1. Aliskiren Prevents the Toxic Effects of Peritoneal Dialysis Fluids during Chronic Dialysis in Rats
- Author
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Jesús Masiá, Syong H. Nam-Cha, Juan Pérez-Martínez, Esther Simarro, Agustín Ortega, Francisco C. Pérez-Martínez, Valentín Ceña, and Blanca Carrión
- Subjects
Male ,Time Factors ,medicine.medical_treatment ,lcsh:Medicine ,Pharmacology ,Cardiovascular ,Biochemistry ,Rats, Sprague-Dawley ,Renin-Angiotensin System ,chemistry.chemical_compound ,Fumarates ,Fibrosis ,Molecular Cell Biology ,Chronic Kidney Disease ,Ascites ,Renal Transplantation ,Medicine ,lcsh:Science ,Peritoneal Fibrosis ,Multidisciplinary ,Cell Death ,Clinical Pharmacology ,medicine.anatomical_structure ,Nephrology ,Hypertension ,Peritoneum ,medicine.symptom ,Peritoneal Dialysis ,Research Article ,Drugs and Devices ,medicine.medical_specialty ,Drug Research and Development ,Inflammation ,Peritoneal dialysis ,In vivo ,Internal medicine ,Animals ,Biology ,Dose-Response Relationship, Drug ,business.industry ,lcsh:R ,Biological Transport ,Epithelial Cells ,Aliskiren ,medicine.disease ,Amides ,Rats ,Glucose ,Endocrinology ,chemistry ,Cytoprotection ,lcsh:Q ,business ,Dialysis ,Biomarkers - Abstract
The benefits of long-term peritoneal dialysis (PD) in patients with end-stage renal failure are short-lived due to structural and functional changes in the peritoneal membrane. In this report, we provide evidence for the in vitro and in vivo participation of the renin-angiotensin-aldosterone system (RAAS) in the signaling pathway leading to peritoneal fibrosis during PD. Exposure to high-glucose PD fluids (PDFs) increases damage and fibrosis markers in both isolated rat peritoneal mesothelial cells and in the peritoneum of rats after chronic dialysis. In both cases, the addition of the RAAS inhibitor aliskiren markedly improved damage and fibrosis markers, and prevented functional modifications in the peritoneal transport, as measured by the peritoneal equilibrium test. These data suggest that inhibition of the RAAS may be a novel way to improve the efficacy of PD by preventing inflammation and fibrosis following peritoneal exposure to high-glucose PDFs.
- Published
- 2012
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