1. Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages
- Author
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Amirhossein Modabbernia, Didac Vidal-Pineiro, Ingrid Agartz, Ole Andreassen, Rosa Ayesa-Arriola, Alessandro Bertolino, D Boomsma, Josiane Bourque, Alan Breier, Henry Brodaty, Rachel Brouwer, Jan Buitelaar, Erick Canales-Rodriguez, Xavier Caseras, Patricia Conrod, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline Crone, Greig De Zubicaray, Erin Dickie, Danai Dima, Thomas Espeseth, Stefan Frenzel, Simon Fisher, Barbara Franke, David Glahn, Hans Grabe, Dominik Grotegerd, Oliver Gruber, Amalia Guerrero-Pedraza, Raquel Gur, Ruben Gur, Catharina Hartman, Pieter Hoekstra, Hilleke Hulshoff Pol, Neda Jahanshad, Terry Jernigan, Jiyang Jiang, Andrew Kalnin, Nicole Kochan, Bernard Mazoyer, Brenna McDonald, Katie McMahon, Lars Nyberg, Jaap Oosterlaan, E Pomarol-Clotet, Joaquim Radua, Joshua Roffman, Perminder Sachdev, Theodore Satterthwaite, Raymond Salvador, Salvador Sarró, Andrew Saykin, Gunter Schumann, Jordan Smoller, Iris Sommer, Christian Tamnes, Sophia Thomopoulos, Julian Trollor, Dennis van 't Ent, Aristotle Voineskos, Yang Wang, Bernd Weber, Wei Wen, Lars T. Westlye, Heather Whalley, Lara wierenga, Steven Williams, Katharina Wittfeld, Margaret Wright, Paul Thompson, Tomas Paus, and Sophia Frangou
- Abstract
Mechanisms underpinning neurotypical age-related variations in cortical thickness in the human brain remain insufficiently specified. Here we used cell-specific marker genes, followed by gene ontology and enrichment analyses, to quantify the association between gene-expression levels and inter-regional age-related variations in neurotypical cortical thinning using multicohort neuroimaging data from 14,248 individuals ages 4-89 years. We found that early-life (60 years) were associated with distinct patterns of association between inter-regional profiles of cortical thickness and expression profiles of markers genes for CA1 and S1 pyramidal cells, astrocytes, and microglia. Gene ontology and enrichment analyses indicated each of the three life-stages was associated with different biological processes and cellular components; these related to synaptic modeling in early life, neurotransmission in mid-life, and neurodegeneration in late-life. These findings provide mechanistic insights on age-related cortical thinning during typical development and ageing.
- Published
- 2022
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