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1. Plasma elaidic acid level as biomarker of industrial trans fatty acids and risk of weight change: report from the EPIC study.

Author

Véronique Chajès, Carine Biessy, Pietro Ferrari, Isabelle Romieu, Heinz Freisling, Inge Huybrechts, Augustin Scalbert, Bas Bueno de Mesquita, Dora Romaguera, Marc J Gunter, Paolo Vineis, Camilla Plambeck Hansen, Marianne Uhre Jakobsen, Françoise Clavel-Chapelon, Guy Fagherazzi, Marie-Christine Boutron-Ruault, Verana Katzke, Jasmine Neamat-Allah, Heiner Boeing, Ursula Bachlechner, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Valeria Pala, Giovanna Masala, Amalia Mattiello, Guri Skeie, Elisabete Weiderpass, Antonio Agudo, Jose Maria Huerta, Eva Ardanaz, Maria Jose Sánchez, Miren Dorronsoro, Jose Ramon Quirós, Ingegerd Johansson, Anna Winkvist, Emily Sonested, Tim Key, Kay-Tee Khaw, Nicolas J Wareham, Petra H M Peeters, and Nadia Slimani

Subjects
Medicine, Science
Abstract

BACKGROUND:Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS:Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow-up, age, energy, alcohol, smoking status, physical activity, and region. RESULTS:In women, doubling elaidic acid was associated with a decreased risk of weight loss (odds ratio (OR) = 0.69, 95% confidence interval (CI) = 0.55-0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5-year follow-up (OR = 1.23, 95% CI = 0.97-1.56, p = 0.082) (p-trend

Published
2015
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2. Macronutrient composition of the diet and prospective weight change in participants of the EPIC-PANACEA study.

Author

Anne-Claire Vergnaud, Teresa Norat, Traci Mouw, Dora Romaguera, Anne M May, H Bas Bueno-de-Mesquita, Daphne van der A, Antonio Agudo, Nicholas Wareham, Kay-Tee Khaw, Isabelle Romieu, Heinz Freisling, Nadia Slimani, Florence Perquier, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Domenico Palli, Franco Berrino, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, Laudina Rodríguez, Esther Molina-Montes, Pilar Amiano, Aurelio Barricarte, Maria-Dolores Chirlaque, Francesca L Crowe, Philippos Orfanos, Androniki Naska, Antonia Trichopoulou, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Brian Buijsse, Ingeged Johansson, Göran Hallmans, Isabel Drake, Emily Sonestedt, Marianne Uhre Jakobsen, Kim Overvad, Anne Tjønneland, Jytte Halkjær, Guri Skeie, Tonje Braaten, Eiliv Lund, Elio Riboli, and Petra H M Peeters

Subjects
Medicine, Science
Abstract

BACKGROUND:The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial. METHODS:373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and self-reported at follow-up in most centers. The association between weight change after 5 years of follow-up and the iso-energetic replacement of 5% of energy from one macronutrient by 5% of energy from another macronutrient was assessed using multivariate linear mixed-models. The risk of becoming overweight or obese after 5 years was investigated using multivariate Poisson regressions stratified according to initial Body Mass Index. RESULTS:A higher proportion of energy from fat at the expense of carbohydrates was not significantly associated with weight change after 5 years. However, a higher proportion of energy from protein at the expense of fat was positively associated with weight gain. A higher proportion of energy from protein at the expense of carbohydrates was also positively associated with weight gain, especially when carbohydrates were rich in fibre. The association between percentage of energy from protein and weight change was slightly stronger in overweight participants, former smokers, participants ≥60 years old, participants underreporting their energy intake and participants with a prudent dietary pattern. Compared to diets with no more than 14% of energy from protein, diets with more than 22% of energy from protein were associated with a 23-24% higher risk of becoming overweight or obese in normal weight and overweight subjects at baseline. CONCLUSION:Our results show that participants consuming an amount of protein above the protein intake recommended by the American Diabetes Association may experience a higher risk of becoming overweight or obese during adult life.

Published
2013
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3. Combined impact of lifestyle factors on prospective change in body weight and waist circumference in participants of the EPIC-PANACEA study.

