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Your search keyword '"Yoshikazu Muroya"' showing total 2 results
Start Over Author "Yoshikazu Muroya" Publisher public library of science (plos)
2 results on '"Yoshikazu Muroya"'

1. Chronic Running Exercise Alleviates Early Progression of Nephropathy with Upregulation of Nitric Oxide Synthases and Suppression of Glycation in Zucker Diabetic Rats.

Author

Daisuke Ito, Pengyu Cao, Takaaki Kakihana, Emiko Sato, Chihiro Suda, Yoshikazu Muroya, Yoshiko Ogawa, Gaizun Hu, Tadashi Ishii, Osamu Ito, Masahiro Kohzuki, and Hideyasu Kiyomoto

Subjects
Medicine, Science
Abstract

Exercise training is known to exert multiple beneficial effects including renal protection in type 2 diabetes mellitus and obesity. However, the mechanisms regulating these actions remain unclear. The present study evaluated the effects of chronic running exercise on the early stage of diabetic nephropathy, focusing on nitric oxide synthase (NOS), oxidative stress and glycation in the kidneys of Zucker diabetic fatty (ZDF) rats. Male ZDF rats (6 weeks old) underwent forced treadmill exercise for 8 weeks (Ex-ZDF). Sedentary ZDF (Sed-ZDF) and Zucker lean (Sed-ZL) rats served as controls. Exercise attenuated hyperglycemia (plasma glucose; 242 ± 43 mg/dL in Sed-ZDF and 115 ± 5 mg/dL in Ex-ZDF) with increased insulin secretion (plasma insulin; 2.3 ± 0.7 and 5.3 ± 0.9 ng/mL), reduced albumin excretion (urine albumin; 492 ± 70 and 176 ± 11 mg/g creatinine) and normalized creatinine clearance (9.7 ± 1.4 and 4.5 ± 0.8 mL/min per body weight) in ZDF rats. Endothelial (e) and neuronal (n) NOS expression in kidneys of Sed-ZDF rats were lower compared with Sed-ZL rats (p

Published
2015
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2. Chronic Running Exercise Alleviates Early Progression of Nephropathy with Upregulation of Nitric Oxide Synthases and Suppression of Glycation in Zucker Diabetic Rats

Author

Masahiro Kohzuki, Daisuke Ito, Emiko Sato, Gaizun Hu, Tadashi Ishii, Yoshiko Ogawa, Hideyasu Kiyomoto, Takaaki Kakihana, Osamu Ito, Yoshikazu Muroya, Pengyu Cao, and Chihiro Suda

Subjects
Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, medicine.medical_treatment, Renal function, lcsh:Medicine, Blood Pressure, Nephropathy, Diabetes Mellitus, Experimental, Diabetic nephropathy, chemistry.chemical_compound, Glycation, Internal medicine, Diabetes mellitus, Physical Conditioning, Animal, medicine, Aerobic exercise, Animals, Diabetic Nephropathies, lcsh:Science, Creatinine, Multidisciplinary, business.industry, Insulin, lcsh:R, nutritional and metabolic diseases, medicine.disease, Rats, Rats, Zucker, Endocrinology, chemistry, Disease Progression, lcsh:Q, Nitric Oxide Synthase, business, Research Article
Abstract

Exercise training is known to exert multiple beneficial effects including renal protection in type 2 diabetes mellitus and obesity. However, the mechanisms regulating these actions remain unclear. The present study evaluated the effects of chronic running exercise on the early stage of diabetic nephropathy, focusing on nitric oxide synthase (NOS), oxidative stress and glycation in the kidneys of Zucker diabetic fatty (ZDF) rats. Male ZDF rats (6 weeks old) underwent forced treadmill exercise for 8 weeks (Ex-ZDF). Sedentary ZDF (Sed-ZDF) and Zucker lean (Sed-ZL) rats served as controls. Exercise attenuated hyperglycemia (plasma glucose; 242 ± 43 mg/dL in Sed-ZDF and 115 ± 5 mg/dL in Ex-ZDF) with increased insulin secretion (plasma insulin; 2.3 ± 0.7 and 5.3 ± 0.9 ng/mL), reduced albumin excretion (urine albumin; 492 ± 70 and 176 ± 11 mg/g creatinine) and normalized creatinine clearance (9.7 ± 1.4 and 4.5 ± 0.8 mL/min per body weight) in ZDF rats. Endothelial (e) and neuronal (n) NOS expression in kidneys of Sed-ZDF rats were lower compared with Sed-ZL rats (p

Published
2015

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