1. Associations of TLR4 and IL-8 genes polymorphisms with Age-related macular degeneration (AMD): a systematic review and meta-analysis
- Author
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Amin Khamaneh, Leila Vahedi, Elham Shahriyari, Sousan Mirjand Gerami, Nasrin Roshanipour, and Maryam Ghaffari Laleh
- Subjects
medicine.medical_specialty ,Gastroenterology ,Polymorphism, Single Nucleotide ,symbols.namesake ,Macular Degeneration ,Polymorphism (computer science) ,Risk Factors ,Internal medicine ,Genotype ,medicine ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,Allele ,Genetics (clinical) ,Genetic Association Studies ,business.industry ,Interleukin-8 ,Odds ratio ,Macular degeneration ,medicine.disease ,Confidence interval ,Toll-Like Receptor 4 ,Ophthalmology ,Bonferroni correction ,Meta-analysis ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,symbols ,business - Abstract
BackgroundThe results of different studies have indicated the possible associations of TLR4 and IL-8 genes polymorphisms with Age-Related Macular Degeneration (AMD). A meta-analysis study was designed to evaluate the possible associations of TLR4 and IL-8 genes polymorphisms with Age-Related Macular Degeneration (AMD). MethodA systematic literature search was carried out in PubMed, Embase, Web of Science, and Scopus databases to identify relevant publications. Pooled Odds Ratio (OR) with 95% Confidence Interval (CI) was used to evaluate the power of association.ResultsA total of 12 case-control studies with 4804 AMD patients and 4422 healthy controls were included in this meta-analysis. We found significant associations under the genotypic and allelic models of TLR4/rs4986790 (AA vs. AG+GG: OR=0.73 [0.55-0.97], P=0.03; and AA vs. AG: OR=0.71 [0.53-0.95], P=0.02) and IL-8/rs2227306 (TT vs. CC: OR=1.63 [1.04-2.56], P=0.03; CC vs. TT+TC: OR=0.62 [0.48-0.80], PP=0.007; and C vs. T: OR=0.71 [0.64-0.78], P
- Published
- 2020