Author

Anne M May, Dora Romaguera, Noémie Travier, Ulf Ekelund, Manuela M Bergmann, Rudolf Kaaks, Birgit Teucher, Annika Steffen, Heiner Boeing, Jytte Halkjaer, Anne Tjonneland, Marianne Uhre Jakobsen, Kim Overvad, Laureen Dartois, Guy Fagherazzi, Marie-Christine Boutron-Ruault, J Ramón Quirós, Antonio Agudo, Carlos Gonzalez, María-José Sánchez, Pilar Amiano, Jose-Maria Huerta, Eva Ardanaz, Nicholas J Wareham, Francesca L Crowe, Androniki Naska, Philippos Orfanos, Antonia Trichopoulou, Domenico Palli, Claudia Agnoli, Rosario Tumino, Paolo Vineis, Salvatore Panico, H Bas Bueno-de-Mesquita, Monique Verschuren, Isabel Drake, Emily Sonestedt, Tonje Braaten, Sabina Rinaldi, Isabelle Romieu, Nadia Slimani, Teresa Norat, Elio Riboli, and Petra H M Peeters

Subjects
Medicine, Science
Abstract

The evidence that individual dietary and lifestyle factors influence a person's weight and waist circumference is well established; however their combined impact is less well documented. Therefore, we investigated the combined effect of physical activity, nutrition and smoking status on prospective gain in body weight and waist circumference.We used data of the prospective EPIC-PANACEA study. Between 1992 and 2000, 325,537 participants (94,445 men and 231,092 women, aged between 25-70) were recruited from nine European countries. Participants were categorised into two groups (positive or negative health behaviours) for each of the following being physically active, adherent to a healthy (Mediterranean not including alcohol) diet, and never-smoking for a total score ranging from zero to three. Anthropometric measures were taken at baseline and were mainly self-reported after a medium follow-up time of 5 years.Mixed-effects linear regression models adjusted for age, educational level, alcohol consumption, baseline body mass index and follow-up time showed that men and women who reported to be physically active, never-smoking and adherent to the Mediterranean diet gained over a 5-year period 537 (95% CI -706, -368) and 200 (-478, -87) gram less weight and 0.95 (-1.27, -0.639) and 0.99 (-1.29, -0.69) cm less waist circumference, respectively, compared to participants with zero healthy behaviours.The combination of positive health behaviours was associated with significantly lower weight and waist circumference gain.

Published
2012
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4. Social inequalities and mortality in Europe--results from a large multi-national cohort.

Author

Valentina Gallo, Johan P Mackenbach, Majid Ezzati, Gwenn Menvielle, Anton E Kunst, Sabine Rohrmann, Rudolf Kaaks, Birgit Teucher, Heiner Boeing, Manuela M Bergmann, Anne Tjønneland, Susanne O Dalton, Kim Overvad, Maria-Luisa Redondo, Antonio Agudo, Antonio Daponte, Larraitz Arriola, Carmen Navarro, Aurelio Barricante Gurrea, Kay-Tee Khaw, Nick Wareham, Tim Key, Androniki Naska, Antonia Trichopoulou, Dimitrios Trichopoulos, Giovanna Masala, Salvatore Panico, Paolo Contiero, Rosario Tumino, H Bas Bueno-de-Mesquita, Peter D Siersema, Petra P Peeters, Sophia Zackrisson, Martin Almquist, Sture Eriksson, Göran Hallmans, Guri Skeie, Tonje Braaten, Eiliv Lund, Anne-Kathrin Illner, Traci Mouw, Elio Riboli, and Paolo Vineis

Subjects
Medicine, Science
Abstract

BACKGROUND:Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. METHODS:A total of 3,456,689 person/years follow-up of the European Prospective Investigation into Cancer and Nutrition (EPIC) was analysed. Educational level of subjects coming from 9 European countries was recorded as proxy for socio-economic status (SES). Cox proportional hazard model's with a step-wise inclusion of explanatory variables were used to explore the association between SES and mortality; a Relative Index of Inequality (RII) was calculated as measure of relative inequality. RESULTS:Total mortality among men with the highest education level is reduced by 43% compared to men with the lowest (HR 0.57, 95% C.I. 0.52-0.61); among women by 29% (HR 0.71, 95% C.I. 0.64-0.78). The risk reduction was attenuated by 7% in men and 3% in women by the introduction of smoking and to a lesser extent (2% in men and 3% in women) by introducing body mass index and additional explanatory variables (alcohol consumption, leisure physical activity, fruit and vegetable intake) (3% in men and 5% in women). Social inequalities were highly statistically significant for all causes of death examined in men. In women, social inequalities were less strong, but statistically significant for all causes of death except for cancer-related mortality and injuries. DISCUSSION:In this European study, substantial social inequalities in mortality among European men and women which cannot be fully explained away by accounting for known common risk factors for chronic diseases are reported.

