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4 results on '"Eirik Ikdahl"'

1. Effects of long-term statin-treatment on coronary atherosclerosis in patients with inflammatory joint diseases.

Author

Mona Svanteson, Silvia Rollefstad, Nils-Einar Kløw, Jonny Hisdal, Eirik Ikdahl, Joseph Sexton, Ylva Haig, and Anne Grete Semb

Subjects
Medicine, Science
Abstract

BACKGROUND:The effect of statins over time on coronary atherosclerosis in patients with inflammatory joint diseases (IJD) is unknown. Our aim was to evaluate the change in coronary plaque morphology and volume in long-term statin-treated patients with IJD. METHODS:Sixty-eight patients with IJD and carotid artery plaque(s) underwent coronary computed tomography angiography before and after a mean of 4.7 (range 4.0-6.0) years of statin treatment. The treatment target for low density lipoprotein cholesterol (LDL-c) was ≤1.8 mmol/L. Changes in plaque volume (calcified, mixed/soft and total) and coronary artery calcification (CAC) from baseline to follow-up were assessed using the 17-segment American Heart Association-model. RESULTS:Median (IQR) increase in CAC after statin treatment was 38 (5-236) Agatston units (p1.8mmol/L (21 [2-143] vs. 69 [16-423], p = 0.006 and 0.65 [-1.0-13.9] vs. 13.0 [0.0-60.8] mm3, p = 0.019, respectively). CONCLUSIONS:A progression of total atherosclerotic plaque volume in statin-treated patients with IJD was observed. However, soft/mixed plaque volume was reduced, suggesting an alteration in plaque composition. Patients with recommended LDL-c levels at follow-up had reduced atherosclerotic progression compared to patients with LDL-c levels above the treatment target, suggesting a beneficial effect of treatment to guideline-recommended lipid targets in IJD patients.

Published
2019
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2. Sustained Improvement of Arterial Stiffness and Blood Pressure after Long-Term Rosuvastatin Treatment in Patients with Inflammatory Joint Diseases: Results from the RORA-AS Study.

Author

Eirik Ikdahl, Silvia Rollefstad, Jonny Hisdal, Inge C Olsen, Terje R Pedersen, Tore K Kvien, and Anne Grete Semb

Subjects
Medicine, Science
Abstract

OBJECTIVE:Patients with inflammatory joint diseases (IJD) have a high prevalence of hypertension and increased arterial stiffness. The aim of the present study was to evaluate the effect of long-term rosuvastatin treatment on arterial stiffness, measured by augmentation index (AIx) and aortic pulse wave velocity (aPWV), and blood pressure (BP) in IJD patients with established atherosclerosis. METHODS:Eighty-nine statin naïve IJD patients with carotid atherosclerotic plaque(s) (rheumatoid arthritis n = 55, ankylosing spondylitis n = 23, psoriatic arthritis n = 11) received rosuvastatin for 18 months to achieve low-density lipoprotein cholesterol goal ≤1.8 mmol/L. Change in AIx (ΔAIx), aPWV (ΔaPWV), systolic BP (ΔsBP) and diastolic BP (ΔdBP) from baseline to study end was assessed by paired samples t-tests. Linear regression was applied to evaluate associations between cardiovascular disease (CVD) risk factors, rheumatic disease specific variables and medication, and ΔAIx, ΔaPWV, ΔsBP and ΔdBP. RESULTS:AIx, aPWV, sBP and dBP were significantly reduced from baseline to study end. The mean (95%CI) changes were: ΔAIx: -0.34 (-0.03, -0.65)% (p = 0.03), ΔaPWV: -1.69 (-0.21, -3.17) m/s2 (p = 0.03), ΔsBP: -5.27 (-1.61, -8.93) mmHg (p = 0.004) and ΔdBP -2.93 (-0.86, -5.00) mmHg (p = 0.01). In linear regression models, ∆aPWV was significantly correlated with ΔsBP and ΔdBP (for all: p

Published
2016
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3. Effects of long-term statin-treatment on coronary atherosclerosis in patients with inflammatory joint diseases

Author

Jonny Hisdal, Joseph O. Sexton, Ylva Haig, Silvia Rollefstad, Mona Svanteson, Anne Grete Semb, Nils-Einar Kløw, and Eirik Ikdahl

Subjects
Male, Computed Tomography Angiography, Ankylosing Spondylitis, Coronary Artery Disease, 030204 cardiovascular system & hematology, Cardiovascular Medicine, Pathology and Laboratory Medicine, Biochemistry, Vascular Medicine, chemistry.chemical_compound, 0302 clinical medicine, Medicine and Health Sciences, Coronary Heart Disease, Immune Response, Computed tomography angiography, Multidisciplinary, medicine.diagnostic_test, Drugs, Middle Aged, Lipids, Carotid artery plaque, Treatment Outcome, Cardiovascular Diseases, Cardiology, Medicine, Female, medicine.symptom, Joint Diseases, Research Article, medicine.medical_specialty, Inflammatory Diseases, Lipoproteins, Science, Immunology, Inflammation, Autoimmune Diseases, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Internal medicine, medicine, Humans, In patient, Coronary atherosclerosis, 030203 arthritis & rheumatology, Pharmacology, Cholesterol, business.industry, Statins, Biology and Life Sciences, Proteins, Cholesterol, LDL, Statin treatment, Atherosclerosis, chemistry, Coronary artery calcification, Clinical Immunology, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Clinical Medicine, business
Abstract

