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Your search keyword '"Sena, Emily S."' showing total 22 results
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22 results on '"Sena, Emily S."'

1. Community consensus on core open science practices to monitor in biomedicine

Author

Cobey, Kelly D., primary, Haustein, Stefanie, additional, Brehaut, Jamie, additional, Dirnagl, Ulrich, additional, Franzen, Delwen L., additional, Hemkens, Lars G., additional, Presseau, Justin, additional, Riedel, Nico, additional, Strech, Daniel, additional, Alperin, Juan Pablo, additional, Costas, Rodrigo, additional, Sena, Emily S., additional, van Leeuwen, Thed, additional, Ardern, Clare L., additional, Bacellar, Isabel O. L., additional, Camack, Nancy, additional, Britto Correa, Marcos, additional, Buccione, Roberto, additional, Cenci, Maximiliano Sergio, additional, Fergusson, Dean A., additional, Gould van Praag, Cassandra, additional, Hoffman, Michael M., additional, Moraes Bielemann, Renata, additional, Moschini, Ugo, additional, Paschetta, Mauro, additional, Pasquale, Valentina, additional, Rac, Valeria E., additional, Roskams-Edris, Dylan, additional, Schatzl, Hermann M., additional, Stratton, Jo Anne, additional, and Moher, David, additional

Published
2023
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2. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Author

Percie Du Sert, Nathalie, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T., Baker, Monya, Browne, William J., Clark, Alejandra, Cuthill, Innes C., Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T., Howells, David W., Hurst, Viki, Karp, Natasha A., Lazic, Stanley E., Lidster, Katie, MacCallum, Catriona J., Macleod, Malcolm, Pearl, Esther J., Petersen, Ole H., Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S., Silberberg, Shai D., Steckler, Thomas, Würbel, Hanno, and Boutron, Isabelle

Subjects
0301 basic medicine, Life Sciences & Biomedicine - Other Topics, LABORATORY-ANIMALS, Research Validity, Research Facilities, Knowledge management, Mathematical and Statistical Techniques, 0302 clinical medicine, w_20.55, Health care, Biology (General), Reliability (statistics), RESTRAINT STRESS, 11 Medical and Health Sciences, Animal Welfare (journal), DANIO-RERIO, Experimental Design, General Neuroscience, TUMOR-GROWTH, Statistics, Research Assessment, w_20.5, Reproducibility, CONTROLLED-TRIALS, Systematic review, Research Design, Perspective, Physical Sciences, Research Reporting Guidelines, Research Laboratories, General Agricultural and Biological Sciences, Life Sciences & Biomedicine, REGISTERED REPORTS, Biochemistry & Molecular Biology, EXPERIMENTER BIAS, Science Policy, QH301-705.5, Best practice, MEDLINE, Biology, Research and Analysis Methods, General Biochemistry, Genetics and Molecular Biology, qy_25, 03 medical and health sciences, 07 Agricultural and Veterinary Sciences, Statistical Methods, Elaboration, ENVIRONMENTAL ENRICHMENT, Science & Technology, General Immunology and Microbiology, business.industry, TREATMENT ALLOCATION, 06 Biological Sciences, wb_60, Transparency (behavior), SYSTEMATIC REVIEWS, 030104 developmental biology, business, Mathematics, 030217 neurology & neurosurgery, Developmental Biology
Abstract

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the “ARRIVE Essential 10,” which constitutes the minimum requirement, and the “Recommended Set,” which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration (E&E) document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility., The ARRIVE guidelines detail key information to include in any publication describing animal research. This Perspective article describes how the guidelines have been updated and reorganised to facilitate their use in practice.

Published
2020
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3. Epidemiology and reporting characteristics of preclinical systematic reviews

Author

Hunniford, Victoria T., primary, Montroy, Joshua, additional, Fergusson, Dean A., additional, Avey, Marc T., additional, Wever, Kimberley E., additional, McCann, Sarah K., additional, Foster, Madison, additional, Fox, Grace, additional, Lafreniere, Mackenzie, additional, Ghaly, Mira, additional, Mannell, Sydney, additional, Godwinska, Karolina, additional, Gentles, Avonae, additional, Selim, Shehab, additional, MacNeil, Jenna, additional, Sikora, Lindsey, additional, Sena, Emily S., additional, Page, Matthew J., additional, Macleod, Malcolm, additional, Moher, David, additional, and Lalu, Manoj M., additional

Published
2021
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4. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

Author

Percie du Sert, Nathalie, primary, Ahluwalia, Amrita, additional, Alam, Sabina, additional, Avey, Marc T., additional, Baker, Monya, additional, Browne, William J., additional, Clark, Alejandra, additional, Cuthill, Innes C., additional, Dirnagl, Ulrich, additional, Emerson, Michael, additional, Garner, Paul, additional, Holgate, Stephen T., additional, Howells, David W., additional, Hurst, Viki, additional, Karp, Natasha A., additional, Lazic, Stanley E., additional, Lidster, Katie, additional, MacCallum, Catriona J., additional, Macleod, Malcolm, additional, Pearl, Esther J., additional, Petersen, Ole H., additional, Rawle, Frances, additional, Reynolds, Penny, additional, Rooney, Kieron, additional, Sena, Emily S., additional, Silberberg, Shai D., additional, Steckler, Thomas, additional, and Würbel, Hanno, additional

Published
2020
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5. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Author

