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Your search keyword '"Jan Spindler"' showing total 2 results
Start Over Author "Jan Spindler" Publisher public library of science (plos)
2 results on '"Jan Spindler"'

1. Cytokine profiles in the aqueous humor and serum of patients with dry and treated wet age-related macular degeneration.

Author

Jan Spindler, Souska Zandi, Isabel B Pfister, Christin Gerhardt, and Justus G Garweg

Subjects
Medicine, Science
Abstract

PURPOSE:To identify disease-specific cytokine profile differences in the aqueous humor (AH) (other than the vascular endothelial growth factor) between patients with dry and treated wet age-related macular degeneration (AMD) and healthy controls. METHODS:This retrospective study drew on a case-series of patients diagnosed with dry AMD (n = 25) and treated wet AMD (n = 19), as well as on healthy controls (no systemic therapy; n = 20) undergoing phacoemulsification or vitrectomy. Samples of AH and serum were collected in parallel at the beginning of surgery. The levels of 43 cytokines were simultaneously determined using the Bio-Plex® multiplex beads system. Differences between the three groups were statistically compared using the Kruskal-Wallis H-Test after applying the Bonferroni correction for multiple comparisons (p

Published
2018
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2. Cytokine profiles in the aqueous humor and serum of patients with dry and treated wet age-related macular degeneration

Author

Christin Gerhardt, Jan Spindler, Souska Zandi, Isabel B. Pfister, and Justus G. Garweg

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, genetic structures, medicine.medical_treatment, lcsh:Medicine, 610 Medicine & health, Vitrectomy, Inflammation, Gastroenterology, Aqueous Humor, Pathogenesis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Humans, lcsh:Science, Aged, Retrospective Studies, Aged, 80 and over, Multidisciplinary, biology, business.industry, lcsh:R, Case-control study, Macular degeneration, medicine.disease, eye diseases, Vascular endothelial growth factor, 030104 developmental biology, Cytokine, chemistry, Case-Control Studies, CXCL6, Wet Macular Degeneration, 030221 ophthalmology & optometry, biology.protein, Cytokines, Female, lcsh:Q, sense organs, medicine.symptom, business
Abstract

Purpose To identify disease-specific cytokine profile differences in the aqueous humor (AH) (other than the vascular endothelial growth factor) between patients with dry and treated wet age-related macular degeneration (AMD) and healthy controls. Methods This retrospective study drew on a case-series of patients diagnosed with dry AMD (n = 25) and treated wet AMD (n = 19), as well as on healthy controls (no systemic therapy; n = 20) undergoing phacoemulsification or vitrectomy. Samples of AH and serum were collected in parallel at the beginning of surgery. The levels of 43 cytokines were simultaneously determined using the Bio-Plex® multiplex beads system. Differences between the three groups were statistically compared using the Kruskal-Wallis H-Test after applying the Bonferroni correction for multiple comparisons (p

Published
2018
Full Text
View/download PDF

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