1. Prognostic factors of a lower CD4/CD8 ratio in long term viral suppression HIV infected children
- Author
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Guillen, Sara, Prieto, Luis, Jimenez de Ory, Santiago, Isabel Gonzalez-Tome, Maria, Rojo, Pablo, Luisa Navarro, Maria, Jose Mellado, Maria, Escosa, Luis, Sainz, Talia, Francisco, Laura, Angeles Munoz-Fernandez, Maria, Tomas Ramos, Jose, Garcia Hortelano, Milagros, Blazquez, Daniel, Epalza, Cristina, Saavedra, Jesus, Santos, Mar, Angeles Munoz, Ma, Santiago, Begona, Carrasco, Itziar, Angel Roa, Miguel, Beceiro, Jose, Penin, Maria, Martinez, Jorge, Badillo, Katie, Apilanez, Miren, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Gomez Sirvent, Jorge, Garzon, Monica, Roman, Vicente, Jose Munoz, Maria, Angulo, Raquel, Neth, Olaf, Falcon, Lola, Terol, Pedro, Luis Santos, Juan, Moreno, David, Lendinez, Francisco, Peromingo, Estrella, Montero, Maria, Grande, Ana, Jose Romero, Francisco, Perez, Carlos, Martinez, Maria, Lillo, Miguel, Losada, Begona, Herranz, Mercedes, Bustillo, Matilde, Guerrero, Carmelo, Collado, Pilar, Antonio Couceiro, Jose, Vila, Leticia, Calvino, Consuelo, Isabel Piqueras, Ana, Breton, Rafael, Oltra, Manuel, Lopez, Eva, Segarra, Inmaculada, Gavilan, Cesar, Montesinos, Elena, Dapena, Marta, Alvarez, Cristina, Jimenez, Beatriz, Gloria Andres, Ana, Marugan, Victor, Ochoa, Carlos, Alfayate, Santiago, Isabel Menasalvas, Ana, Ruiz del Prado, Yolanda, Soler-Palacin, Pere, Antoinette Frick, Maria, Mur, Antonio, Lopez, Nuria, Mendez, Maria, Mayol, Lluis, Vallmanya, Teresa, Calavia, Olga, Garcia, Lourdes, Pineda, Valenti, Rius, Neus, Duenas, Joaquin, Fortuny, Claudia, Noguera-Julian, Antoni, and CoRISpe Cohorte Nacl VIH Pediat RE
- Subjects
Male ,Multivariate analysis ,humanos ,CD4-CD8 Ratio ,adolescente ,HIV Infections ,Pathology and Laboratory Medicine ,Pediatrics ,Families ,Mathematical and Statistical Techniques ,Antiretroviral Therapy, Highly Active ,Medicine and Health Sciences ,Public and Occupational Health ,Viral suppression ,Child ,Immune Response ,Children ,Univariate analysis ,Multidisciplinary ,inmunidad ,Statistics ,Viral Load ,Prognosis ,Vaccination and Immunization ,pronóstico ,antirretrovirales ,Anti-Retroviral Agents ,Child, Preschool ,Physical Sciences ,Medicine ,Female ,carga viral ,VIH-1 ,Pediatric Infections ,Viral load ,Research Article ,Cart ,medicine.medical_specialty ,Adolescent ,Science ,Immunology ,Antiretroviral Therapy ,Research and Analysis Methods ,Microbiology ,Immune Suppression ,Immune Activation ,Immune system ,Signs and Symptoms ,Antiviral Therapy ,Diagnostic Medicine ,Internal medicine ,Virology ,medicine ,Humans ,Statistical Methods ,lactante ,business.industry ,Immunity ,Infant, Newborn ,Infant ,Biology and Life Sciences ,Age Groups ,People and Places ,Multivariate Analysis ,HIV-1 ,Population Groupings ,infecciones por VIH ,Preventive Medicine ,business ,relación CD4-CD8 ,CD8 ,Viral Transmission and Infection ,Mathematics - Abstract
CoRISpe (Cohorte Nacional de VIH pediátrica de la RED RIS)., [Background] Combination antiretroviral therapy (cART) is associated with marked immune reconstitution. Although a long term viral suppression is achievable, not all children however, attain complete immunological recovery due to persistent immune activation. We use CD4/CD8 ratio like a marker of immune reconstitution., [Methods] Perinatal HIV-infected children who underwent a first-line cART, achieved viral suppression in the first year and maintained it for more than 5 years, with no viral rebound were included. Logistic models were applied to estimate the prognostic factors, clinical characteristics at cART start, of a lower CD4/CD8 ratio at the last visit., [Results] 146 HIV-infected children were included: 77% Caucasian, 45% male and 28% CDC C. Median age at cART initiation was 2.3 years (IQR: 0.5–6.2). 42 (30%) children received mono-dual therapy previously to cART. Time of undetectable viral load was 9.5 years (IQR: 7.8, 12.5). 33% of the children not achieved CD4/CD8 ratio >1. Univariate analysis showed an association between CD4/CD8, [Conclusions] CD4/CD8 >1 was not achieved in 33% of the children. Lower CD4 nadir and previous exposure to suboptimal therapy, before initiating cART, are factors showing independently association with a worse immune recovery (CD4/CD8 < 1).
- Published
- 2019