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Start Over Author "Jiuling Yang" Publisher public library of science (plos)
2 results on '"Jiuling Yang"'

1. LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma.

Author

Guojun Zhai, Kaowen Yan, Xiaoxu Ji, Wenrui Xu, Jiuling Yang, Fuxia Xiong, Jing Su, Michael A McNutt, and Hua Yang

Subjects
Medicine, Science
Abstract

BACKGROUND: Lysosomal protein transmembrane 4 beta (LAPTM4B) is a novel cancer-related gene which has two alleles designated LAPTM4B*1 and LAPTM4B*2. In this study we investigated the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who had undergone curative resection for gallbladder carcinoma (GBC). METHODOLOGY/PRINCIPAL FINDINGS: PCR assay was performed to determine the LAPTM4B genotype in 85 patients. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan-Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P

Published
2012
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2. LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma

Author

Xiaoxu Ji, Hua Yang, Jing Su, Michael A. McNutt, Wenrui Xu, Guojun Zhai, Jiuling Yang, Kaowen Yan, and Fuxia Xiong

Subjects
Male, Pathology, Epidemiology, lcsh:Medicine, Kaplan-Meier Estimate, Gastroenterology, Polymerase Chain Reaction, LAPTM4B, Risk Factors, Genotype, lcsh:Science, Oncogene Proteins, Molecular Epidemiology, Multidisciplinary, Middle Aged, Prognosis, medicine.anatomical_structure, Oncology, Medicine, Female, Gallbladder Neoplasms, Cancer Epidemiology, Research Article, Adult, medicine.medical_specialty, Risk Assessment, Diagnostic Medicine, Internal medicine, Gastrointestinal Tumors, medicine, Carcinoma, Genetics, Cancer Genetics, Biomarkers, Tumor, Humans, Allele, Gene, Biology, Alleles, Aged, Proportional Hazards Models, Chi-Square Distribution, business.industry, Proportional hazards model, Gallbladder, lcsh:R, Cancers and Neoplasms, Gallbladder Cancer, Membrane Proteins, medicine.disease, Biomarker Epidemiology, Multivariate Analysis, lcsh:Q, Gallbladder Neoplasm, business, Biomarkers, General Pathology
Abstract

BACKGROUND: Lysosomal protein transmembrane 4 beta (LAPTM4B) is a novel cancer-related gene which has two alleles designated LAPTM4B*1 and LAPTM4B*2. In this study we investigated the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who had undergone curative resection for gallbladder carcinoma (GBC). METHODOLOGY/PRINCIPAL FINDINGS: PCR assay was performed to determine the LAPTM4B genotype in 85 patients. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan-Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P

Published
2012

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