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Objective:To explore and analysis the efficacy of early fluid resuscitation and intervention of protein plasma products in severe pancreatitis. Methods: From July 2018 to April 2021, 94 cases of patients with severe pancreatitis were selected to be diagnosed and treated in this hospital. All the cases were divided into the study group and control group with 47 cases each groups accorded to the random number 1:1 grouping method. The control group were given conventional early fluid resuscitation treatment, and the study group were given protein plasma product treatment on the basis of the treatment of the control group. All patients were treated and observed for 5 days. Compared and recorded the changes in the prognosis of the two groups of patients. Results: The incidence of complications and mechanical ventilation in study group was different with control group(P<0.05); The blood lactate value of the two treatment groups after treament were lower than before treatment, and the lactate clearance rate were higher than before treatment, the difference between the study group and the control group were also significance (P<0.05); The SOFA score and APACHE Ⅱ score after treatment in the two groups were lower than before treatment, and the study group were lower than the control group (P<0.05); The levels of platelets and hemoglobin after treatment in the group were lower than before treatment, and the levels of the study group were different with control group(P<0.05). Conclusion: The application of early fluid resuscitation combined with protein plasma product intervention in severe pancreatitis can improve the patient's condition and blood lactic acid status, help the platelet and hemoglobin levels to return to normal, thereby reducing the incidence of complications and mechanical ventilation in patients. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of continuous blood purification and enteral nutrition in the treatment of patients with severe pancreatitis and their influence on the levels of inflammatory factors. Methods: A total of 82 patients with severe pancreatitis who were treated in our hospital from January 2018 to December 2019 were selected as the research objects, and they were divided into a study group (49 cases) and a control group (33 cases) according to different treatment methods. Patients in the control group received only continuous blood purification, and patients in the study group received enteral nutrition support on the basis of patients in the control group. The patients in the two groups were compared with abdominal pain relief time, infection incidence, hospital stay, and blood urea nitrogen before and after treatment. BUN), creatinine (SCr), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), Changes in the scores of acute physiology and chronic health evaluation (APACHE Ⅱ). Results: The time to relieve abdominal pain, the incidence of infection, and the length of stay in the study group were shorter than those in the control group (P<0.05). After treatment, the APACHE Ⅱ score, serum CRP, IL-6, TNF-α, BUN and SCr levels in the study group were lower than those in the control group (P<0.05). Conclusion: Continuous blood purification combined with enteral nutrition support has a good therapeutic effect on patients with severe pancreatitis, which can significantly accelerate the outcome of patients with severe pancreatitis, and improve the renal injury and inflammation of the body. [ABSTRACT FROM AUTHOR]

Objective: To study the effects of continuous blood purification on inflammatory factors, endotoxin and intestinal mucosal barrier function in patients with severe acute pancreatitis. Methods: From February 2014 to January 2015, 86 patients with severe pancreatitis were divided into the observation group (43 cases) and the control group (43 cases) according to coin method. The control group was treated with conventional therapy, and the observation group was treated with continuous blood purification on the basis of control group. Then the changes of inflammatory factors, endotoxin and intestinal mucosal barrier function were compared between the two groups before and after treatment, and the relief time of clinical symptom of two groups was analyzed. Results: The serum levels of IL-6, IL-8, IL-lp, and TNF-a in the observation group were significantly higher than those in the control group (P <0. 05). The levels of endotoxin, D-lactate and diamine oxidase in the observation group were significantly lower than those in the control group(P<0.05). The relieving time of tenderness, abdominal pain and bloating in the observation group was significantly shorter than that in the control group (P <0.05). Conclusion: Continuous blood purification could effectively improve the levels of inflammatory factors, endotoxin and intestinal mucosal barrier function in patients with severe acute pancreatitis, and promote the rapid recovery of clinical symptoms in patients with severe acute pancreatitis. [ABSTRACT FROM AUTHOR]