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Your search keyword '"Hibbs, M. L."' showing total 4 results
Start Over Author "Hibbs, M. L." Publisher rockefeller university press
4 results on '"Hibbs, M. L."'

4. Inhibition of the B cell by CD22: a requirement for Lyn.

Author

Smith KG, Tarlinton DM, Doody GM, Hibbs ML, and Fearon DT

Subjects
Amino Acid Sequence, Animals, Calcium physiology, Immune Tolerance, Intracellular Signaling Peptides and Proteins, Mice, Mice, Knockout, Phosphorylation, Phosphotyrosine metabolism, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Sialic Acid Binding Ig-like Lectin 2, Signal Transduction, Spleen cytology, Antigens, CD physiology, Antigens, Differentiation, B-Lymphocyte physiology, Autoimmunity, B-Lymphocytes physiology, Cell Adhesion Molecules, Lectins, Protein Tyrosine Phosphatases physiology, Receptors, Antigen, B-Cell physiology, src-Family Kinases physiology
Abstract

Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice.

Published
1998
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