Percie du Sert, Nathalie, primary, Hurst, Viki, additional, Ahluwalia, Amrita, additional, Alam, Sabina, additional, Avey, Marc T., additional, Baker, Monya, additional, Browne, William J., additional, Clark, Alejandra, additional, Cuthill, Innes C., additional, Dirnagl, Ulrich, additional, Emerson, Michael, additional, Garner, Paul, additional, Holgate, Stephen T., additional, Howells, David W., additional, Karp, Natasha A., additional, Lazic, Stanley E., additional, Lidster, Katie, additional, MacCallum, Catriona J., additional, Macleod, Malcolm, additional, Pearl, Esther J., additional, Petersen, Ole H., additional, Rawle, Frances, additional, Reynolds, Penny, additional, Rooney, Kieron, additional, Sena, Emily S., additional, Silberberg, Shai D., additional, Steckler, Thomas, additional, and Würbel, Hanno, additional

Published
2020
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7. Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis

Author

Currie, Gillian L., primary, Angel-Scott, Helena N., additional, Colvin, Lesley, additional, Cramond, Fala, additional, Hair, Kaitlyn, additional, Khandoker, Laila, additional, Liao, Jing, additional, Macleod, Malcolm, additional, McCann, Sarah K., additional, Morland, Rosie, additional, Sherratt, Nicki, additional, Stewart, Robert, additional, Tanriver-Ayder, Ezgi, additional, Thomas, James, additional, Wang, Qianying, additional, Wodarski, Rachel, additional, Xiong, Ran, additional, Rice, Andrew S. C., additional, and Sena, Emily S., additional

Published
2019
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9. The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis

Author

Chen, Jiarong, Yang, Canhong, Guo, Bin, Sena, Emily S, Macleod, Malcolm R, Yuan, Yawei, and Hirst, Theodore C

Subjects
lcsh:R, lcsh:Medicine, lcsh:Q, skin and connective tissue diseases, lcsh:Science
Abstract

BACKGROUND: Breast cancer is the most frequent cancers and is the second leading cause of cancer death among women. Trastuzumab is an effective treatment, the first monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). To inform the development of other effective treatments we report summary estimates of efficacy of trastuzumab on survival and tumour volume in animal models of breast cancer.METHODS: We searched PubMed and EMBASE systematically to identify publications testing trastuzumab in animal models of breast cancer. Data describing tumour volume, median survival and animal features were extracted and we assessed quality using a 12-item checklist. We analysed the impact of study design and quality and evidence for publication bias.RESULTS: We included data from 83 studies reporting 169 experiments using 2076 mice. Trastuzumab treatment caused a substantial reduction in tumour growth, with tumours in treated animals growing to 32.6% of the volume of tumours in control animals (95%CI 27.8%-38.2%). Median survival was prolonged by a factor of 1.45 (1.30-1.62). Many study design and quality features accounted for between-study heterogeneity and we found evidence suggesting publication bias.CONCLUSION: We have found trastuzumab to be effective in animal breast cancer models across a range of experimental circumstances. However the presence of publication bias and a low prevalence of measures to reduce bias provide a focus for future improvements in preclinical breast cancer research.

Published
2016
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11. Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

Author

Watzlawick, Ralf, primary, Rind, Julian, additional, Sena, Emily S., additional, Brommer, Benedikt, additional, Zhang, Tian, additional, Kopp, Marcel A., additional, Dirnagl, Ulrich, additional, Macleod, Malcolm R., additional, Howells, David W., additional, and Schwab, Jan M., additional

Published
2016
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14. Correction: Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Author

Macleod, Malcolm R., primary, Lawson McLean, Aaron, additional, Kyriakopoulou, Aikaterini, additional, Serghiou, Stylianos, additional, de Wilde, Arno, additional, Sherratt, Nicki, additional, Hirst, Theo, additional, Hemblade, Rachel, additional, Bahor, Zsanett, additional, Nunes-Fonseca, Cristina, additional, Potluru, Aparna, additional, Thomson, Andrew, additional, Baginskaite, Julija, additional, Egan, Kieren, additional, Vesterinen, Hanna, additional, Currie, Gillian L., additional, Churilov, Leonid, additional, Howells, David W., additional, and Sena, Emily S., additional

Published
2015
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15. Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Author

Macleod, Malcolm R., primary, Lawson McLean, Aaron, additional, Kyriakopoulou, Aikaterini, additional, Serghiou, Stylianos, additional, de Wilde, Arno, additional, Sherratt, Nicki, additional, Hirst, Theo, additional, Hemblade, Rachel, additional, Bahor, Zsanett, additional, Nunes-Fonseca, Cristina, additional, Potluru, Aparna, additional, Thomson, Andrew, additional, Baginskitae, Julija, additional, Egan, Kieren, additional, Vesterinen, Hanna, additional, Currie, Gillian L., additional, Churilov, Leonid, additional, Howells, David W., additional, and Sena, Emily S., additional

Published
2015
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16. Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis

Author

Vesterinen, Hanna M., primary, Connick, Peter, additional, Irvine, Cadi M. J., additional, Sena, Emily S., additional, Egan, Kieren J., additional, Carmichael, Gary G., additional, Tariq, Afiyah, additional, Pavitt, Sue, additional, Chataway, Jeremy, additional, Macleod, Malcolm R., additional, and Chandran, Siddharthan, additional

Published
2015
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