Published
2012
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5. The Impact of Dietary and Metabolic Risk Factors on Cardiovascular Diseases and Type 2 Diabetes Mortality in Brazil

Author

Abla Sibai, Nurindrawaty Lipoeto, Regina Fisberg, Peter Bjerregaard, Christian Haerpfer, Anna Waskiewicz, Philippos Orfanos, Szponar Lucjan, Androniki Naska, Lennert Veerman, Eric Ding, Nahla Hwalla, Farshad Farzadfar, Neville Calleja, Carlos Monteiro, Maria Laura Louzada, Inga Thorsdottir, and Balakrishna Nagalla

Subjects
Male, Gerontology, Global Burden of Diseases, Injuries, and Risk Factors Metabolic Risk Factors of Chronic Diseases Expert Group and Nutrition and Chronic Diseases Expert Group (NutriCoDE), FATORES DE RISCO, Blood Pressure, Type 2 diabetes, Cardiovascular Medicine, 030204 cardiovascular system & hematology, Vascular Medicine, Biochemistry, Body Mass Index, Endocrinology, 0302 clinical medicine, Glucose Metabolism, Animal Products, Risk Factors, Medicine and Health Sciences, Medicine, 030212 general & internal medicine, Prospective cohort study, Aged, 80 and over, 2. Zero hunger, Multidisciplinary, 1. No poverty, Agriculture, Middle Aged, PREVALENCE, 3. Good health, Stroke, Multidisciplinary Sciences, Hemorrhagic Stroke, Cholesterol, Neurology, Cardiovascular Diseases, Carbohydrate Metabolism, Science & Technology - Other Topics, Female, HEALTH, BURDEN, Risk assessment, Brazil, Research Article, Adult, Meat, Endocrine Disorders, General Science & Technology, Cerebrovascular Diseases, Science, Risk Assessment, 03 medical and health sciences, Environmental health, Diabetes mellitus, MD Multidisciplinary, Diabetes Mellitus, Adults, Humans, Risk factor, Ischemic Stroke, Nutrition, Aged, Science & Technology, business.industry, Health Risk Analysis, Biology and Life Sciences, Feeding Behavior, medicine.disease, TRENDS, Diet, Health Care, Metabolism, Diabetes Mellitus, Type 2, Age Groups, Food, Metabolic Disorders, HOUSEHOLD FOOD AVAILABILITY, Relative risk, People and Places, Population Groupings, INJURIES, Observational study, business, Body mass index
Abstract

BackgroundTrends in food availability and metabolic risk factors in Brazil suggest a shift toward unhealthy dietary patterns and increased cardiometabolic disease risk, yet little is known about the impact of dietary and metabolic risk factors on cardiometabolic mortality in Brazil.MethodsBased on data from Global Burden of Disease (GBD) Study, we used comparative risk assessment to estimate the burden of 11 dietary and 4 metabolic risk factors on mortality due to cardiovascular diseases and diabetes in Brazil in 2010. Information on national diets and metabolic risks were obtained from the Brazilian Household Budget Survey, the Food and Agriculture Organization database, and large observational studies including Brazilian adults. Relative risks for each risk factor were obtained from meta-analyses of randomized trials or prospective cohort studies; and disease-specific mortality from the GBD 2010 database. We quantified uncertainty using probabilistic simulation analyses, incorporating uncertainty in dietary and metabolic data and relative risks by age and sex. Robustness of findings was evaluated by sensitivity to varying feasible optimal levels of each risk factor.ResultsIn 2010, high systolic blood pressure (SBP) and suboptimal diet were the largest contributors to cardiometabolic deaths in Brazil, responsible for 214,263 deaths (95% uncertainty interval [UI]: 195,073 to 233,936) and 202,949 deaths (95% UI: 194,322 to 211,747), respectively. Among individual dietary factors, low intakes of fruits and whole grains and high intakes of sodium were the largest contributors to cardiometabolic deaths. For premature cardiometabolic deaths (before age 70 years, representing 40% of cardiometabolic deaths), the leading risk factors were suboptimal diet (104,169 deaths; 95% UI: 99,964 to 108,002), high SBP (98,923 deaths; 95%UI: 92,912 to 104,609) and high body-mass index (BMI) (42,643 deaths; 95%UI: 40,161 to 45,111).Conclusionsuboptimal diet, high SBP, and high BMI are major causes of cardiometabolic death in Brazil, informing priorities for policy initiatives.

