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Purpose. The purpose of this study was to estimate radiation-induced nausea (RIN) prevalence and severity among 183 women with early-stage breast cancer and to identify its predictors. Methods. Among participants who underwent radiotherapy, a case-control design compared those who experienced RIN to those who did not. Nausea was measured weekly and operationalized on an 11-point scale with ‘0’ representing “no nausea” and ’10’ representing the “worst nausea ever experienced.” Participants self-reported these symptoms while undergoing radiotherapy. Predictor variables were identified using multivariable binary logistic regression for RIN prevalence and multiple linear regression for RIN severity. Results. Over forty percent (n=75) of participants undergoing radiotherapy experienced RIN, with a mean nausea severity rating of 3.27/10. Significant predictors of RIN prevalence were higher pain levels (pConclusions. The RIN prevalence of 41.0 percent among study participants was higher than previously reported for patients undergoing breast radiotherapy. This could be due to the collection of weekly self-reported data that quantified RIN severity. Younger age, history of nausea, and higher average pain levels should be identified as potential RIN risk factors among patients with early-stage breast cancer. Risk factor identification at the onset of radiotherapy would allow for increased prophylactic mitigation of RIN.