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As the world's largest electricity-consuming country, China faces the challenge of energy conservation and environmental pollution. Therefore, it is imperative that China takes decisive action to address these issues. Based on the panel data of 30 provinces (cities, districts) in China from 2011 to 2020, we use the entropy method to measure the air pollution index in different provinces, construct two fixed effects models, panel quantile model, and spatial Durbin model to empirically analyze the impact of electricity consumption on air pollution in China's provincial regions. The experimental results show that: (1) Electricity consumption has a significant positive impact on the provincial air pollution index in China and the higher the index is, the more serious the air pollution is. When the electricity consumption increases 1%, the air pollution index will increase of by 0.0649% as accompanied. (2) Through comparison of different times, we found that the degree of increase in air pollution index caused by electricity consumption would be reduced due to the improvement of environmental protection efforts. From the perspective of different geographical locations, the electricity consumption in the southeast side of the "Hu Line" has exacerbated the impact on air pollution index. (3) According to the panel quantile regression results, the marginal effect of electricity consumption on air pollution is positive. With the increase of quantiles, the impact of electricity consumption on air pollution is increasing. (4) Spatial effect analysis shows that electricity consumption has a significant positive spatial spillover effect on air pollution index. The increase in electricity consumption not only increases the air pollution index in the local region, but also leads to an increase in the air pollution index in surrounding areas. These findings contribute to the governance of air pollution and the promotion of sustainable economic, environmental and energy development. [ABSTRACT FROM AUTHOR]

Improving green innovation efficiency (GIE) is the key to achieve high-quality economic development in China, and the introduction of foreign direct investment (FDI) has become an important path choice to promote the GIE. Based on the data of 30 provinces in China, this paper explores the linear and nonlinear effects of FDI on GIE from both quantity and quality perspectives, and further analyzes the mediating role of environmental regulation level. The results show that: (1) From 2011 to 2020, the GIE of all provinces in China generally shows an upward trend. (2) The quantity and quality of FDI have a significant positive impact on the improvement of GIE in China's provinces, and this impact has regional heterogeneity. (3) The quantity and quality of FDI can promote the improvement of GIE in China through the level of environmental regulation (ER). (4) With the level of knowledge accumulation and GIE as the threshold variables, the quantity and quality of FDI have a single threshold effect on the GIE of China's provinces. The conclusions of this study provide some policy implications for local governments to make full use of FDI to perform green innovation activities. [ABSTRACT FROM AUTHOR]

Environmental pollution has become a pressing global issue, severely threatening human health and ecosystems. As an emerging driver of economic development in countries worldwide, the digital economy (DE) has the potential to enhance resource utilization efficiency and promote the development of clean technologies, thereby reducing environmental pollution. Based on the panel data of 267 cities in China from 2012 to 2021, the spatial econometric model is used to test the impact of DE on environmental pollution. The mediating effect model is used to explore the transmission mechanism of DE affecting environmental pollution. The panel threshold model is used to examine the threshold effect of marketization. The results are as follows: (1) DE can significantly reduce environmental pollution. The conclusion is still valid after conducting robustness tests such as selecting historical data as instrumental variables and the "Broadband China" pilot as a quasi-natural experiment. (2) From the perspective of transmission mechanism, DE can reduce environmental pollution through green technology innovation and industrial structure upgrading. (3) From the perspective of spatial spillover effect, DE can reduce the environmental pollution level of surrounding cities. (4) From the perspective of threshold effect, DE has obvious market-oriented single threshold effect on environmental pollution. When the marketization level crosses the threshold of 11.6611, the emission reduction effect of DE is significant. (5) From the perspective of heterogeneity, DE has a heterogeneous impact on environmental pollution in cities with different geographic locations, resource endowments and administrative level. Regarding geographical heterogeneity, DE can effectively reduce environmental pollution in eastern and central regions, but has no significant impact on environmental pollution in western regions. Regarding the heterogeneity of resource endowment, compared to non-resource-based cities, resource-based cities suffer more from the negative effects of DE on their environment. Regarding the heterogeneity of administrative levels, compared with non-central cities, the DE of central cities has a greater emission reduction effect. Based on empirical results, this paper proposes strategic recommendations in areas such as enhancing the application of DE in emission reduction, upgrading industrial structures, promoting green technology innovation, and improving the level of marketization. This study not only enriches the research of DE and environmental pollution, but also provides a reference for the formulation of environmental pollution control policies. [ABSTRACT FROM AUTHOR]