Published
2016

6. Combined Impact of Lifestyle Factors on Prospective Change in Body Weight and Waist Circumference in Participants of the EPIC-PANACEA Study

Author

Salvatore Panico, Marianne Uhre Jakobsen, Carlos González, Noémie Travier, Emily Sonestedt, Dora Romaguera, Rosario Tumino, Kim Overvad, Rudolf Kaaks, Isabel Drake, Petra H.M. Peeters, Sabina Rinaldi, Domenico Palli, María José Sánchez, Jytte Halkjær, Marie-Christine Boutron-Ruault, Antonio Agudo, Isabelle Romieu, Francesca L. Crowe, Anne M. May, Paolo Vineis, J. Ramón Quirós, Nadia Slimani, Claudia Agnoli, Eva Ardanaz, Philippos Orfanos, José María Huerta, Pilar Amiano, H. Bas Bueno-de-Mesquita, Antonia Trichopoulou, Elio Riboli, Heiner Boeing, Teresa Norat, Manuela M. Bergmann, Tonje Braaten, Monique Verschuren, Androniki Naska, Birgit Teucher, Ulf Ekelund, Guy Fagherazzi, Annika Steffen, Anne Tjønneland, Laureen Dartois, Nicholas J. Wareham, May, Am, Romaguera, D, Travier, N, Ekelund, U, Bergmann, Mm, Kaaks, R, Teucher, B, Steffen, A, Boeing, H, Halkjaer, J, Tjonneland, A, Jakobsen, Mu, Overvad, K, Dartois, L, Fagherazzi, G, Boutron Ruault, Mc, Quir?s, Jr, Agudo, A, Gonzalez, C, S?nchez, Mj, Amiano, P, Huerta, Jm, Ardanaz, E, Wareham, Nj, Crowe, Fl, Naska, A, Orfanos, P, Trichopoulou, A, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, Salvatore, Bueno de Mesquita, Hb, Verschuren, M, Drake, I, Sonestedt, E, Braaten, T, Rinaldi, S, Romieu, I, Slimani, N, Norat, T, Riboli, E, and Peeters, Ph

Subjects
Gerontology, Male, Mediterranean diet, Non-Clinical Medicine, Epidemiology, Health Behavior, lcsh:Medicine, 0302 clinical medicine, Modiried Mediterranean diet, Mass index, 030212 general & internal medicine, Prospective Studies, lcsh:Science, Cancer, 2. Zero hunger, Multidisciplinary, Nutrition and Dietetics, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, Smoking, Abdominal adiposity, Middle Aged, Circumference, Socioeconomic Aspects of Health, Europe, Multidisciplinary Sciences, Health Education and Awareness, Medicine, Science & Technology - Other Topics, Female, Public Health, medicine.symptom, Waist Circumference, Behavioral and Social Aspects of Health, Research Article, Adult, Waist, 030209 endocrinology & metabolism, Motor Activity, Alcohol-consumption, 03 medical and health sciences, Health behaviours, medicine, Humans, Obesity, Life Style, Aged, Nutrition, Randomized controlled-trail, Health Care Policy, Science & Technology, business.industry, Body Weight, lcsh:R, Health Risk Analysis, Anthropometry, Prospective cohort, medicine.disease, Diet, lcsh:Q, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, business, Weight gain, Body mass index, Demography
Abstract

