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The review is devoted to erythema nodosum (UE), which is a typical variant of septal panniculitis without vasculitis and is a nonspecific immune inflammatory syndrome. Often, UE acts as one of the symptoms of systemic pathology, including rheumatic diseases (RH), sarcoidosis, Crohn’s disease, ulcerative colitis, cancer, etc., which can cause late diagnosis and, accordingly, the appointment of adequate therapy.