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Your search keyword '"Ibon Tamayo-Uria"' showing total 2 results
Start Over Author "Ibon Tamayo-Uria" Publisher public library of science (plos)
2 results on '"Ibon Tamayo-Uria"'

1. Risk factors for central nervous system tumors in children: New findings from a case-control study.

Author

Rebeca Ramis, Ibon Tamayo-Uria, Diana Gómez-Barroso, Gonzalo López-Abente, Antonio Morales-Piga, Elena Pardo Romaguera, Nuria Aragonés, and Javier García-Pérez

Subjects
Medicine, Science
Abstract

BACKGROUND:Central nervous system tumors (CNS) are the most frequent solid tumor in children. Causes of CNS tumors are mainly unknown and only 5% of the cases can be explained by genetic predisposition. We studied the effects of environmental exposure on the incidence of CNS tumors in children by subtype, according to exposure to industrial and/or urban environment, exposure to crops and according to socio-economic status of the child. METHODS:We carried out a population-based case-control study of CNS tumors in Spain, covering 714 incident cases collected from the Spanish Registry of Childhood Tumors (period 1996-2011) and 4284 controls, individually matched by year of birth, sex, and autonomous region of residence. We built a covariate to approximate the exposure to industrial and/or urban environment and a covariate for the exposure to crops (GCI) using the coordinates of the home addresses of the children. We used the 2001 Census to obtain information about socio-economic status (SES). We fitted logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs). RESULTS:The results for all CNS tumors showed an excess risk (OR = 1.37; 95%CI = 1.09-1.73) for SES, i.e., children living in the least deprived areas had 37% more risk of CNS tumor than children living in the most deprived areas. For GCI, an increase of 10% in crop surface in the 1-km buffer around the residence implied an increase of 22% in the OR (OR = 1.22; 95%CI = 1.15-1.29). Children living in the intersection of industrial and urban areas could have a greater risk of CNS tumors than children who live outside these areas (OR = 1.20; 95%CI = 0.82-1.77). Living in urban areas (OR = 0.90; 95%CI = 0.65-1.24) or industrial areas (OR = 0.96; 95%CI = 0.81-1.77) did not seem to increase the risk for all CNS tumors together. By subtype, Astrocytomas, Intracranial and intraspinal embryonal tumors, and other gliomas showed similar results. CONCLUSION:Our results suggest that higher socioeconomic status and exposure to crops could increase the risk of CNS tumors in children.

Published
2017
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2. Risk factors for central nervous system tumors in children: New findings from a case-control study

Author

Gonzalo López-Abente, Javier García-Pérez, Ibon Tamayo-Uria, Antonio Morales-Piga, Nuria Aragonés, Elena Pardo Romaguera, Rebeca Ramis, Diana Gómez-Barroso, Instituto de Salud Carlos III, and Asociación Española Contra el Cáncer

Subjects
Central Nervous System, Male, Urban Population, Social Sciences, lcsh:Medicine, Nervous System, Urban Environments, Central Nervous System Neoplasms, Families, 0302 clinical medicine, Sociology, Risk Factors, Epidemiology of cancer, Medicine and Health Sciences, Medicine, 030212 general & internal medicine, lcsh:Science, Child, Neurological Tumors, Children, Geographic Areas, Air Pollutants, Multidisciplinary, Geography, Agriculture, Glioma, Plants, Terrestrial Environments, Oncology, Neurology, 030220 oncology & carcinogenesis, Child, Preschool, Female, Anatomy, Infants, Research Article, Urban Areas, medicine.medical_specialty, Adolescent, Crops, Astrocytoma, Fruits, 03 medical and health sciences, Humans, Social Stratification, Pesticides, Sistema nerviós central, business.industry, Ecology and Environmental Sciences, lcsh:R, Organisms, Case-control study, Infant, Newborn, Biology and Life Sciences, Cancers and Neoplasms, Cancer, Infant, Environmental Exposure, medicine.disease, Social Class, Age Groups, Central nervous system, Family medicine, Case-Control Studies, People and Places, Earth Sciences, Population Groupings, lcsh:Q, business, Crop Science
Abstract

BACKGROUND: Central nervous system tumors (CNS) are the most frequent solid tumor in children. Causes of CNS tumors are mainly unknown and only 5% of the cases can be explained by genetic predisposition. We studied the effects of environmental exposure on the incidence of CNS tumors in children by subtype, according to exposure to industrial and/or urban environment, exposure to crops and according to socio-economic status of the child. METHODS: We carried out a population-based case-control study of CNS tumors in Spain, covering 714 incident cases collected from the Spanish Registry of Childhood Tumors (period 1996-2011) and 4284 controls, individually matched by year of birth, sex, and autonomous region of residence. We built a covariate to approximate the exposure to industrial and/or urban environment and a covariate for the exposure to crops (GCI) using the coordinates of the home addresses of the children. We used the 2001 Census to obtain information about socio-economic status (SES). We fitted logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs). RESULTS: The results for all CNS tumors showed an excess risk (OR = 1.37; 95%CI = 1.09-1.73) for SES, i.e., children living in the least deprived areas had 37% more risk of CNS tumor than children living in the most deprived areas. For GCI, an increase of 10% in crop surface in the 1-km buffer around the residence implied an increase of 22% in the OR (OR = 1.22; 95%CI = 1.15-1.29). Children living in the intersection of industrial and urban areas could have a greater risk of CNS tumors than children who live outside these areas (OR = 1.20; 95%CI = 0.82-1.77). Living in urban areas (OR = 0.90; 95%CI = 0.65-1.24) or industrial areas (OR = 0.96; 95%CI = 0.81-1.77) did not seem to increase the risk for all CNS tumors together. By subtype, Astrocytomas, Intracranial and intraspinal embryonal tumors, and other gliomas showed similar results. CONCLUSION: Our results suggest that higher socioeconomic status and exposure to crops could increase the risk of CNS tumors in children. This study was funded by Spain's Health Research Fund (Fondo de Investigación Sanitaria - FIS 12/01416) and Scientific Foundation of the Spanish Association Against Cancer (Fundación Científica de la Asociación Española Contra el Cáncer (AECC) – EVP-1178/14). Sí

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