The emissions trading system, a crucial and fundamental system reform in the environmental resources field of China, was established to promote the continuous and effective reduction of total emissions of major pollutants. In this context, based on the panel data of 285 Chinese cities (except Tibet) from 2004 to 2018, this paper uses the quasi-experimental method of Difference in Difference to assess the effect of the emissions trading system introduced on sulfur dioxide emissions of China and the transmission mechanism. The article generates several intriguing findings. (1) The emissions trading system has a significant suppressive effect on sulfur dioxide emissions. (2) Mechanistic tests show that the emissions trading system can effectively suppress sulfur dioxide emissions by reducing government intervention, stimulating green patent innovation, and improving resource use efficiency, in which green utility patents have a masking effect. (3) From the east, central and west divisions, the emissions trading system has a significant suppression effect on sulfur dioxide emission in the eastern and central regions, and the eastern region is better than the central region. (4) In terms of factor endowment, the emissions trading system has a significant suppression effect on sulfur dioxide emissions in both resource-based and non-resource-based cities, with non-resource-based cities outperforming resource-based cities; while within resource-based effect exists only in regenerative cities. (5) The emissions trading system has a significant suppression effect on sulfur dioxide emissions in old and non-old industrial base cities in industrial base zoning. The suppression effect in non-old industrial base cities is better than that in old industrial base cities. This paper provides empirical evidence for evaluating the emissions trading system at the provincial level in China and suggests policy recommendations for selecting government tools to effectively curb sulfur dioxide emissions. Although the emissions trading system has made an outstanding contribution to sulfur dioxide emissions reduction, there is still much space for further development of potential emission reductions. [ABSTRACT FROM AUTHOR]

Industrial transformation (IT) is the inevitable course for the sustainable development of resource-based cities, while digital inclusive finance (DIF) provides essential capital elements for industrial transformation. Based on the panel data of 115 resource-based cities in China from 2011 to 2019, this paper discusses the influence mechanism of digital inclusive finance on industrial transformation from the perspectives of the optimization of industrial structure (OIS) and the rationalization of industrial structure (RIS). The empirical results show that digital inclusive finance has a positive effect on both the optimization of industrial structure and the rationalization of industrial structure. Digital inclusive finance influences industrial transformation through residents' income and technological innovation. In addition, in the analysis of income gap and innovation gap, low-income regions have a better effect on the industrial transformation of industrial structure optimization, while high-income regions have a better effect in manufacturing upgrading, thus resulting in a more significant effect of industrial transformation on the rationalization of industrial structure. Obviously, the development of high-innovation regions has relative advantages with more channels for industrial transformation, which have significant effect of industrial transformation. Therefore, it is necessary to provide differentiated reform on the basis of unified development reform. [ABSTRACT FROM AUTHOR]

