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Your search keyword '"Marlucia da Silva Garrido"' showing total 3 results
Start Over Author "Marlucia da Silva Garrido" Publisher public library of science (plos)
3 results on '"Marlucia da Silva Garrido"'

1. Mycobacterium tuberculosis infection in young children: analyzing the performance of the diagnostic tests.

Author

Tomàs M Pérez-Porcuna, Carlos Ascaso, Adriana Malheiro, Rosa Abellana, Marilaine Martins, José Felipe Jardim Sardinha, Patricia Quincó, Irineide Assumpção Antunes, Marlucia da Silva Garrido, Samira Bührer-Sékula, and Flor Ernestina Martinez-Espinosa

Subjects
Medicine, Science
Abstract

OBJECTIVE:This study evaluated the performance of the Tuberculin Skin Test (TST) and Quantiferon-TB Gold in-Tube (QFT) and the possible association of factors which may modify their results in young children (0-6 years) with recent contact with an index tuberculosis case. MATERIALS AND METHODS:A cross-sectional study including 135 children was conducted in Manaus, Amazonas-Brazil. The TST and QFT were performed and the tests results were analyzed in relation to the personal characteristics of the children studied and their relationship with the index case. RESULTS:The rates of positivity were 34.8% (TST) and 26.7% (QFT), with 14.1% of indeterminations by the QFT. Concordance between tests was fair (Kappa = 0.35 P

Published
2014
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2. Factors associated with tuberculosis treatment default in an endemic area of the Brazilian Amazon: a case control-study.

Author

Marlucia da Silva Garrido, Maria Lucia Penna, Tomàs M Perez-Porcuna, Alexandra Brito de Souza, Leni da Silva Marreiro, Bernardino Claudio Albuquerque, Flor Ernestina Martínez-Espinosa, and Samira Bührer-Sékula

Subjects
Medicine, Science
Abstract

SETTING: Treatment default is a serious problem in tuberculosis control because it implies persistence of infection source, increased mortality, increased relapse rates and facilitates the development of resistant strains. OBJECTIVE: This study analyzed tuberculosis treatment default determinants in the Amazonas State to contribute in planning appropriate control interventions. DESIGN: Observational study with a retrospective cohort using Brazilian Disease Notification System data from 2005 to 2010. A nested case control study design was used. Patients defaulting from treatment were considered as 'cases' and those completing treatment as 'controls'. In the analysis, 11,312 tuberculosis patients were included, 1,584 cases and 9,728 controls. RESULTS: Treatment default was observed to be associated to previous default (aOR 3.20; p

Published
2012
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3. Mycobacterium tuberculosis Infection in Young Children: Analyzing the Performance of the Diagnostic Tests

Author

Carlos Ascaso, Irineide Assumpção Antunes, José Felipe Jardim Sardinha, Tomàs M. Pérez-Porcuna, Adriana Malheiro, Marlucia da Silva Garrido, Marilaine Martins, Patricia Quinco, Samira Bührer-Sékula, Flor Ernestina Martinez-Espinosa, Rosa Abellana, and Universitat de Barcelona

Subjects
Male, Bacterial Diseases, Epidemiology, lcsh:Medicine, Pathology and Laboratory Medicine, Global Health, Biochemistry, Pediatrics, Gastroenterology, Medicine and Health Sciences, Public and Occupational Health, Child, lcsh:Science, Index case, Multidisciplinary, biology, Vaccination, Child Health, Mycobacterium bovis, Infectious Diseases, Research Design, Child, Preschool, Female, Research Article, Infància, Adult, medicine.medical_specialty, Tuberculosis, Adolescent, Clinical Research Design, Tuberculosi, Concordance, Immunology, Tuberculin, Research and Analysis Methods, Infectious Disease Epidemiology, Mycobacterium tuberculosis, Interferon-gamma, Tuberculosis diagnosis, Diagnostic Medicine, Internal medicine, Helminths, medicine, Humans, Helmints, Tuberculin Test, business.industry, lcsh:R, Infant, Newborn, Infant, Biology and Life Sciences, Tropical Diseases, medicine.disease, biology.organism_classification, bacterial infections and mycoses, Childhood, Ferritin, Cross-Sectional Studies, biology.protein, Clinical Immunology, lcsh:Q, business, Biomarkers, Kappa
Abstract

Objective: This study evaluated the performance of the Tuberculin Skin Test (TST) and Quantiferon-TB Gold in-Tube (QFT) and the possible association of factors which may modify their results in young children (0–6 years) with recent contact with an index tuberculosis case. Materials and Methods: A cross-sectional study including 135 children was conducted in Manaus, Amazonas-Brazil. The TST and QFT were performed and the tests results were analyzed in relation to the personal characteristics of the children studied and their relationship with the index case. Results: The rates of positivity were 34.8% (TST) and 26.7% (QFT), with 14.1% of indeterminations by the QFT. Concordance between tests was fair (Kappa = 0.35 P,0.001). Both the TST and QFT were associated with the intensity of exposure (Linear OR = 1.286, P = 0.005; Linear OR = 1.161, P = 0.035 respectively) with only the TST being associated with the time of exposure (Linear OR = 1.149, P = 0.009). The presence of intestinal helminths in the TST+ group was associated with negative QFT results (OR = 0.064, P = 0.049). In the TST2 group lower levels of ferritin were associated with QFT+ results (Linear OR = 0.956, P = 0.036). Conclusions: Concordance between the TST and QFT was lower than expected. The factors associated with the discordant results were intestinal helminths, ferritin levels and exposure time to the index tuberculosis case. In TST+ group, helminths were associated with negative QFT results suggesting impaired cell-mediated immunity. The TST2&QFT+ group had a shorter exposure time and lower ferritin levels, suggesting that QFT is faster and ferritin may be a potential biomarker of early stages of tuberculosis infection.

Published
2014

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