Background The effect of statins over time on coronary atherosclerosis in patients with inflammatory joint diseases (IJD) is unknown. Our aim was to evaluate the change in coronary plaque morphology and volume in long-term statin-treated patients with IJD. Methods Sixty-eight patients with IJD and carotid artery plaque(s) underwent coronary computed tomography angiography before and after a mean of 4.7 (range 4.0–6.0) years of statin treatment. The treatment target for low density lipoprotein cholesterol (LDL-c) was ≤1.8 mmol/L. Changes in plaque volume (calcified, mixed/soft and total) and coronary artery calcification (CAC) from baseline to follow-up were assessed using the 17-segment American Heart Association-model. Results Median (IQR) increase in CAC after statin treatment was 38 (5–236) Agatston units (p1.8mmol/L (21 [2–143] vs. 69 [16–423], p = 0.006 and 0.65 [-1.0–13.9] vs. 13.0 [0.0–60.8] mm3, p = 0.019, respectively). Conclusions A progression of total atherosclerotic plaque volume in statin-treated patients with IJD was observed. However, soft/mixed plaque volume was reduced, suggesting an alteration in plaque composition. Patients with recommended LDL-c levels at follow-up had reduced atherosclerotic progression compared to patients with LDL-c levels above the treatment target, suggesting a beneficial effect of treatment to guideline-recommended lipid targets in IJD patients.

Published
2019

4. Sustained Improvement of Arterial Stiffness and Blood Pressure after Long-Term Rosuvastatin Treatment in Patients with Inflammatory Joint Diseases: Results from the RORA-AS Study

Author

Terje R. Pedersen, Silvia Rollefstad, Inge C. Olsen, Eirik Ikdahl, Anne Grete Semb, Tore K Kvien, and Jonny Hisdal

Subjects
Male, Ankylosing Spondylitis, Arthritis, lcsh:Medicine, Blood Pressure, 030204 cardiovascular system & hematology, Cardiovascular Medicine, Vascular Medicine, Stiffness, Arthritis, Rheumatoid, 0302 clinical medicine, Mathematical and Statistical Techniques, Risk Factors, Medicine and Health Sciences, Rosuvastatin Calcium, lcsh:Science, Pulse wave velocity, Aorta, Multidisciplinary, Drugs, Middle Aged, Cardiovascular Diseases, Physical Sciences, Cardiology, Regression Analysis, Female, Joint Diseases, Statistics (Mathematics), medicine.drug, Research Article, medicine.medical_specialty, Statin, medicine.drug_class, Materials Science, Material Properties, Immunology, Diastole, Rheumatoid Arthritis, Pulse Wave Analysis, Linear Regression Analysis, Research and Analysis Methods, Autoimmune Diseases, 03 medical and health sciences, Vascular Stiffness, Rheumatology, Internal medicine, medicine, Humans, Mechanical Properties, Rosuvastatin, Spondylitis, Ankylosing, Statistical Methods, Aged, 030203 arthritis & rheumatology, Inflammation, Pharmacology, business.industry, Arthritis, Psoriatic, lcsh:R, Statins, Biology and Life Sciences, Blood Pressure Determination, Cholesterol, LDL, medicine.disease, Atherosclerosis, Surgery, Blood pressure, Arterial stiffness, Clinical Immunology, lcsh:Q, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Clinical Medicine, business, Mathematics, Antihypertensives
Abstract

Objective Patients with inflammatory joint diseases (IJD) have a high prevalence of hypertension and increased arterial stiffness. The aim of the present study was to evaluate the effect of long-term rosuvastatin treatment on arterial stiffness, measured by augmentation index (AIx) and aortic pulse wave velocity (aPWV), and blood pressure (BP) in IJD patients with established atherosclerosis. Methods Eighty-nine statin naive IJD patients with carotid atherosclerotic plaque(s) (rheumatoid arthritis n = 55, ankylosing spondylitis n = 23, psoriatic arthritis n = 11) received rosuvastatin for 18 months to achieve low-density lipoprotein cholesterol goal ≤1.8 mmol/L. Change in AIx (ΔAIx), aPWV (ΔaPWV), systolic BP (ΔsBP) and diastolic BP (ΔdBP) from baseline to study end was assessed by paired samples t-tests. Linear regression was applied to evaluate associations between cardiovascular disease (CVD) risk factors, rheumatic disease specific variables and medication, and ΔAIx, ΔaPWV, ΔsBP and ΔdBP. Results AIx, aPWV, sBP and dBP were significantly reduced from baseline to study end. The mean (95%CI) changes were: ΔAIx: -0.34 (-0.03, -0.65)% (p = 0.03), ΔaPWV: -1.69 (-0.21, -3.17)m/s2 (p = 0.03), ΔsBP: -5.27 (-1.61, -8.93)mmHg (p = 0.004) and ΔdBP -2.93 (-0.86, -5.00)mmHg (p = 0.01). In linear regression models, ∆aPWV was significantly correlated with ΔsBP and ΔdBP (for all: p

Published
2016

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