As China's strategic support belt, the green development of industry in the Yangtze River Economic Zone is of great significance to promote the construction of China's ecological civilization, build a modern industrial system and accelerate high-quality economic development. The study of green total factor productivity of industry in the Yangtze River Economic Zone has important theoretical and practical value for exploring the green development path of China's industry. This Paper takes the Yangtze River Economic Zone, a key strategic region in China, as the research object, selects the input and output data of industrial production from 2006 to 2018, based on DEA model. To construct an MML index considering expected and unexpected output, and to quantitatively analyze the changes of industrial GTFP in the Yangtze River Economic Zone. The results show that: (1) During the sample period, the industrial green total factor productivity in the Yangtze River Economic Zone shows the spatial characteristics of differential growth and the temporal characteristics of volatile growth. It shows the fluctuation characteristics of "N" shape. (2) According to the order of "upper, middle, and lower" reaches, the spatial pattern of industrial green total factor productivity is characterized by "lower ladder". But the difference between the upper and middle reaches is small. (3) Cities with higher green total factor productivity and lower green total factor productivity each form the characteristics of "club convergence" of spatial agglomeration. (4) Technological efficiency and technological progress efficiency have heterogeneous effects on different river basins in the upper, middle, and lower reaches, and technological progress efficiency is conducive to promoting the evolution of green total factor productivity to a high level. According to the above empirical results, this paper finally puts forward the policy recommendations to improve the industrial green total factor productivity of the Yangtze River Economic Zone and the policy recommendations to reduce the industrial differences between the Yangtze River Economic Zone. [ABSTRACT FROM AUTHOR]

The pig industry occupies an extremely significant position in agriculture. The input cost, output income and the amount of pollution emitted by pig farming of different scales are unequal. It is of great practical importance to reduce pollutant emission by improving efficiency for the development of hog breeding industry in China. With the addition of undesirable output, this paper uses the Slack Based Measure- Metafrontier Malmquist Luenberger index model considering scale heterogeneity to explore the evolution characteristics of China's green total factor productivity of pig breeding (GTPB) based on the data of China's 17 major pig producing provinces from 2004 to 2018. The results indicate that: (1) From 2004 to 2018, China's large-scale GTPB is the highest, the medium-sized is the second, and the small-scale is the lowest. (2) In terms of regional distribution, China's GTPB in western region is the highest, in eastern region is the second, and in central region is the lowest. (3) China's GTPB shows efficiency growth and technological decline from 2004 to 2018. The pig breeding industry is generally fragile, which is greatly affected by emergencies. (4)The TGR of large-scale pig breeding is closest to 1, followed by middle-scale, and finally small-scale. According to the above empirical results, this text puts forward some policy suggestions to improve GTPB and environmental protection recommendations of hog breeding. [ABSTRACT FROM AUTHOR]

As a responsible country, China should take on heavy responsibility of energy conservation and emission reduction, and it is an inevitable choice for China to develop high-tech industries and improve the innovation efficiency of high-tech industries in order to alleviate the current environmental pressure. Therefore, this paper takes the panel data of 30 provinces in China from 2005 to 2016 as the research sample, on the basis of using DEA Global-Malmquist index to measure the innovation efficiency of high-tech industries, it constructs three spatial weight matrices, by including spatial geography, spatial economic geography nesting and innovation, and then it uses Spatial Durbin Model to empirically analyze the effect of innovation efficiency of high-tech industry on CO2 emissions in China from spatial perspective. The results indicate: firstly, in China, CO2 emissions gradually increase from 2006 to 2012, however, some provinces have declined after 2012. And CO2 emissions present a descending trend from eastern coastal area to central and western region. Secondly, affected by "warning effect", CO2 emissions show a significant negative spatial spillover effect. Thirdly, the overall level of innovation efficiency of high-tech industries in China is not high, and its impact on CO2 emissions is not a simple linear relationship, but shows an "inverted N–shaped" curvilinear relation, and its decomposition index EC and TC also have similar characteristics. Obviously, the research in this paper provides a necessary theoretical support for China and some emerging developing countries to rational formulating and effective implementing the energy conservation and emission reduction policies. [ABSTRACT FROM AUTHOR]

Industrial pollution reduction is a crucial issue in the pursuit of sustainable economic and environmental development. As a product of the deep integration of traditional finance and Internet information technology, digital finance has become an effective tool for regulating the use of funds and strengthening the effectiveness of policies in the context of the digital era, which has obvious effects on industrial pollution emissions. Using panel data of 260 prefecture-level cities in China from 2011–2019 and the digital inclusive finance index jointly compiled by Peking University and Ant Financial Services Group, this paper empirically analyzes the impact of digital finance on industrial pollution emissions through fixed effects model, mediating effects model and threshold effects model. The empirical results show that digital finance can effectively reduce industrial pollution and part of the impact is achieved through industrial structure. In the process of reducing industrial pollution by digital finance, there exists double threshold effects. When the development of digital finance breaks the threshold value, the industrial pollution emission reduction effect appears to accelerate. Finally, this paper puts forward targeted suggestions to promote industrial pollution reduction and environmental economic development. [ABSTRACT FROM AUTHOR]