Background: The evidence that individual dietary and lifestyle factors influence a person's weight and waist circumference is well established; however their combined impact is less well documented. Therefore, we investigated the combined effect of physical activity, nutrition and smoking status on prospective gain in body weight and waist circumference. Methods: We used data of the prospective EPIC-PANACEA study. Between 1992 and 2000, 325,537 participants (94,445 men and 231,092 women, aged between 25-70) were recruited from nine European countries. Participants were categorised into two groups (positive or negative health behaviours) for each of the following being physically active, adherent to a healthy (Mediterranean not including alcohol) diet, and never-smoking for a total score ranging from zero to three. Anthropometric measures were taken at baseline and were mainly self-reported after a medium follow-up time of 5 years. Results: Mixed-effects linear regression models adjusted for age, educational level, alcohol consumption, baseline body mass index and follow-up time showed that men and women who reported to be physically active, never-smoking and adherent to the Mediterranean diet gained over a 5-year period 537 (95% CI -706, -368) and 200 (-478, -87) gram less weight and 0.95 (-1.27, -0.639) and 0.99 (-1.29, -0.69) cm less waist circumference, respectively, compared to participants with zero healthy behaviours. Conclusion: The combination of positive health behaviours was associated with significantly lower weight and waist circumference gain.

Published
2012

7. Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study

Author

Petra H.M. Peeters, Kay-Tee Khaw, Guri Skeie, Ingegerd Johansson, NJ Wareham, Ursula Bachlechner, María José Sánchez, José María Huerta, Jasmine Neamat-Allah, Pietro Ferrari, Antonia Trichopoulou, Androniki Naska, Emily Sonested, Veronique Chajes, Elisabete Weiderpass, Marc J. Gunter, Carine Biessy, Anna Winkvist, Eva Ardanaz, Philippos Orfanos, Antonio Agudo, Franҫoise Clavel-Chapelon, Isabelle Romieu, Timothy J. Key, Paolo Vineis, Guy Fagherazzi, Miren Dorronsoro, Augustin Scalbert, Heinz Freisling, Nadia Slimani, Amalia Mattiello, Marianne Uhre Jakobsen, Verana Katzke, José Ramón Quirós, Valeria Pala, Dora Romaguera, Bas Bueno de Mesquita, Giovanna Masala, Heiner Boeing, Marie-Christine Boutron-Ruault, Inge Huybrechts, Camilla Plambeck Hansen, [Chajès,V, Biessy,C, Ferrari,P, Romieu,I, Freisling,H, Huybrechts,I, Scalbert,A, Sliman,N] Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France. [Bueno de Mesquita,B, Romaguera,D, Gunter,MJ, Vineis,P, Peeters,PHM] Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom. [Bueno de Mesquita,B] Department For Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. [Plambeck Hansen,C, Uhre Jakobsen,M] Department of Public Health, Section of Epidemiology, Aarhus University, Aarhus, Denmark. [Clavel-Chapelon,F, Fagherazz,G, Boutron-Ruaul,M] INSERM, Centre for research in Epidemiology and Population Health (CESP), Nutrition, Hormones and Women’s Health team, Villejuif, France. [Clavel- Chapelon,F, Boutron-Ruaul,M] University Paris Sud, UMRS 1018, Villejuif, France. [Clavel-Chapelon,F, Boutron-Ruaul,M] Institute Gustave Roussy, Villejuif, France. [Katzke,V, Neamat-Allah,J] The German Cancer Research Center (DKFZ), Heildelberg, Germany. [Boeing,H, Bachlechner,U] Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany. [Trichopoulou,A, Naska,A, Orfanos,P] Hellenic Health Foundation, Athens, Greece. [Trichopoulou,A, Orfanos,P] Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. [Pala,V] Epidemiology and Prevention Unit, IRCCS Foundation, National Cancer Institute, Milan, Italy. [Masala,G] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy. [Mattiello,A] Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. [Skeie,G, Weiderpass,E] Department of Community Medicine, University of Tromsø-The Arctic University of Norway, Norway. [Romaguera,D] Instituto de Investigacion Sanitaria de Palma (IdISPa) and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain. [Agudo,A] Unit of Nutrition, Environment, and Cancer, Catalan Institute of Oncology-ICO, IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain. [Huerta,JM] Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. [Huerta,JM, Ardanaz,E, Sánchez,MJ] CIBER Epidemiology and Public Health CIBERESP, Spain. [Ardanaz,E] Navarre Public Health Institute, Pamplona, Spain. [Sánchez,MJ Andalusian School of Public Health, Granada, Spain. [Dorronsoro,M] Public health Direction and Biodonostia- CIBERESP, Basque Regional Health Department, San Sebastian, Spain. [Quirós,JR] Public Health Directorate, Asturias, Spain. [Johansson,I] Department of odontology, Umeå University, Sweden. [Winkvis,A] Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Sweden. [Sonested,E] Department of Clinical Sciences in Malmö, Nutrition Epidemiology, Lund University, Malmö, Sweden. [Key,T] The Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom. [Khaw,K] Clinical Gerontology Unit, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom. [Wareham,NJ] MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom. [Peeters,PHM] Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands., Funding: The EPIC- PANACEA ((European Prospective Investigation into Cancer-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating out of home And obesity) project received funding from the Public Health Programme of the European Union (2005328). EPIC was financially supported by the European Commission: Public Health and Consumer Protection Directorate 1993–2004, and Research Directorate-General 2005. Ligue contre le Cancer, Société 3M, Mutuelle

