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Objective: To investigate the relationship between long non-coding ribonucleic acid (LncRNA) FTX, RHPN1-AS1 expression and prognosis in glioma tissue. Methods: A total of 105 cases of glioma patients in our hospital were selected from the surgically resected cancerous tissues and adjacent cancerous tissues (3~5cm from the tumor edge). Real-time quantitative reverse transcription PCR (qRT-PCR) was used to detect the expression of LncRNA FTX and RHPN1-AS1 in tissues. The relationship between LncRNA FTX and RHPN1-AS1 expression and clinicopathological features of glioma were analyzed. The 5-year progression-free survival time and overall survival time of glioma patients with different LncRNA FTX and RHPN1-AS1 expression were plotted by K-M method. Factors influencing poor prognosis in glioma patients were analyzed by Cox regression. Results: LncRNA FTX, RHPN1-AS1 expression levels in glioma tissues was higher than those in adjacent tissues(P＜0.05). LncRNA FTX, RHPN1-AS1 expression was correlated with Karnofsky Performance Status (KPS) score and World Health Organization (WHO) classification in glioma patients (P＜0.05). Progression-free survival time and overall survival time were shorter in the LncRNA FTX, RHPN1-AS1 high expression group than those in the low expression group (P＜0.05). KPS score (HR=2.621, 95%CI: 1.284～5.348), WHO classification (HR=2.264, 95%CI: 1.152～4.449), LncRNA FTX (HR=1.997, 95%CI: 1.017～3.922), and LncRNA RHPN1-AS1 (HR=2.431, 95%CI: 1.257～4.701) were influence factors for poor prognosis in glioma patients (P＜0.05). Conclusions: The expression levels of LncRNA FTX and RHPM1-AS1 in glioma tissues were increased, and both of them, KPS score and WHO grade were factors influencing the poor prognosis of patients, which could be used to evaluate the prognosis of glioma patients. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The application of dexmedetomidine combined with dezocine in the brachial plexus block anesthesia and its effect on the expression of serum VEGF, IL-6, IL-10 influence. Methods: 90 cases of upper extremity fracture fixation in our hospital fromMarch 2015 to August 2017 were selected as the study subjects and randomly divided into control group and combination group, 45 cases in each group. The control group in the brachial plexus block before the implementation of 10 minutes of continuous infusion of dexmedetomidine combined group based on assisted intravenous injection of dezocine. The intermusculus brachial plexus block was followed by ultrasound guidance. Comparative analysis of two groups of patients before brachial plexus anesthesia (T0), drug injection after minute (T1), [what started? For specific time points, surgical skin incision (T2), operative operation 5 minutes (T3), operation 30 minutes (T4) and end of operation (T5) at different time points, including hemodynamics, Ramsay sedation score, VEGF, IL-6 and IL-10 levels. Results: The combined group T1~T5 time MAP (blood pressure), HR (heart rate) were lower than the control group (P<0.05); two SpO2 (oxygen saturation) there is no significant difference between each time points (P>0.05); group T1~T5 time Ramsay sedation score of observation group was significantly higher than that in group two(P<0.05); T1~T5 VEGF time increased, and the combination group at each time point was significantly higher than that of the control group (P<0.05); 24 hours after operation, the level of IL-10 and IL-6 in combined group was significantly lower than the control group (P<0.05); combined anesthesia onset time was significantly shorter than the control group (P<0.05), The duration of analgesia, the duration of sensory nerve and motor nerve block were significantly longer than those of the control group(P<0.05). Concluvion: During the operation of upper limbs, the combination of dexmedetomidine and dezocine in brachial plexus block anesthesia has obvious analgesic effect and at the same time can effectiely stimulate the secretion of VEGF and decrease the levels of IL-6 and IL-10, Accelerate the recovery of patients after surgery. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study die effect of triamcinolone acetonide on the tumor necrosis factor (TNF)-α, interleukin (IL) -1β and H-6 levels in the aqueous fluid of patients after age-related cataract surgery Methods: 92 patients with age-related cataract who were treated from June 2014 to June 2016 in our hospital were selected and divided into the observation group (n=46) and the control group (n=46) according to the random number table. All the patients underwent phacoemulsification combined with intraocular lens implantation. The observation group was injected with triamcinolone acetonide in the anterior chamber after IOL implantation, the control group was injected with compound balanced salt solution, at 24h postoperation, pranoprofen Eye Drops was used, continuous medication was treated for 1 months. The changes of intraocular pressure, comeal endothelial cell count, uncorrected visual acuity, best corrected visual acuity-, ocular signs and inflammatory factors were compared between the two groups before and at 7 days after operation, the anterior chamber reaction at 1 day and 7 days postoperation and the incidence of adverse reactions were compared between two groups Results: There was no significant change in the intraocular pressure and corneal endothelial cell count before and after operation between the two groups (P >0.05); after operation, the uncorrected visual acuity, best corrected visual acuity and ocular signs score of both groups were significantly improved(P<0.05). the uncorrected visual acuity, the best corrected visual acuity and the integral of ocular signs of observation group were significantly better than those of the control group (P<0.05); compared with preoperation, the TNF-α, IL-1β and TL-6 levels in the aqueous fluid were significantly decreased (P<0.05), the levels of TNF-α, IL-1β and TL-6 m the aqueous fluid of observation group were significantly lower than those of the control group (P<0.05); the anterior chamber reaction of observation group at 1 day and 7 days after the operation were higher than those of the control group 3t 1 grade the 3 and the 4 grade of the anterior chamber reaction were lower than those of the control group (P 0.05); the incidence of adverse reactions in the observation group was significantly lower than that of the control group(P 0.05). Conclusion: Triamcinolone acetonide anterior chamber injecaon is effective foe age-related cataract patients after surgery, which can effectively alienate the postoperative anterior uveitis, reduce the complications and promote the postoperative visual recovery, which may be related to the inhibition of the expressions of TNF-α, IL-1 pand E-6 in the aqueous fluid. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)