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2 results on '"Beate Betz"'

1. Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin.

Author

Maura Carrai, Verena Steinke, Pavel Vodicka, Barbara Pardini, Nils Rahner, Elke Holinski-Feder, Monika Morak, Hans K Schackert, Heike Görgens, Susanne Stemmler, Beate Betz, Matthias Kloor, Christoph Engel, Reinhard Büttner, Alessio Naccarati, Ludmila Vodickova, Jan Novotny, Angelika Stein, Kari Hemminki, Peter Propping, Asta Försti, Federico Canzian, Roberto Barale, and Daniele Campa

Subjects
Medicine, Science
Abstract

Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (OR = 1.28, 95% CI 0.99-1.67; P(value) = 0.058) and statistically significant in the German population (OR = 1.36, 95% CI 1.06-1.75; P(value) = 0.016) and in the joint analysis (OR = 1.34, 95% CI 1.12-1.61; P(value) = 0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin.

Published
2011
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2. Association Between TAS2R38 Gene Polymorphisms and Colorectal Cancer Risk: A Case-Control Study in Two Independent Populations of Caucasian Origin

Author

Matthias Kloor, Nils Rahner, Beate Betz, Reinhard Büttner, Verena Steinke, Pavel Vodicka, Christoph Engel, Barbara Pardini, Monika Morak, Jan Novotny, Federico Canzian, Daniele Campa, Angelika Stein, Hans K. Schackert, Maura Carrai, Elke Holinski-Feder, Ludmila Vodickova, Heike Görgens, Roberto Barale, Kari Hemminki, Alessio Naccarati, Asta Försti, Peter Propping, and Susanne Stemmler

Subjects
Oncology, Male, Heredity, Colorectal cancer, Epidemiology, Genome-wide association study, Receptors, G-Protein-Coupled, Gastrointestinal Cancers, Clinical Epidemiology, Genetics, education.field_of_study, Molecular Epidemiology, Multidisciplinary, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, Phenotypes, TAS2R38, Phenotype, Genetic Epidemiology, Medicine, Female, Colorectal Neoplasms, Cancer Epidemiology, Research Article, Adult, Quality Control, medicine.medical_specialty, Science, Population, Genotypes, Single-nucleotide polymorphism, Gastroenterology and Hepatology, Biology, Polymorphism, Single Nucleotide, White People, Internal medicine, Genetic variation, medicine, Cancer Genetics, Humans, Genetic Predisposition to Disease, education, Genetic Association Studies, Aged, Haplotype, Case-control study, Human Genetics, medicine.disease, Haplotypes, Case-Control Studies, Genetic Polymorphism, Population Genetics
Abstract

Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (OR = 1.28, 95% CI 0.99-1.67; P(value) = 0.058) and statistically significant in the German population (OR = 1.36, 95% CI 1.06-1.75; P(value) = 0.016) and in the joint analysis (OR = 1.34, 95% CI 1.12-1.61; P(value) = 0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin.

Published
2011

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