1. γ-Tocotrienol Induces Paraptosis-Like Cell Death in Human Colon Carcinoma SW620 Cells.
- Author
-
Zhang, Jing-Shu, Li, Da-Ming, Ma, Yue, He, Ning, Gu, Qing, Wang, Feng-Shan, Jiang, Shu-Qing, Chen, Bing-Qing, and Liu, Jia-Ren
- Subjects
- *
COLON cancer treatment , *ADENOCARCINOMA , *GASTROINTESTINAL tumors treatment , *APOPTOSIS , *GENE expression , *CANCER cells , *TOCOTRIENOL , *ANTINEOPLASTIC agents - Abstract
Colorectal cancer is one of the most serious illnesses among diagnosed cancer. As a new type of anti-cancer composition from tocotrienol-rich fraction of palm oil, γ-tocotrienol is widely used in anti-cancer research. The objectives of this study were to investigate the effects of γ-tocotrienol on human colon cancer SW620 and HCT-8 cells. We showed that treatment with different concentrations of γ-tocotrienol resulted in a dose dependent inhibition of cell growth. Cell death induced by γ-tocotrienol was mediated by a paraptosis-like cell death in SW620 and HCT-8 cells. Real-time RT-PCR and western blot analyses showed that γ-tocotrienol inhibited the expression level of β-catenin, cyclin D1 and c-jun. These data suggest that a paraptosis-like cell death induced by γ-tocotrienol in SW620 cells is associated with the suppression of the Wnt signaling pathway, which offers a novel tool for treating apoptosis-resistance colon cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF