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Objective: To explore the sedative effect of sleep deprivation combined with modified chloral hydrate retention enema in infants and young children’s pulmonary function examination. Methods: Prospectively selected the clinical data of infants and young children who were admitted to our hospital from February 2018 to August 2020 and required pulmonary function tests. 194 infants and young children were included as the research objects, and they were simply randomly divided into 4 groups according to the random number table method. The control group（n=48） did not undergo sleep deprivation, the short-term group（n=48） was short-term sleep deprivation, the middle-term group（n=49） the middle-term sleep deprivation, the long-term group（n=49） was the leader period sleep deprivation. The time to fall asleep, sedative effects and adverse reactions of the 4 groups of infants and young children were compared.Results: The difference in time to fall asleep between the four groups of infants and young children was statistically significant（P<0.05）.Compared with the control group, the number of infants and young children in the three groups of combined sleep deprivation intervention that went to sleep within 10 minutes was significantly increased; with the increase in sleep deprivation, the number of infants and young children in the three groups of sleep deprivation that went to sleep after 30 minutes was significantly less than the control group.The difference in the sedative effect of the four groups of infants and young children was statistically significant（P<0.05）; compared with the control group, the three groups of infants and young children combined with sleep deprivation intervention had a significantly higher sedative effect, and the total effective rate of sedation was higher than that of the control group（P<0.05）. During the experiment, the four groups of infants and young children had different types of adverse reactions, and there was no statistically significant difference in the incidence and total incidence of each type of adverse reaction among the groups（P>0.05）, but the the proportion of emotional irritability in the long-term group was slightly higher. Conclusion: Sleep deprivation combined with the modified chloral hydrate retention enema has a good sedative effect on infants and young children, but long-term sleep deprivation may make them emotionally irritable, so they need to be carefully calmed after the examination. [ABSTRACT FROM AUTHOR]

Objective: To observe the effect of dexmedetomidin and propofol on postoperative sedative effect and delirium in patients undergoing hip fracture surgery. Methods: 108 patients who underwent hip fracture surgery in our hospital from April 2016 to March 2018 were selected as the research object. The patients were divided into the observation group(n=54) and the control group(n=54) according to the random number table, total body intravenous anesthesia was used in the two group, the patients in the observation group were given sedation induced by dexmedetomidine, the patients in the control group were given sedation induced by propofol. 24 h after operation, Ramsay sedation score was used to evaluate the sedative effect of the two groups after operation, the visual analogue scale(VAS) score was used to evaluate the effect of postoperative analgesia. 1 week after operation, the incidence of postoperative delirium, delirium Rating Scale(CAM) score, mini mental state examination scale(MMSE) score were compared between the two groups. The occurrence of adverse reactions was recorded. Results: 24 h after operation, the Ramsay sedation score in the observation group was higher than that in the control group, and the VAS score and the dosage of analgesics were lower than those in the control group, the differences were statistically significant(P<0.05). 1 weeks after the operation, the incidence of delirium in the observation group and the CAM score were lower than those in the control group, and the MMSE score was higher than that of the control group, the differences were statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 9.26%, compared with14.81% of the control group, the difference was not statistically significant(P >0.05). Conclusion: Compared with propofol,dexmedetomidine can achieve better sedative, analgesic effects and reduce the incidence of delirium in patients with hip fracture surgery,there is no serious adverse reaction and high clinical value. [ABSTRACT FROM AUTHOR]

Objective: To investigate the sedative effect of dexmedetomidine combined with midazolam in craniocerebral trauma and its influence on neuroendocrine function. Methods: 82 patients with craniocerebral trauma treated in our hospital from March 2015 to May 2016 were selected. They were randomly divided into control group(n=41) and observation group(n=41). The control group received propofol and dexmedetomidine sedation, the observation group received dexmedetomidine combined with midazolam sedation.The sedation efficiency within twenty-four hours, medical expenses within one day sedation were compared between the two groups. The respiratory and circulatory function changes, serum cortisol, β-endorphin levels, peripheral blood leukocyte count and blood glucose levels before and after treatment were compared between the two groups. Results: The medical expenses within one day sedation in the observation group were lower than that in the control group, the difference was statistically significant(P<0.05). There was no statistical difference in the sedation efficiency between the two groups(P>0.05). After treatment, the average arterial pressure(MAP), heart rate(HR) and respiratory rate(RR) of the observation group were significantly higher than those in the control group, the differences were statistically significant(P<0.05). There was no statistical difference in blood oxygen saturation(SpO2), central venous pressure(CVP) between the two groups(P>0.05). After treatment, the serum cortisol, β-endorphin in the two groups were lower than before treatment. The serum cortisol, β-endorphin in observation group were higher than that in control group, the differences were statistically significant(P<0.05). After treatment, the peripheral blood leukocyte count and blood glucose in observation group were lower than before treatment. The blood glucose in control group was lower than before treatment. The peripheral blood leukocyte count in observation group was lower than that in control group, the differences were statistically significant(P<0.05). Conclusion: Dexmedetomidine combined with midazolam is effective in the treatment of craniocerebral trauma. It can effectively control the excessive stress reaction after craniocerebral trauma, and reduce the neuroendocrine system disorder and medical expenses, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To explore the sedative effect of hydrochloride dexmedetomidine combine with remifentanil in the orthopedics surgery and its influence on hemodynamics and respiratory function. Methods: A total of 186 patients, who underwent orthopedics surgery in Tangshan People’s Hospital from March 2016 to May 2017, were selected and randomly divided into observation group（93 cases） and control group（93 cases）. The control group received propofol combined with remifentanil for anesthesia; the observation group received hydrochloride dexmedetomidine combined with remifentanil for anesthesia. The sedative effect between the two groups before treatment（T1）, 10 min after combined use of drugs（T2）, 20 min after combined use of drugs（T3）, 30 min after combined use of drugs（T4） and after the patients were conscious（T5） and hemodynamics and respiratory function were compared, and the incidence of adverse reactions was compared between the two groups. Results: The Alertness/sedation（OAA/S） scores of the two groups at T3 and T4 time points were lower than those at other time points in the two group, and the OAA/S score of the observation group was lower than that of the control group（P<0.05）. There were no significant differences in respiratory rate（RR） and oxygen saturation（SpO2） between the two groups at T1 and T5 time points（P>0.05）. At the time of T2, T3 and T4, the RR and SpO2 of the observation group were higher than those of the control group（P<0.05）. The RR levels of the two groups at T3 and T4 time points were lower than those of the other time points（P<0.05）. There were no significant differences in mean arterial pressure（MAP） and heart rate（HR） between the two groups at each time point（P>0.05）. The incidence of respiratory depression, respiratory tract infarction and nausea and vomiting in the observation group was lower than that in the control group（P<0.05）. Conclusion: Hydrochloride dexmedetomidine combined with remifentanil has a good sedative effect in the orthopedics surgery, with less influence on hemodynamics, mild respiratory depression and good safety. [ABSTRACT FROM AUTHOR]

Objective: To explore the sedative effect and safety of dexmedetomidine for patients on the acute aggravating chronic obstructive pulmonary disease(AECOPD) under mechanical ventilation. Methods: 62 patients with tracheal intubation respirator assisted ventilation, who were treated in our hospital from June 2012 to September 2014, were selected and randomly divided into the experimental group and the control group. The patients in the control group were treated with the conventional method, while the patients in the experimental group were treated with dexmedetomidine besides of the conventional treatment. Then the time of mechanical ventilation and the incidence of the ventilator associated pneumonia(VAP) and delirium of patients in the two groups were observed and compared. Results: The mechanical ventilation time and ICU stay of patients in the experimental group were shorter than those of the control group with statistically significant differences(P<0.05); the incidences of VAP, bradycardia and delirium of patients in the experimental group were lower than those of the control group with statistically significant differences(P<0.05). Conclusions: Dexmedetomidine had better sedative effect and higher safety for the patients with AECOPD under mechanical ventilation. [ABSTRACT FROM AUTHOR]