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Obesity has been increasing in many regions of the world, including Europe, USA, and Korea. To manage obesity, we should consider it as a disease and apply therapeutic methods for its treatment. Molecular and therapeutic approaches for obesity management involve regulating biomolecules such as DNA, RNA, and protein in adipose-derived stem cells to prevent to be fat cells. Multiple factors are believed to play a role in fat differentiation, with one of the most effective factor is Ca2+. In particular, Ca2+ plays an important role in different stages of cell development and is introduced into it by various mechanisms, including calcium channels. We recently reported that the electromagnetic perceptive gene (EPG) regulated intracellular Ca2+ levels under various electromagnetic fields. This study aimed to investigate whether EPG could serve as a therapeutic method against obesity. We confirmed that EPG serves as a modulator of Ca2+ levels in primary adipose cells, thereby regulating serval genes during the adipogenesis. In addition, this study also identified EPG-mediated regulation of myogenesis that myocyte transcription factors were elevated in C2C12 cells and satellite cells. In conclusion, the in vitro and in vivo experiments carried out in this study indicates that owing to its regulatory function, EPG could serve as a potent therapeutic agent against obesity.