Objective: To explore the diagnostic value of alphafetoprotein (AFP), blood rheology, hypersensitive C-reactive protein (hs-CRP) and other indicators in patients with early liver cancer. Methods: 115 patients with liver cancer diagnosed by surgery and pathology who were admitted to our hospital from May 2016 to May 2019 were classified as group A, 109 patients with other benign liver lesions were classified as group B, and 98 healthy patients during the same period of physical examination As the control group C, observe the levels of various indicators such as AFP, hemorheology and hypersensitivity C-reactive protein in the three groups. Results: The levels of AFP and hs-CRP in group A were significantly higher than those in the benign liver disease group in group B and the healthy control group in group C. AFP in group B was higher than that in group C. The difference between the groups was statistically significant (P<0.05). ), there was no significant difference in hs-CRP levels between group B and group C (P>0.05); group A patients had high, medium, and low shear viscosity, whole blood viscosity, hematocrit, hematocrit, and erythrocyte sedimentation rate. The K value of the equation, fibrinogen, erythrocyte aggregation index, and erythrocyte rigidity index were significantly higher than those in groups B and C. The erythrocyte sedimentation rate and erythrocyte sedimentation rate equation K values of patients in group B were significantly higher than those in group C, and the differences between the groups were statistically significant. Significance (P<0.05); The erythrocyte sedimentation rate K value, hematocrit, plasma viscosity and low-shear viscosity of whole blood in patients with liver cancer with higher TNM staging in group A were significantly higher than those with low TNM staging, and the difference was statistically significant ( P<0.05). Conclusion: The abnormal changes of AFP, hs-CRP combined with blood rheological indexes of patients can be used as a basis for distinguishing benign liver diseases and malignant tumors, and at the same time, it can improve the accuracy of diagnosis, and can be used in the clinical scope. [ABSTRACT FROM AUTHOR]