Search

Objective: To assess whether the transient stresses of foot impact with the ground are similar to those found during midstance loading and if the location of high stress correlate with the sites most commonly associated with mechanically induced osteoarthritis (OA). We compared impact stresses in subchondral bone between two subject-specific, three-dimensional, finite-element models of the equine metacarpophalangeal (MCP) joint—one with advanced OA and one healthy, and with similar published data on the stresses that occur at midstance. Methods: Two right MCP joints (third metacarpal and proximal phalanx) were scanned using micro-computed tomography (μCT). Images were segmented, and meshed using modified 10-node quadratic tetrahedral elements. Bone material properties were assigned based on the bone density. An impact velocity of 3.55 m/s was applied to each model and contact pressures and stress distribution were calculated for each. In a separate iteration, the third metacarpal was loaded statically. A sampling grid of 160 equidistant points was superimposed over selected slices, and average peak stresses were calculated for 6 anatomical regions. Within-region maximal peak and average von Mises stresses were compared between healthy and OA bones in both midstance and impact loading. Results: Average impact stresses across all regions, in both locations (palmar and dorsal) were greater in the OA model. Highest impact stresses were located in the dorsal medial condyle in the healthy (12.8 MPa) and OA (14.1MPa) models, and were lowest in the palmar medial and lateral parasagittal grooves in the healthy (5.94 MPa) and OA (7.07 MPa) models. The healthy static model had higher peak (up to 49.7% greater) and average (up to 38.6% greater) stresses in both locations and across all regions compared to the OA static model. Conclusions: Under simulated footfall a trot, loading on the dorsal aspect of the third metacarpal at impact created stresses similar to those found during midstance. The high accelerations that occur under impact loading are likely responsible for creating the high stresses, as opposed to midstance loading where the high stresses are the result of high mass loading. Although the stress magnitudes were found to be similar among the two loading conditions, the location of the high stress loading occurred in sites that are not typically associated with osteoarthritic changes. [ABSTRACT FROM AUTHOR]

Atherosclerotic disease, and the subsequent complications of thrombosis and plaque rupture, has been associated with local shear stress. In the diseased carotid artery, local variations in shear stress are induced by various geometrical features of the stenotic plaque. Greater stenosis severity, plaque eccentricity (symmetry) and plaque ulceration have been associated with increased risk of cerebrovascular events based on clinical trial studies. Using particle image velocimetry, the levels and patterns of shear stress (derived from both laminar and turbulent phases) were studied for a family of eight matched-geometry models incorporating independently varied plaque features – i.e. stenosis severity up to 70%, one of two forms of plaque eccentricity, and the presence of plaque ulceration). The level of laminar (ensemble-averaged) shear stress increased with increasing stenosis severity resulting in 2–16 Pa for free shear stress (FSS) and approximately double (4–36 Pa) for wall shear stress (WSS). Independent of stenosis severity, marked differences were found in the distribution and extent of shear stress between the concentric and eccentric plaque formations. The maximum WSS, found at the apex of the stenosis, decayed significantly steeper along the outer wall of an eccentric model compared to the concentric counterpart, with a 70% eccentric stenosis having 249% steeper decay coinciding with the large outer-wall recirculation zone. The presence of ulceration (in a 50% eccentric plaque) resulted in both elevated FSS and WSS levels that were sustained longer (∼20 ms) through the systolic phase compared to the non-ulcerated counterpart model, among other notable differences. Reynolds (turbulent) shear stress, elevated around the point of distal jet detachment, became prominent during the systolic deceleration phase and was widely distributed over the large recirculation zone in the eccentric stenoses. [ABSTRACT FROM AUTHOR]