China's agricultural economy is developing rapidly, but the unbalanced regional development is still a key issue that needs to be discussed today. By studying the total factor productivity of green agriculture and its factors, this paper analyzes the regional differences in time and space changes between the eastern, central and western parts of China. In this paper, the total factor productivity of green agriculture is calculated and decomposed by Metafrontier Malmquist-Luenberger index based on directional distance function. The results are as follows: First, the total factor productivity level of green agriculture in China is increasing year by year, but the overall level is still at a low level and has greater volatility; Second, although the total factor productivity of green agriculture shows an upward trend, the three regions show a downward trend in turn, which has great differences; Third, there are obvious differences in technological efficiency, optimal production potential and technological gap between the eastern, central and western regions, and there are great differences in productivity among regions and provinces. Based on the results, this paper puts forward policy recommendations, according to the regional heterogeneity, from a number of angles to rely on the joint efforts of many parties to improve the level of total factor productivity of green agriculture. [ABSTRACT FROM AUTHOR]

Eggs contain the essential cholesterol and protein for the human body, which plays an irreplaceable role in human survival, production and life. There are significant differences in the development of laying hens feeding in different regions. It is of great significance to improve egg production and reduce pollution emission for China's laying hens industry. Based on the SBM model, this paper constructs MML index, considering unexpected output under common frontier, to comprehensively evaluate the green total factor productivity on Chinese laying hens (GTCL). The results show that: (1) GTCL shows a large spatial and temporal differentiation under both the common frontier and the regional frontier. Compared with the eastern region and central region, the western region has obvious advantages in GTCL. (2) GTCL overall shows a downward trend, however, it emerges an upward trend in recent years. (3) Compared with small-scale and large-scale, middle-scale GTCL has advantages. According to the above empirical results, combined with the China's actual national situation, this paper finally puts forward some policy recommendations to improve GTCL. [ABSTRACT FROM AUTHOR]

Grain production is vital to the national economy and people's livelihood, and improving grain production efficiency is of great significance to the sustainable development of China's economy and society. From the perspective of financial support, using the DEA global Malmquist productivity index model and based on the data of 13 main grain producing areas in China from 2001 to 2017, this paper discusses the evolution characteristics and regional distribution differences of the total factor productivity index of grain production in China's main grain producing areas. The results show that from 2001 to 2017, the total factor productivity index of grain production in China's main grain producing areas showed an overall fluctuation trend of gradual decline, with an average annual decline of 7.3%. From the perspective of spatial analysis, the grain production efficiency in China's main grain producing areas is characterized by uneven spatial development, which is generally manifested as the decreasing trend from the central region to the eastern and western regions. Meanwhile, it can be seen from the decomposition index that the change of total factor productivity of grain production in China's main grain producing areas mainly depends on the change of technical efficiency. [ABSTRACT FROM AUTHOR]

In many cancers, microRNA-193a (miR-193a) is a suppressor miRNA, but its underlying anti-oncogenic activity in breast cancer is not known. In this study, we found decreased miR-193a (specifically, miR-193a-5p) expression not only in breast cancer cell lines but also in breast cancer tissues as compared with the adjacent non-tumor tissues. Ectopic miR-193a overexpression inhibited the proliferation, colony formation, migration, and invasion of MDA-MB-231 and BT549 cells. miR-193a reduced Wilms’ tumor 1 (WT1) expression and repressed luciferase reporter activity by binding WT1 coding region sequences; mutation of the predicted miR-193a binding site abolished this effect. miR-193a and WT1 expression were significantly inversely correlated in breast cancer tissues. Importantly, the anti-cancer activity induced by miR-193a was partially reversed by WT1 overexpression, indicating an important role for WT1 in such activity related to miR-193a. Our results reveal that miR-193a-WT1 interaction plays an important role in breast cancer metastasis, and suggest that restoring miR-193a expression is a therapeutic strategy in breast cancer. [ABSTRACT FROM AUTHOR]

