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Your search keyword '"Ronald M, van Dam"' showing total 2 results
Start Over Author "Ronald M, van Dam" Publisher public library of science
2 results on '"Ronald M, van Dam"'

1. Evaluating the safety of two human experimental intestinal ischemia reperfusion models

Author

Wim A. Buurman, Joep Grootjans, Inca H R Hundscheid, Dirk H. S. M. Schellekens, Joep P. M. Derikx, Kaatje Lenaerts, Ronald M. Van Dam, Geerard L. Beets, Marcel den Dulk, Cornelis H. C. Dejong, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: DA Pat AIOS (9), Surgery, MUMC+: MA AIOS Heelkunde (9), MUMC+: MA Heelkunde (9), Faculteit FHML Centraal, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Surgery, and Amsterdam Reproduction & Development (AR&D)

Subjects
Male, Cardiovascular Procedures, INTERNATIONAL STUDY-GROUP, Cancer Treatment, Vascular Surgery, Gastroenterology, Vascular Medicine, 0302 clinical medicine, Postoperative Complications, Ischemia, Medicine and Health Sciences, Postoperative Period, COMPLICATIONS, OUTCOMES, Multidisciplinary, Incidence (epidemiology), Middle Aged, Tumor Resection, CANCER, Colorectal surgery, Intestines, Jejunum, Surgical Oncology, Oncology, 030220 oncology & carcinogenesis, Reperfusion Injury, Medicine, 030211 gastroenterology & hepatology, Female, medicine.symptom, Anatomy, Research Article, Clinical Oncology, medicine.medical_specialty, Science, Surgical and Invasive Medical Procedures, PANCREATIC SURGERY, Pancreaticoduodenectomy, 03 medical and health sciences, ORGAN DYSFUNCTION, Internal medicine, COLON, medicine, MANAGEMENT, Animals, Humans, Aged, Retrospective Studies, Surgical Resection, business.industry, MORTALITY, Organ dysfunction, Cancer, Postoperative complication, Biology and Life Sciences, Retrospective cohort study, Length of Stay, medicine.disease, Gastrointestinal Tract, Clinical Medicine, Complication, business, Digestive System, Colorectal Surgery
Abstract

PLOS ONE 16(6), 0253506 (2021). doi:10.1371/journal.pone.0253506, Published by PLOS, San Francisco, California, US

Published
2021
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2. Total Intermittent Pringle Maneuver during Liver Resection Can Induce Intestinal Epithelial Cell Damage and Endotoxemia

Author

Marc H.A. Bemelmans, Steven W.M. Olde Damink, Martijn Poeze, Wim A. Buurman, Ronald M. van Dam, Simon A.W.G. Dello, Kostan W. Reisinger, Maartje A. J. van den Broek, Cornelis H. C. Dejong, Toin H. van Kuppevelt, RS: NUTRIM - R2 - Gut-liver homeostasis, and Surgery

Subjects
Adult, Male, medicine.medical_specialty, Critical Care and Emergency Medicine, Time Factors, Clinical Research Design, medicine.medical_treatment, Blood Loss, Surgical, Ischemia, lcsh:Medicine, Gastroenterology and Hepatology, Fatty Acid-Binding Proteins, Postoperative Complications, Intestinal mucosa, Blood plasma, Occlusion, medicine, Hepatectomy, Humans, Intestinal Mucosa, lcsh:Science, Aged, Aged, 80 and over, Multidisciplinary, Cell Death, business.industry, Liver Diseases, lcsh:R, Epithelial Cells, Hepatoduodenal ligament, Middle Aged, medicine.disease, Constriction, Endotoxemia, Surgery, Intestinal Diseases, Tissue engineering and pathology Translational research [NCMLS 3], medicine.anatomical_structure, Liver, Medicine, Arterial blood, lcsh:Q, Female, Splanchnic, business, Biomarkers, Research Article
Abstract

Contains fulltext : 110009.pdf (Publisher’s version ) (Open Access) OBJECTIVES: The intermittent Pringle maneuver (IPM) is frequently applied to minimize blood loss during liver transection. Clamping the hepatoduodenal ligament blocks the hepatic inflow, which leads to a non circulating (hepato)splanchnic outflow. Also, IPM blocks the mesenteric venous drainage (as well as the splenic drainage) with raising pressure in the microvascular network of the intestinal structures. It is unknown whether the IPM is harmful to the gut. The aim was to investigate intestinal epithelial cell damage reflected by circulating intestinal fatty acid binding protein levels (I-FABP) in patients undergoing liver resection with IPM. METHODS: Patients who underwent liver surgery received total IPM (total-IPM) or selective IPM (sel-IPM). A selective IPM was performed by selectively clamping the right portal pedicle. Patients without IPM served as controls (no-IPM). Arterial blood samples were taken immediately after incision, ischemia and reperfusion of the liver, transection, 8 hours after start of surgery and on the first post-operative day. RESULTS: 24 patients (13 males) were included. 7 patients received cycles of 15 minutes and 5 patients received cycles of 30 minutes of hepatic inflow occlusion. 6 patients received cycles of 15 minutes selective hepatic occlusion and 6 patients underwent surgery without inflow occlusion. Application of total-IPM resulted in a significant increase in I-FABP 8 hours after start of surgery compared to baseline (p

Published
2012

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