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Objective: To investigate the correlation between serum brain natriuretic peptide (BNP), 25 hydroxyvitamin d [25 (OH) D], galactose lectin-3 (Gal-3) and left ventricular diastolic function in patients with hypertensive disorders of pregnancy (HDP), and to analyze its effect on pregnancy outcome. Methods: 114 patients with HDP who were treated in our hospital from June 2019 to December 2021 were selected as the study group, including 39 cases of gestational hypertension group, 44 cases of mild preeclampsia group and 31 cases of severe preeclampsia group. In addition, 30 healthy pregnant women examined in our hospital in the same period were selected as the control group. The serum BNP, 25(OH) D, Gal-3 and left ventricular diastolic function were compared in each group, and the correlation between serum BNP, 25 (OH) D, Gal-3 and left ventricular diastolic function were analyzed. According to the pregnancy outcome, the patients were divided into 65 cases in the good pregnancy outcome group and 49 cases in the poor pregnancy outcome group. The clinical data of the two groups were collected. The influencing factors of poor pregnancy outcome in patients with HDP were analyzed by univariate analysis and multivariate Logistic regression. Results: There were significant difference in the levels of serum BNP, 25 (OH) D and Gal-3 in each group (P<0.05). With the increase of disease severity, the levels of serum BNP and Gal-3 in patients with HDP gradually increased, and the level of 25 (OH) D gradually decreased. There were significant differences in the peak velocity of early diastolic filling (E peak), late diastolic filling (A peak) and E / A among the groups (P<0.05). Pearson correlation analysis showed that the levels of serum BNP and Gal-3 in patients with HDP were negatively correlated with E peak and E / A (P<0.05), and positively correlated with A peak (P<0.05), serum 25 (OH) D was positively correlated with E peak and E / A (P<0.05), and negatively correlated with A peak (P<0.05). Multivariate Logistic regression analysis showed that systolic blood pressure 158.02 mmHg, diastolic blood pressure 104.32 mmHg, serum BNP406.42 ng/L, serum 25 (OH) D 14.94 g/L and serum Gal-316.17 ng/mL were the risk factors of poor pregnancy outcome of HDP(P<0.05).Conclusion: The abnormal increase of the levels of serum BNP and Gal-3, and the abnormal decrease of the level of 25 (OH) D in patients with HDP are the risk factors of poor pregnancy outcome in patients with HDP. The levels of the three are related to the left ventricular diastolic function. The detection of the levels of the three is helpful to the clinical judgment of pregnancy outcome. [ABSTRACT FROM AUTHOR]

To investigate the efficacy of 3D laparoscopic radical gastrectomy for advanced gastric cancer and its effect on serum exosome Dicer and Phosphatase and tensin homolog deleted on chromosome ten (PTEN). A total of 60 patients with advanced gastric cancer treated in our hospital from July 2018 to May 2021 were selected as the research subjects. According to 1:1 random envelope lottery, the patients were divided into 3D group and laparotomy group, with 30 patients in each group. The open group was treated with open surgery, and the 3D group was treated with 3D laparoscopic radical gastrectomy. The surgical indications, complications, visual analog scales (VAS) score and Dicer and PTEN expressions of the two groups were compared and analyzed. There were no difference in the operation time and the number of lymph node dissections compared between the two groups(P>0.05). The postoperative exhaust time, postoperative gastric tube removal time, surgical incision length, the amount of bleeding, postoperative hospital stay, and surgery in the 3D group were less than that of the open group (P<0.05). The incidence of complications such as anastomotic bleeding, anastomotic leakage, gastroparesis, incision infection, and venous thrombosis in the 3D group at 14 days after operation were lower than the open group (P<0.05). The VAS scores of the 3D group at 1 d, 7 d and 14 d after operation were lower than those of the open group (P<0.05). The relative expression levels of serum exosomes Dicer and PTEN at 14 d after operation in the two groups were higher than that at 1d before operation (P<0.05), the 3D group were higher than the open group (P<0.05). All patients were followed up until November 1, 2021. The average follow-up time were (17.92± 0.22) months. The recurrence rate of the 3D group were 3.33 %, which were lower than the 20.00 % of the open group (P<0.05). 3D laparoscopic radical gastrectomy for patients with advanced gastric cancer can promote the secretion of serum exosome Dicer and PTEN without increasing the complexity of surgery, and can also promote the recovery of patients, reduce complications, relieve patients' pain, and reduce the recurrence rate during follow-up. [ABSTRACT FROM AUTHOR]

Objective: The incidence of sleep disorders during pregnancy increases significantly compare to pre-pregnancy stage. Sleep disorders during pregnancy may lead to gestational diabetes, hyperglycemia, postpartum depression and other disease. This research is to study the effect that exercise during pregnancy can have on sleep disorders. Methods: A questionnaire survey was conducted on pregnant women who were treated in our hospital from January to March 2021. The general information, pregnancy status, living habits and exercise status of the pregnant women were collected. Based on the Pittsburgh Sleep Quality Index (PSQI), we are able to score the sleep quality of this group of pregnant women. After that, the group of women is split into 2 sub groups based on their daily average length of time spending on exercise: one with daily exercise time ≤ 30 minutes and the another with daily exercise time > 30 minutes; then to analyze the effect of exercise time during pregnancy on sleep quality. Pregnant women with sleep disorders received lifestyle modification instructions to increase the daily exercise time. After four weeks, we calculated the PSQI scores again. Results: Out of 320 questionnaires being distributed, 293 were being retrieved and proved to be valid. Among all of the 293 files, 238 fall into the category of average exercise time ≤ 30 minutes, and the average score on sleep quality is 5.88; on contrary, the rest 55 fall into the subgroup with exercise time > 30 minutes, whereat the score of sleep quality being 4.83. The difference in between of the two subgroups subject to the score on sleep quality are tested to be statistically significant. After increasing the time of exercise for pregnant women with sleep disorders, 24% of the subjects obtains improvement on their sleep quality. Conclusions: During pregnancy, pregnant women who exercise over 30 minutes on a daily basis are tended to have better sleep quality than those who exercise less than 30 minutes. Therefore, for those who experience sleep disorders during pregnancy, it is recommended for them to obtain more daily exercise (>30 minutes) in order to improve their sleep quality, thereby better off the perinatal outcome. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical characteristics and etiology of patients with chest pain and with normal coronary artery. Methods: From January 2019 to May 2021, 1283 patients who had chest pain and were suspected of coronary atherosclerotic heart disease and underwent coronary angiography in our hospital was retrospectively analyzed. Clinical datas such as the demographic data, risk factors were extracted and compared between patients with normal coronary angiography and abnormal normal coronary angiography. The etiology of chest pain in patients with normal coronary angiography was analyzed. Results: Finally, 91 patients with suspected coronary artery disease whose coronary angiography were generally normal were enrolled. Compared with 1192 patients with abnormal coronary angiography, 20.1% had no risk factor of cardiovascular diseases and 50.5% had a single high-risk factor in the normal coronary angiography group, which was significantly higher than the abnormal coronary angiography group. What's more, 28.6% patients had multiple risk factors in the normal coronary angiography group, which was significantly lower than that of the abnormal coronary angiography group(P<0.05). Among 91 patients suspected of coronary heart disease, 45 cases were cardiac neurosis(49.5%) and 12 cases were arrhythmia (13.2%). Conclusions: In clinical, many patients with chest pain have normal coronary angiography. Compared with patients with abnormal coronary arteries, these patients have fewer risk factors for coronary heart disease, the symptom of chest pain werecaused by other reasons, so we should emphasize the application of noninvasive examination methods in these patients. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)