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Your search keyword '"Zimic, Mirko"' showing total 20 results
Start Over Author "Zimic, Mirko" Publisher public library of science (plos)
20 results on '"Zimic, Mirko"'

2. Correction: Immunological detection of pyrazine-2-carboxylic acid for the detection of pyrazinamide resistance in Mycobacterium tuberculosis

Author

Florentini, Edgar A., primary, Angulo, Noelia, additional, Gilman, Robert H., additional, Alcántara, Roberto, additional, Roncal, Elisa, additional, Antiparra, Ricardo, additional, Toscano, Emily, additional, Vallejos, Katherine, additional, Kirwan, Daniela E., additional, Zimic, Mirko, additional, and Sheen, Patricia, additional

Published
2021
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3. Genome-wide analyses of human noroviruses provide insights on evolutionary dynamics and evidence of coexisting viral populations evolving under recombination constraints

Author

Tohma, Kentaro, primary, Lepore, Cara J., additional, Martinez, Magaly, additional, Degiuseppe, Juan I., additional, Khamrin, Pattara, additional, Saito, Mayuko, additional, Mayta, Holger, additional, Nwaba, Amy U. Amanda, additional, Ford-Siltz, Lauren A., additional, Green, Kim Y., additional, Galeano, Maria E., additional, Zimic, Mirko, additional, Stupka, Juan A., additional, Gilman, Robert H., additional, Maneekarn, Niwat, additional, Ushijima, Hiroshi, additional, and Parra, Gabriel I., additional

Published
2021
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4. Immunological detection of pyrazine-2-carboxylic acid for the detection of pyrazinamide resistance in Mycobacterium tuberculosis

Author

Florentini, Edgar A., primary, Angulo, Noelia, additional, Gilman, Robert H., additional, Alcántara, Roberto, additional, Roncal, Elisa, additional, Antiparra, Ricardo, additional, Toscano, Emily, additional, Vallejos, Katherine, additional, Kirwan, Danni, additional, Zimic, Mirko, additional, and Sheen, Patricia, additional

Published
2020
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6. Prediction of Mycobacterium tuberculosis pyrazinamidase function based on structural stability, physicochemical and geometrical descriptors

Author

Supo-Escalante, Rydberg Roman, primary, Médico, Aldhair, additional, Gushiken, Eduardo, additional, Olivos-Ramírez, Gustavo E., additional, Quispe, Yaneth, additional, Torres, Fiorella, additional, Zamudio, Melissa, additional, Antiparra, Ricardo, additional, Amzel, L. Mario, additional, Gilman, Robert H., additional, Sheen, Patricia, additional, and Zimic, Mirko, additional

Published
2020
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7. Cough dynamics in adults receiving tuberculosis treatment

Author

Lee, Gwenyth O., primary, Comina, Germán, additional, Hernandez-Cordova, Gustavo, additional, Naik, Nehal, additional, Gayoso, Oscar, additional, Ticona, Eduardo, additional, Coronel, Jorge, additional, Evans, Carlton A., additional, Zimic, Mirko, additional, Paz-Soldan, Valerie A., additional, Gilman, Robert H., additional, and Oberhelman, Richard, additional

Published
2020
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9. Automatic classification of pediatric pneumonia based on lung ultrasound pattern recognition

Author

Correa, Malena, primary, Zimic, Mirko, additional, Barrientos, Franklin, additional, Barrientos, Ronald, additional, Román-Gonzalez, Avid, additional, Pajuelo, Mónica J., additional, Anticona, Cynthia, additional, Mayta, Holger, additional, Alva, Alicia, additional, Solis-Vasquez, Leonardo, additional, Figueroa, Dante Anibal, additional, Chavez, Miguel A., additional, Lavarello, Roberto, additional, Castañeda, Benjamín, additional, Paz-Soldán, Valerie A., additional, Checkley, William, additional, Gilman, Robert H., additional, and Oberhelman, Richard, additional

Published
2018
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10. Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru

Author

Grandjean, Louis, primary, Gilman, Robert H., additional, Iwamoto, Tomatada, additional, Köser, Claudio U., additional, Coronel, Jorge, additional, Zimic, Mirko, additional, Török, M. Estee, additional, Ayabina, Diepreye, additional, Kendall, Michelle, additional, Fraser, Christophe, additional, Harris, Simon, additional, Parkhill, Julian, additional, Peacock, Sharon J., additional, Moore, David A. J., additional, and Colijn, Caroline, additional

Published
2017
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13. The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru

Author

Grandjean, Louis, Iwamoto, Tomotada, Lithgow, Anna, Gilman, Robert H, Arikawa, Kentaro, Nakanishi, Noriko, Martin, Laura, Castillo, Edith, Alarcon, Valentina, Coronel, Jorge, Solano, Walter, Aminian, Minoo, Guezala, Claudia, Rastogi, Nalin, Couvin, David, Sheen, Patricia, Zimic, Mirko, Moore, David AJ, London School of Hygiene and Tropical Medicine (LSHTM), Imperial College London, Universidad Peruana Cayetano Heredia (UPCH), Kobe Institute of Health, Chuo-ku, Kobe, Japan, Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), DIRESA de Callao, Bellavista, Callao, Peru, Unidad Tecnica TB-MDR, Lima, Peru, Rensselaer Polytechnic Institute (RPI), Naval Medical Research Unit 6—Bellavista, Callao, Peru, Unité de la Tuberculose et des Mycobactéries - WHO Supranational TB Reference Laboratory, Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), This work was supported by the Wellcome Trust [Grant Numbers WT088559MA, 078067/Z/05/Z] (www.wellcome.ac.uk), and the Japanese Ministry of Health Science Research Grant (www.mhlw.go.jp) [Grant number H24-SHINKO-IPPAN-011] and an MEXT/JSPS KAKENHI Grant [Grant number 24590845].