Subjects
Male, riesgo, ácidos grasos trans, humanos, RATIONALE, lcsh:Medicine, Àcids grassos, Oleic Acids, Ácidos Oléicos, estudios de seguimiento, Biochemistry, chemistry.chemical_compound, Biomarkers, Fatty acids, Isomers, Phospholipids, Weight gain, Fats, Alcohol consumption, Weight loss, Surveys and Questionnaires, estudios prospectivos, Medicine and Health Sciences, PARTICIPANTS, Public Health Surveillance, Prospective Studies, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional Status [Medical Subject Headings], Food science, lcsh:Science, Estado Nutricional, Prospective cohort study, Ácidos grasos, ASSOCIATIONS, Medicine(all), 2. Zero hunger, Nutrition and Dietetics, Multidisciplinary, Agricultural and Biological Sciences(all), NUTRITION TRANSITION, Marcadores biológicos, Biochemical markers, Chemicals and Drugs::Lipids::Fatty Acids [Medical Subject Headings], Trans Fatty Acids, Diseases::Neoplasms [Medical Subject Headings], CANCER, Elaidic acid, Neoplasias, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Multidisciplinary Sciences, Europe, Näringslära, ácido oleico, ADIPOSE-TISSUE, BODY-WEIGHT, Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Fatty Acids, Monounsaturated::Oleic Acids [Medical Subject Headings], Marcadors bioquímics, Science & Technology - Other Topics, Obesitat, Biomarker (medicine), Female, Dieta, medicine.symptom, Research Article, Risk, General Science & Technology, ácidos oleicos, PROCESSED FOODS, Endocrinology and Diabetes, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings], DIET, MD Multidisciplinary, Chemicals and Drugs::Biological Factors::Biological Markers [Medical Subject Headings], medicine, Humans, VDP::Medisinske Fag: 700, vigilancia en salud pública, Obesity, obesidad, Science & Technology, Biochemistry, Genetics and Molecular Biology(all), business.industry, lcsh:R, Body Weight, peso corporal, Weight change, Peso corporal, VDP::Medical disciplines: 700, Oleic acid, chemistry, Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight [Medical Subject Headings], lcsh:Q, business, Genetics and Molecular Biology(all), Follow-Up Studies, Oleic Acid, Estudios epidemiológicos, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies [Medical Subject Headings]
Abstract

Background Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. Methods Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region. Results In women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend, The EPIC-PANACEA ((European Prospective Investigation into Cancer-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating out of home And obesity) project received funding from the Public Health Programme of the European Union (2005328). EPIC was financially supported by the European Commission: Public Health and Consumer Protection Directorate 1993-2004; Research Directorate-General 2005. Ligue contre le Cancer, Societe 3M, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France); German Cancer Aid, German Cancer Research Center, Federal Ministry of Education and Research (Germany); Danish Cancer Society (Denmark); Health Research Institute Carlos III (RTICC Rd06/0020/0091 and Rd12/0036/0018) from the Spanish Ministry of Health, the participating regional governments and institutions (Spain); Cancer Research UK, Medical Research Council, Stroke Association, British Heart Foundation, Department of Health, Food Standards Agency, the Wellcome Trust (United Kingdom); Hellenic Health Foundation (Greece); Italian Association for Research on Cancer, National Research Council, Associazione Italiana per la Ricerca sul Cancro-AIRC (Italy); Dutch Ministry of Public Health, Welfare and Sports, Dutch Ministry of Health, Dutch Prevention Funds, LK Research Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) (The Netherlands); Swedish Cancer Society, Swedish Scientific Council, Regional Government of Skane (Sweden); Norwegian Cancer Society (Norway). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Published
2015

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