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Your search keyword '"Simonis, Marieke"' showing total 7 results
Start Over Author "Simonis, Marieke" Publisher public library of science
7 results on '"Simonis, Marieke"'

2. The genomic scrapheap challenge; extracting relevant data from unmapped whole genome sequencing reads, including strain specific genomic segments, in rats

Author

Hubrecht Institute with UMC, CMM, Circulatory Health, Cancer, Child Health, Brain, CMM Groep Cuppen, Van Der Weide, Robin H., Simonis, Marieke, Hermsen, Roel, Toonen, Pim, Cuppen, Edwin, de Ligt, Joep, Hubrecht Institute with UMC, CMM, Circulatory Health, Cancer, Child Health, Brain, CMM Groep Cuppen, Van Der Weide, Robin H., Simonis, Marieke, Hermsen, Roel, Toonen, Pim, Cuppen, Edwin, and de Ligt, Joep

Published
2016

3. Lack of Major Genome Instability in Tumors of p53 Null Rats

Author

LS Pathobiologie, Tissue Repair, PB TR, Hermsen, Roel, Toonen, Pim, Kuijk, Ewart, Youssef, Sameh A, Kuiper, Raoul, van Heesch, Sebastiaan, de Bruin, Alain, Cuppen, Edwin, Simonis, Marieke, LS Pathobiologie, Tissue Repair, PB TR, Hermsen, Roel, Toonen, Pim, Kuijk, Ewart, Youssef, Sameh A, Kuiper, Raoul, van Heesch, Sebastiaan, de Bruin, Alain, Cuppen, Edwin, and Simonis, Marieke

Published
2015

4. Lack of Major Genome Instability in Tumors of p53 Null Rats

Author

Hermsen, Roel, Toonen, Pim, Kuijk, Ewart, Youssef, Sameh A., Kuiper, Raoul, van Heesch, Sebastiaan, de Bruin, Alain, Cuppen, Edwin, Simonis, Marieke, Hermsen, Roel, Toonen, Pim, Kuijk, Ewart, Youssef, Sameh A., Kuiper, Raoul, van Heesch, Sebastiaan, de Bruin, Alain, Cuppen, Edwin, and Simonis, Marieke

Published
2015

5. Lack of Major Genome Instability in Tumors of p53 Null Rats

Author

CMM Groep Cuppen, CMM Sectie Genomics and Bioinformatics, Cancer, Hubrecht Institute with UMC, Child Health, Hermsen, Roel, Toonen, Pim, Kuijk, Ewart, Youssef, Sameh A., Kuiper, Raoul, van Heesch, Sebastiaan, de Bruin, Alain, Cuppen, Edwin, Simonis, Marieke, CMM Groep Cuppen, CMM Sectie Genomics and Bioinformatics, Cancer, Hubrecht Institute with UMC, Child Health, Hermsen, Roel, Toonen, Pim, Kuijk, Ewart, Youssef, Sameh A., Kuiper, Raoul, van Heesch, Sebastiaan, de Bruin, Alain, Cuppen, Edwin, and Simonis, Marieke

Published
2015

7. Maintenance of Long-Range DNA Interactions after Inhibition of Ongoing RNA Polymerase II Transcription.

Author

Palstra, Robert-Jan, Simonis, Marieke, Klous, Petra, Brasset, Emilie, Eijkelkamp, Bart, and de Laat, Wouter

Subjects
*RNA polymerases, *CELL nuclei, *CHROMOSOMES, *MITOCHONDRIAL DNA, *TRANSFERASES, *LOCUS (Genetics), *ANUCLEATE cells, *ORGANELLES, *GLUCAN synthase
Abstract

A relationship exists between nuclear architecture and gene activity and it has been proposed that the activity of ongoing RNA polymerase II transcription determines genome organization in the mammalian cell nucleus. Recently developed 3C and 4C technology allowed us to test the importance of transcription for nuclear architecture. We demonstrate that upon transcription inhibition binding of RNA polymerase II to gene regulatory elements is severely reduced. However, contacts between regulatory DNA elements and genes in the β-globin locus are unaffected and the locus still interacts with the same genomic regions elsewhere on the chromosome. This is a general phenomenon since the great majority of intra- and interchromosomal interactions with the ubiquitously expressed Rad23a gene are also not affected. Our data demonstrate that without transcription the organization and modification of nucleosomes at active loci and the local binding of specific trans-acting factors is unaltered. We propose that these parameters, more than transcription or RNA polymerase II binding, determine the maintenance of long-range DNA interactions. [ABSTRACT FROM AUTHOR]

Published
2008
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