1. Efficacy and safety of amtolmetin guacil in the therapy of osteoarthritis and associated dyspepsia in routine clinical practice: agatha
- Author
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L. N. Denisov, E. S. Tsvetkova, E. N. Otteva, A. N. Dubikov, S. P. Yakupova, O. N. Ivanova, N. I. Korshunov, А. P. Vaisberg, R. A. Abyshev, А. V. Tartynov, and E. L. Nasonov
- Subjects
knee joint osteoarthrosis ,amtolmetine guacil ,dyspepsia ,Medicine - Abstract
Objective. To assess the efficacy and safety of amtolmetin guacil (AMG) in patients with knee joint osteoarthritis (KJOA) and associated dyspepsia in real clinical practice.Methods. 220 patients with KJOA with severe pain syndrome in KJ ≥ 40 mm in VAS and dyspepsia were included in the observation study. AMG was administered at a dose of 600 mg twice daily for 28 days. Patients had three visits: before starting treatment, on Day 14 ± 3 (visit 2), on Day 28 ± 3 (final visit) to assess the pain dynamics (according to VAS), stiffness and functional activity according to WOMAC index, general health assessment (according to VAS) and a quantitative assessment of dyspepsia (SODA index).Results. Of 219 patients, about 72.5% reported pain reduction from 65 to 27 mm at the end of the study. All indicators of three scales of the WOMAC index decreased statistically significant (р
- Published
- 2018
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