Background: Hepatitis B virus-related liver fibrosis (HBV-LF) always progresses from inflammation to fibrosis. However, the relationship between these two pathological conditions is not fully understood. Here, it is postulated that the balance between regulatory T (Treg) cells and T helper 17 (Th17) cells as an indicator of inflammation may predict fibrosis progression of HBV-LF. Methodology/Principal Findings: The frequencies and phenotypes of peripheral Treg and Th17 cells of seventy-seven HBeAg-positive chronic hepatitis B (CHB) patients who underwent liver biopsies and thirty healthy controls were determined by flow cytometry. In the periphery of CHB patients, both Treg and Th17 frequencies were significantly increased and correlated, and a lower Treg/Th17 ratio always indicated more liver injury and fibrosis progression. To investigate exact effects of Treg and Th17 cells during HBV-LF, a series of in vitro experiments were performed using purified CD4+, CD4+CD25+, or CD4+CD252 cells from the periphery, primary human hepatic stellate cells (HSCs) isolated from healthy liver specimens, human recombinant interleukin (IL)-17 cytokine, anti-IL-17 antibody and HBcAg. In response to HBcAg, CD4+CD25+ cells significantly inhibited cell proliferation and cytokine production (especially IL-17 and IL-22) by CD4+CD252 cells in cell-contact and dose-dependent manners. In addition, CD4+ cells from CHB patients, compared to those from HC subjects, dramatically promoted proliferation and activation of human HSCs. Moreover, in a dramatically dose-dependent manner, CD4+CD25+ cells from CHB patients inhibited, whereas recombinant IL-17 response promoted the proliferation and activation of HSCs. Finally, in vivo evidence about effects of Treg/Th17 balance during liver fibrosis was obtained in concanavalin A-induced mouse fibrosis models via depletion of CD25+ or IL-17+ cells, and it's observed that CD25 depletion promoted, whereas IL-17 depletion, alleviated liver injury and fibrosis progression. Conclusions/Significance: The Treg/Th17 balance might influence fibrosis progression in HBV-LF via increase of liver injury and promotion of HSCs activation. [ABSTRACT FROM AUTHOR]

As a responsible country, China should take on heavy responsibility of energy conservation and emission reduction, and it is an inevitable choice for China to develop high-tech industries and improve the innovation efficiency of high-tech industries in order to alleviate the current environmental pressure. Therefore, this paper takes the panel data of 30 provinces in China from 2005 to 2016 as the research sample, on the basis of using DEA Global-Malmquist index to measure the innovation efficiency of high-tech industries, it constructs three spatial weight matrices, by including spatial geography, spatial economic geography nesting and innovation, and then it uses Spatial Durbin Model to empirically analyze the effect of innovation efficiency of high-tech industry on CO2 emissions in China from spatial perspective. The results indicate: firstly, in China, CO2 emissions gradually increase from 2006 to 2012, however, some provinces have declined after 2012. And CO2 emissions present a descending trend from eastern coastal area to central and western region. Secondly, affected by "warning effect", CO2 emissions show a significant negative spatial spillover effect. Thirdly, the overall level of innovation efficiency of high-tech industries in China is not high, and its impact on CO2 emissions is not a simple linear relationship, but shows an "inverted N-shaped" curvilinear relation, and its decomposition index EC and TC also have similar characteristics. Obviously, the research in this paper provides a necessary theoretical support for China and some emerging developing countries to rational formulating and effective implementing the energy conservation and emission reduction policies., Competing Interests: The authors have declared that no competing interests exist.