1. PKCθ regulates T cell motility via ezrin-radixin-moesin localization to the uropod.
- Author
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Judy L Cannon, Francois Asperti-Boursin, Kenneth A Letendre, Ivy K Brown, Katy E Korzekwa, Kelly M Blaine, Sreenivasa R Oruganti, Anne I Sperling, and Melanie E Moses
- Subjects
Medicine ,Science - Abstract
Cell motility is a fundamental process crucial for function in many cell types, including T cells. T cell motility is critical for T cell-mediated immune responses, including initiation, activation, and effector function. While many extracellular receptors and cytoskeletal regulators have been shown to control T cell migration, relatively few signaling mediators have been identified that can modulate T cell motility. In this study, we find a previously unknown role for PKCθ in regulating T cell migration to lymph nodes. PKCθ localizes to the migrating T cell uropod and regulates localization of the MTOC, CD43 and ERM proteins to the uropod. Furthermore, PKCθ-deficient T cells are less responsive to chemokine induced migration and are defective in migration to lymph nodes. Our results reveal a novel role for PKCθ in regulating T cell migration and demonstrate that PKCθ signals downstream of CCR7 to regulate protein localization and uropod formation.
- Published
- 2013
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