Search

The Moral Foundations Dictionary (MFD) is a useful tool for applying the conceptual framework developed in Moral Foundations Theory and quantifying the moral meanings implicated in the linguistic information people convey. However, the applicability of the MFD is limited because it is available only in English. Translated versions of the MFD are therefore needed to study morality across various cultures, including non-Western cultures. The contribution of this paper is two-fold. We developed the first Japanese version of the MFD (referred to as the J-MFD) using a semi-automated method—this serves as a reference when translating the MFD into other languages. We next tested the validity of the J-MFD by analyzing open-ended written texts about the situations that Japanese participants thought followed and violated the five moral foundations. We found that the J-MFD correctly categorized the Japanese participants’ descriptions into the corresponding moral foundations, and that the Moral Foundations Questionnaire (MFQ) scores correlated with the frequency of situations, of total words, and of J-MFD words in the participants’ descriptions for the Harm and Fairness foundations. The J-MFD can be used to study morality unique to the Japanese and also multicultural comparisons in moral behavior. [ABSTRACT FROM AUTHOR]

Background: The involvement of cholesterol crystals (CCs) in plaque progression and destabilization of atherosclerotic plaques has been recently recognized. This study aimed to evaluate the association between the intraplaque localization of CCs and plaque vulnerability. Methods: We investigated 55 acute coronary syndrome (ACS) and 80 stable angina pectoris (stable AP) lesions using optical frequency domain imaging (OFDI) prior to percutaneous coronary intervention. The distance between CCs and the luminal surface of coronary plaques was defined as CC depth. Results: Although the incidence of CCs had similar frequencies in the ACS and stable AP groups (95% vs. 89%, p = 0.25), CC depth was significantly less in patients with ACS than in those with stable AP (median [25th to 75th percentile]: 68 μm [58 to 92 μm] vs. 152 μm [115 to 218 μm]; p < 0.001). The incidences of plaque rupture, thrombus, lipid-rich plaques, and thin-cap fibroatheroma were significantly greater in patients with ACS than in those with stable AP (62% vs. 18%, p < 0.001; 67% vs. 16%, p < 0.001; 84% vs. 57%, p < 0.01; and 56% vs. 19%, p < 0.001, respectively). Conclusion: OFDI analysis revealed that CCs were found in the more superficial layers within the coronary atherosclerotic plaques in patients with ACS than in those with stable AP, suggesting that CC depth is associated with plaque vulnerability. CC depth, a novel OFDI-derived parameter, could be potentially used as an alternative means of evaluating plaque vulnerability in coronary arteries. [ABSTRACT FROM AUTHOR]