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Your search keyword '"Hiroshi Sekiyama"' showing total 3 results
Start Over Author "Hiroshi Sekiyama" Publisher public library of science (plos)
3 results on '"Hiroshi Sekiyama"'

1. Possible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis.

Author

Satoshi Ito, Tomohisa Nagoshi, Kosuke Minai, Yusuke Kashiwagi, Hiroshi Sekiyama, Akira Yoshii, Haruka Kimura, Yasunori Inoue, Kazuo Ogawa, Toshikazu D Tanaka, Takayuki Ogawa, Makoto Kawai, and Michihiro Yoshimura

Subjects
Medicine, Science
Abstract

OBJECTIVE:Although glucose-insulin-potassium (GIK) therapy ought to be beneficial for ischemic heart disease in general, variable outcomes in many clinical trials of GIK in acute coronary syndrome (ACS) had a controversial impact. This study was designed to examine whether "insulin resistance" is involved in ACS and to clarify other potential intrinsic compensatory mechanisms for GIK tolerance through highly statistical procedure. METHODS AND RESULTS:We compared the degree of insulin resistance during ACS attack and remission phase after treatment in individual patients (n = 104). During ACS, homeostasis model assessment of insulin resistance (HOMA-IR) values were significantly increased (P

Published
2017
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2. The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study.

Author

Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Kimiaki Komukai, Toshikazu Tanaka, Kazuo Ogawa, Tomohisa Nagoshi, Satoshi Arase, Satoshi Morimoto, Yasunori Inoue, Hiroshi Sekiyama, Akihiro Urabe, Seiichiro Matsuo, Kenichi Hongo, and Michihiro Yoshimura

Subjects
Medicine, Science
Abstract

OBJECTIVE: Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in stable patients with IHD and compared to stable patients with cardiovascular diseases other than IHD. METHODS: The study population was 2088 patients (1698 males and 390 females) who were admitted to our hospital due to IHD (n = 1,661) and non-IHD (n = 427) and underwent cardiac catheterization. Measurements of the hemodynamic parameters and blood sampling were performed. RESULTS: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p

Published
2014
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3. The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study

Author

Kimiaki Komukai, Michihiro Yoshimura, Toshikazu Tanaka, Kosuke Minai, Satoshi Arase, Tomohisa Nagoshi, Satoshi Morimoto, Takayuki Ogawa, Makoto Kawai, Kenichi Hongo, Hiroshi Sekiyama, Yasunori Inoue, Seiichiro Matsuo, Akihiro Urabe, and Kazuo Ogawa

Subjects
Male, Cardiac Catheterization, Epidemiology, Myocardial Ischemia, lcsh:Medicine, Coronary Artery Disease, Vascular Medicine, Ventricular Function, Left, Body Mass Index, Natriuretic Peptide, Brain, Natriuretic peptide, Medicine and Health Sciences, Coronary Heart Disease, Prospective cohort study, lcsh:Science, Multidisciplinary, Ejection fraction, Atrial fibrillation, Middle Aged, Brain natriuretic peptide, Cardiovascular Diseases, Cardiology, Population study, Regression Analysis, Female, Research Article, medicine.medical_specialty, medicine.drug_class, Internal medicine, medicine, Humans, cardiovascular diseases, Cardiovascular Disease Epidemiology, Aged, Retrospective Studies, Heart Failure, business.industry, lcsh:R, Cardiovascular Disease Risk, medicine.disease, Atherosclerosis, Surgery, Biomarker Epidemiology, Logistic Models, Heart failure, lcsh:Q, business, Biomarkers, Blood sampling, Ejection Fraction
Abstract

OBJECTIVE: Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in stable patients with IHD and compared to stable patients with cardiovascular diseases other than IHD. METHODS: The study population was 2088 patients (1698 males and 390 females) who were admitted to our hospital due to IHD (n = 1,661) and non-IHD (n = 427) and underwent cardiac catheterization. Measurements of the hemodynamic parameters and blood sampling were performed. RESULTS: The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p

Published
2014

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