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2 results on '"Lion Poles"'

1. Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices

Author

Haitham Abu Khadija, Gera Gandelman, Omar Ayyad, Mustafa Jaber, Lion Poles, Michael Jonas, Offir Paz, Firas Abu Sbaih, Gal Sella, Sara Shimoni, Jacob George, and Alex Blatt

Subjects
Medicine, Science
Abstract

Objective Transcatheter aortic valve implantation (TAVI) provokes early injury response, represented in part by dynamic changes in the inflammatory markers. The association of self-expanding valves (SEVs) and balloon-expandable valves (BEVs) with the consequent inflammatory response remains uncertain. Materials and methods Patients with severe symptomatic aortic stenosis who underwent transfemoral TAVI: SEVs or BEVs, from January 2010 to December 2019 were enrolled. Whole white blood cells (WBC) and subpopulation dynamics as well the neutrophil to lymphocyte ratio (NLR) were evaluated. Results Three-hundred seventy consecutive patients (mean age 81.75 ± 6.8 years, 199 women’s) were enrolled. In the entire population, significant kinetic changes in the WBC response (p Conclusion This is the first description of a differential inflammatory response between the two leading delivery systems. SEV appears to trigger a more robust inflammatory response as compared to BEV. Clinical studies are warranted to assess the long term effect of our findings.

Published
2021

2. Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices

Author

Sara Shimoni, Lion Poles, Gera Gandelman, Haitham Abu Khadija, Michael Jonas, Gal Sella, Mustafa Jaber, Alex Blatt, Omar Ayyad, Firas Abu Sbaih, Jacob George, and Offir Paz

Subjects
Male, Medical Implants, Neutrophils, Cardiovascular Procedures, Monocytes, White Blood Cells, Postoperative Complications, Animal Cells, Medicine and Health Sciences, Medicine, Term effect, Lymphocytes, Immune Response, Aged, 80 and over, Coronary Artery Bypass Grafting, Multidisciplinary, Systemic Inflammatory Response Syndrome, Treatment Outcome, Balloon expandable stent, Heart Valve Prosthesis, Cardiology, Absolute neutrophil count, Engineering and Technology, Female, Cellular Types, medicine.symptom, Research Article, Biotechnology, medicine.medical_specialty, Immune Cells, Science, Immunology, Bioengineering, Surgical and Invasive Medical Procedures, Inflammation, Transcatheter Aortic Valve Replacement, Signs and Symptoms, Sepsis, Internal medicine, Humans, Neutrophil to lymphocyte ratio, Symptomatic aortic stenosis, Aged, Entire population, Blood Cells, business.industry, Biology and Life Sciences, Aortic Valve Stenosis, Cell Biology, medicine.disease, Systemic inflammatory response syndrome, Medical Devices and Equipment, Clinical Medicine, business
Abstract

Objective Transcatheter aortic valve implantation (TAVI) provokes early injury response, represented in part by dynamic changes in the inflammatory markers. The association of self-expanding valves (SEVs) and balloon-expandable valves (BEVs) with the consequent inflammatory response remains uncertain. Materials and methods Patients with severe symptomatic aortic stenosis who underwent transfemoral TAVI: SEVs or BEVs, from January 2010 to December 2019 were enrolled. Whole white blood cells (WBC) and subpopulation dynamics as well the neutrophil to lymphocyte ratio (NLR) were evaluated. Results Three-hundred seventy consecutive patients (mean age 81.75 ± 6.8 years, 199 women’s) were enrolled. In the entire population, significant kinetic changes in the WBC response (p Conclusion This is the first description of a differential inflammatory response between the two leading delivery systems. SEV appears to trigger a more robust inflammatory response as compared to BEV. Clinical studies are warranted to assess the long term effect of our findings.

Published
2021

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