Subjects
Adult, Male, Genotype, Drug Resistance, lcsh:Medicine, MIRU-VNTRs, Mycobacterium tuberculosis/drug effects/genetics/isolation & purification, Latin American Mediterranean (LAM) Lineage, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Drug Resistance, Bacterial, Peru, Tuberculosis, Multidrug-Resistant, Tuberculosis, Humans, purl.org/pe-repo/ocde/ford#3.01.05 [https], lcsh:Science, Spoligotyping, lcsh:R, Drug Resistance, Bacterial/genetics, Mycobacterium tuberculosis, Middle Aged, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, purl.org/pe-repo/ocde/ford#3.02.07 [https], Microbial Phylogeny, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, lcsh:Q, Tuberculosis, Multidrug-Resistant/epidemiology/microbiology, Coevolution, Research Article
Abstract

International audience; BACKGROUND:The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of tuberculosis.METHODS:To investigate the association of Mycobacterium tuberculosis bacterial genotype with drug-resistance. Drug susceptibility testing together with genotyping using both 15-loci MIRU-typing and spoligotyping, was performed on 2,139 culture positive isolates, each from a different patient in Lima, Peru. Demographic, geospatial and socio-economic data were collected using questionnaires, global positioning equipment and the latest national census.RESULTS:The Latin American Mediterranean (LAM) clade (OR 2.4, p

Published
2015

14. Morphological Characterization of Mycobacterium tuberculosis in a MODS Culture for an Automatic Diagnostics through Pattern Recognition

Author

Alva, Alicia, primary, Aquino, Fredy, additional, Gilman, Robert H., additional, Olivares, Carlos, additional, Requena, David, additional, Gutiérrez, Andrés H., additional, Caviedes, Luz, additional, Coronel, Jorge, additional, Larson, Sandra, additional, Sheen, Patricia, additional, Moore, David A. J., additional, and Zimic, Mirko, additional

Published
2013
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18. Comparative Gene Expression Analysis throughout the Life Cycle of Leishmania braziliensis: Diversity of Expression Profiles among Clinical Isolates

Author

Adaui, Vanessa, primary, Castillo, Denis, additional, Zimic, Mirko, additional, Gutierrez, Andres, additional, Decuypere, Saskia, additional, Vanaerschot, Manu, additional, De Doncker, Simonne, additional, Schnorbusch, Kathy, additional, Maes, Ilse, additional, Van der Auwera, Gert, additional, Maes, Louis, additional, Llanos-Cuentas, Alejandro, additional, Arevalo, Jorge, additional, and Dujardin, Jean-Claude, additional

Published
2011
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20. Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru

Author

Grandjean, Louis, Gilman, Robert H, Iwamoto, Tomatada, Köser, Claudio U, Coronel, Jorge, Zimic, Mirko, Török, M Estee, Ayabina, Diepreye, Kendall, Michelle, Fraser, Christophe, Harris, Simon, Parkhill, Julian, Peacock, Sharon J, Moore, David AJ, and Colijn, Caroline

Subjects
Adult, Male, Mycobacterium tuberculosis, Polymorphism, Single Nucleotide, 3. Good health, Young Adult, Genes, Bacterial, Drug Resistance, Multiple, Bacterial, Mutation, Peru, Tuberculosis, Multidrug-Resistant, Humans, Female, Phylogeny
Abstract

BACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic and preventive strategies. METHODS: Here, we use novel genome-wide analysis techniques to identify polymorphisms that are associated with drug resistance, adaptive evolution and the structure of the phylogenetic tree. A total of 471 samples from different patients collected between 2009 and 2013 in the Lima suburbs of Callao and Lima South were sequenced on the Illumina MiSeq platform with 150bp paired-end reads. After alignment to the reference H37Rv genome, variants were called using standardized methodology. Genome-wide analysis was undertaken using custom written scripts implemented in R software. RESULTS: High quality homoplastic single nucleotide polymorphisms were observed in genes known to confer drug resistance as well as genes in the Mycobacterium tuberculosis ESX secreted protein pathway, pks12, and close to toxin/anti-toxin pairs. Correlation of homoplastic variant sites identified that many were significantly correlated, suggestive of epistasis. Variation in genes coding for ESX secreted proteins also significantly disrupted phylogenetic structure. Mutations in ESX genes in key antigenic epitope positions were also found to disrupt tree topology. CONCLUSION: Variation in these genes have a biologically plausible effect on immunogenicity and virulence. This makes functional characterization warranted to determine the effects of these polymorphisms on bacterial fitness and transmission.

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