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Objective: To investigate the effect of remifentanil on the cognitive function and cerebral oxygen metabolism in patients with intracranial aneurysms after acute hypervolemic hemodilution（AHH）. Methods: A total of 92 patients, who underwent intracranial aneurysm clipping in Suining Central Hospital from May 2015 to December 2016, were selected and were randomly divided into study group（n=46） and control group（n=46）. The study group was treated with remifentanil, and the control group was treated with nitroglycerin. Mean arterial pressure（MAP） and heart rate（HR） of the patients in the two groups before AHH（T0）, after AHH（T1）, before lowering blood pressure（T2）, 30 min after lowering blood pressure（T3）, 5 min after aneurysm clipping（T4） were recorded. The arterial and venous blood oxygen saturation（SAO2, SjvO2）, arterial oxygen partial pressure（PAO2）, and arterial oxygen partial pressure（PjvO2）were counted at T2-T4 time points. The arterial oxygen content（CAO2）, internal jugular vein oxygen content（CjvO2）, arterial internal jugular bulb oxygen deficit（Da-jvO2）, arterial bulb lactate difference（VADL） and brain oxygen uptake rate（CERO2） were calculated.The cognitive functions of two groups were evaluated by the Mini Mental State Scale（MMSE） before operation, 3 d and 7 d after operation. Results: Compared with the T2 time point, the MAP was decreased significantly in the two groups at T3 and T4 time points（P<0.05）. The HR in the control group was increased significantly, but the HR in the study group was decreased significantly（P<0.05）. The SaO2 of the two groups was 100%. At T3 and T4 time points, SjvO2 and CjvO2 in the study group were significantly higher than those at T2 time point,which was higher than those in the control group, and the differences were statistically significant（P<0.05）; the Da-jvO2 and CERO2 were significantly lower than at T2 time point, which were lower than those in the control group,and the differences were statistically significant（P<0.05）. There were no significant differences in the PaO2, CaO2, PjvO2, VADL between the two groups（P>0.05）.There were no significant differences in MMSE scores between the two groups before operation, 3 d and 7 d after operation（P>0.05）; the MMSE scores of the two groups before operation and 7 d after operation were higher than those of the two groups 3 d after operation（P<0.05）. Conclusion: Remifentanil in the acute hypervolemic hemodilution with intracranial aneurysm clipping can effectively maintain the stability of hemodynamics of patients, at the same time,the rate of cerebral oxygen metabolism can be effectively controlled. Compared with nitroglycerin, remifentanil is superior in acute hypervolemic hemodilution, but there is no obvious improvement in cognitive function. [ABSTRACT FROM AUTHOR]

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Objective: To explore the clinical efficacy and safety of umbilical cord blood stem cell transplantation in the treatment of ischemic heart disease (IHD). Methods: A total of 130 patients with IHD, who were treated in Affiliated Hospital of North Sichuan Medical College from January 2011 to January 2013, were randomly divided into observation group(n=65) and control group(n=65). The control group was treated with routine medicine, while the observation group was treated with umbilical cord blood stemcell transplantation. The LVEDV, RVEDV, LVEF of two groups before and 3 months after treatment were compared,and the clinical effect and the improving status of life quality after the treatment were observed. Results: The excellent effect rate(49.23%) and total effect rate(90.77%) of observation group after treatment were significantly higher than that(30.77%) and (70.77%) of control group, the differences were statistically significant (P<0.05). There were no statistical differences in LVEDV, RVEDV and LVEF between the two groups before treatment, but compared with control group, the LVEDV and RVEDV of observation group markedly decreased, LVEF increased after treatment, the differences were statistically significant (all P<0.05). The body functions, exercise limitation and overall health score of observation group were higher than those of control group after treatment, and the differences were statistically significant (all P<0.05). Conclusion: Umbilical cord blood stem cell transplantation has a good effect and high safety in the treatment of patients with IHD, which can significantly improve the heart function and the quality of life, and is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)