and Ivan O. Rosas
- Subjects
Graft Rejection ,Male ,medicine.medical_treatment ,Pulmonary Fibrosis ,Respiratory System ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Liver transplantation ,Gastroenterology ,White Blood Cells ,0302 clinical medicine ,Animal Cells ,Pulmonary fibrosis ,Medicine and Health Sciences ,Lymphocytes ,Respiratory System Procedures ,lcsh:Science ,Telomere Shortening ,Telomere Length ,Multidisciplinary ,Chromosome Biology ,Hazard ratio ,Immunosuppression ,Middle Aged ,Telomere ,Prognosis ,Tissue Donors ,medicine.anatomical_structure ,Telomeres ,Treatment Outcome ,Cohort ,Female ,medicine.symptom ,Cellular Types ,Anatomy ,Research Article ,Lung Transplantation ,Adult ,medicine.medical_specialty ,Chromosome Structure and Function ,Immune Cells ,Immunology ,Surgical and Invasive Medical Procedures ,Biology ,Chromosomes ,03 medical and health sciences ,Digestive System Procedures ,Young Adult ,Transplantation Immunology ,Internal medicine ,medicine ,Lung transplantation ,Humans ,Aged ,Transplantation ,Lung ,Blood Cells ,Organ dysfunction ,lcsh:R ,Biology and Life Sciences ,Cell Biology ,Organ Transplantation ,medicine.disease ,Fibrosis ,Transplant Recipients ,Surgery ,Liver Transplantation ,030228 respiratory system ,lcsh:Q ,Clinical Immunology ,Lungs ,Clinical Medicine ,Developmental Biology - Abstract
Background Patients with short telomere syndromes and pulmonary fibrosis have increased complications after lung transplant. However, the more general impact of donor and recipient telomere length in lung transplant has not been well characterized. Methods This was an observational cohort study of patients who received lung transplant at a single center between January 1st 2012 and January 31st 2015. Relative donor lymphocyte telomere length was measured and classified into long (third tertile) and short (other tertiles). Relative recipient lung telomere length was measured and classified into short (first tertile) and long (other tertiles). Outcome data included survival, need for modification of immunosuppression, liver or kidney injury, cytomegalovirus reactivation, and acute rejection. Results Recipient lung tissue telomere lengths were measured for 54 of the 79 patients (68.3%) who underwent transplant during the study period. Donor lymphocyte telomeres were measured for 45 (83.3%) of these recipients. Neither long donor telomere length (hazard ratio [HR] = 0.58, 95% confidence interval [CI], 0.12–2.85, p = 0.50) nor short recipient telomere length (HR = 1.01, 95% CI = 0.50–2.05, p = 0.96) were associated with adjusted survival following lung transplant. Recipients with short telomeres were less likely to have acute cellular rejection (23.5% vs. 58.8%, p = 0.02) but were not more likely to have other organ dysfunction. Conclusions In this small cohort, neither long donor lymphocyte telomeres nor short recipient lung tissue telomeres were associated with adjusted survival after lung transplantation. Larger studies are needed to confirm these findings.
- Published
- 2016