Search

Your search keyword '"Yangsong Wang"' showing total 2 results
Start Over "Yangsong Wang" Publisher public library of science (plos)
2 results on '"Yangsong Wang"'

1. IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation.

Author

Murshed H Sarkar, Ryoji Yagi, Yukihiro Endo, Ryo Koyama-Nasu, Yangsong Wang, Ichita Hasegawa, Toshihiro Ito, Ilkka S Junttila, Jinfang Zhu, Motoko Y Kimura, and Toshinori Nakayama

Subjects
Medicine, Science
Abstract

While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully understood. We found that IFNγ decreases the expression of growth factor independent-1 transcriptional repressor (GFI1) in Th2 cells, resulting in the inhibition of Th2 cell proliferation. The deletion of the Gfi1 gene in Th2 cells results in the failure of their proliferation, accompanied by an impaired cell cycle progression. In contrast, the enforced expression of GFI1 restores the defective Th2 cell proliferation, even in the presence of IFNγ. These results demonstrate that GFI1 is a key molecule in the IFNγ-mediated inhibition of Th2 cell proliferation.

Published
2021
Full Text
View/download PDF

2. IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation

Author

Ichita Hasegawa, Murshed H Sarkar, Yukihiro Endo, Toshinori Nakayama, Ilkka Junttila, Ryoji Yagi, Yangsong Wang, Motoko Y. Kimura, Toshihiro Ito, Ryo Koyama-Nasu, Jinfang Zhu, Tampere University, BioMediTech, and Department of Clinical Chemistry

Subjects
Physiology, medicine.medical_treatment, Cell cycle progression, Gene Expression, Mice, White Blood Cells, Animal Cells, Immune Physiology, Medicine and Health Sciences, Cell Cycle and Cell Division, Immune Response, Cells, Cultured, Staining, Innate Immune System, Multidisciplinary, Chemistry, Genetically Modified Organisms, Cell Cycle, Cell Staining, Cell Differentiation, Cell biology, DNA-Binding Proteins, Cytokine, Cell Processes, Transcriptional Repressor, Cytokines, Engineering and Technology, Medicine, Cellular Types, Genetic Engineering, Research Article, Biotechnology, Immune Cells, Science, Immunology, Down-Regulation, Bioengineering, Research and Analysis Methods, Interferon-gamma, Th2 Cells, Immune system, Genetics, medicine, Animals, T Helper Cells, Gene, Cell Proliferation, Blood Cells, Genetically Modified Animals, Cell growth, Growth factor, Biology and Life Sciences, Cell Biology, Molecular Development, Mice, Inbred C57BL, Specimen Preparation and Treatment, Immune System, 3111 Biomedicine, Gene Deletion, Transcription Factors, Developmental Biology
Abstract

While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully understood. We found that IFNγ decreases the expression of growth factor independent-1 transcriptional repressor (GFI1) in Th2 cells, resulting in the inhibition of Th2 cell proliferation. The deletion of theGfi1gene in Th2 cells results in the failure of their proliferation, accompanied by an impaired cell cycle progression. In contrast, the enforced expression of GFI1 restores the defective Th2 cell proliferation, even in the presence of IFNγ. These results demonstrate that GFI1 is a key molecule in the IFNγ-mediated inhibition of Th2 cell proliferation.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results