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Your search keyword '"Roychoudhuri, Rahul"' showing total 6 results
Start Over Author "Roychoudhuri, Rahul" Publisher rockefeller university press
6 results on '"Roychoudhuri, Rahul"'

1. BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

Author

Imianowski, Charlotte J., primary, Whiteside, Sarah K., additional, Lozano, Teresa, additional, Evans, Alexander C., additional, Benson, Jayme D., additional, Courreges, Christina J.F., additional, Sadiyah, Firas, additional, Lau, Colleen M., additional, Zandhuis, Nordin D., additional, Grant, Francis M., additional, Schuijs, Martijn J., additional, Vardaka, Panagiota, additional, Kuo, Paula, additional, Soilleux, Elizabeth J., additional, Yang, Jie, additional, Sun, Joseph C., additional, Kurosaki, Tomohiro, additional, Okkenhaug, Klaus, additional, Halim, Timotheus Y.F., additional, and Roychoudhuri, Rahul, additional

Published
2022
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2. BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression

Author

Grant, Francis M., primary, Yang, Jie, primary, Nasrallah, Rabab, primary, Clarke, James, primary, Sadiyah, Firas, primary, Whiteside, Sarah K., primary, Imianowski, Charlotte J., primary, Kuo, Paula, primary, Vardaka, Panagiota, primary, Todorov, Tihomir, primary, Zandhuis, Nordin, primary, Patrascan, Ilinca, primary, Tough, David F., primary, Kometani, Kohei, primary, Eil, Robert, primary, Kurosaki, Tomohiro, primary, Okkenhaug, Klaus, primary, and Roychoudhuri, Rahul, primary

Published
2020
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3. Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection

Author

Omilusik, Kyla D., primary, Best, J. Adam, additional, Yu, Bingfei, additional, Goossens, Steven, additional, Weidemann, Alexander, additional, Nguyen, Jessica V., additional, Seuntjens, Eve, additional, Stryjewska, Agata, additional, Zweier, Christiane, additional, Roychoudhuri, Rahul, additional, Gattinoni, Luca, additional, Bird, Lynne M., additional, Higashi, Yujiro, additional, Kondoh, Hisato, additional, Huylebroeck, Danny, additional, Haigh, Jody, additional, and Goldrath, Ananda W., additional

Published
2015
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4. Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

Author

Palmer, Douglas C., primary, Guittard, Geoffrey C., additional, Franco, Zulmarie, additional, Crompton, Joseph G., additional, Eil, Robert L., additional, Patel, Shashank J., additional, Ji, Yun, additional, Van Panhuys, Nicholas, additional, Klebanoff, Christopher A., additional, Sukumar, Madhusudhanan, additional, Clever, David, additional, Chichura, Anna, additional, Roychoudhuri, Rahul, additional, Varma, Rajat, additional, Wang, Ena, additional, Gattinoni, Luca, additional, Marincola, Francesco M., additional, Balagopalan, Lakshmi, additional, Samelson, Lawrence E., additional, and Restifo, Nicholas P., additional

Published
2015
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5. Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells

Author

Klebanoff, Christopher A., primary, Spencer, Sean P., additional, Torabi-Parizi, Parizad, additional, Grainger, John R., additional, Roychoudhuri, Rahul, additional, Ji, Yun, additional, Sukumar, Madhusudhanan, additional, Muranski, Pawel, additional, Scott, Christopher D., additional, Hall, Jason A., additional, Ferreyra, Gabriela A., additional, Leonardi, Anthony J., additional, Borman, Zachary A., additional, Wang, Jinshan, additional, Palmer, Douglas C., additional, Wilhelm, Christoph, additional, Cai, Rongman, additional, Sun, Junfeng, additional, Napoli, Joseph L., additional, Danner, Robert L., additional, Gattinoni, Luca, additional, Belkaid, Yasmine, additional, and Restifo, Nicholas P., additional

Published
2013
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6. Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.

Author

Omilusik KD, Best JA, Yu B, Goossens S, Weidemann A, Nguyen JV, Seuntjens E, Stryjewska A, Zweier C, Roychoudhuri R, Gattinoni L, Bird LM, Higashi Y, Kondoh H, Huylebroeck D, Haigh J, and Goldrath AW

Subjects
Animals, CD8-Positive T-Lymphocytes metabolism, Cell Differentiation immunology, Flow Cytometry, Homeodomain Proteins genetics, Host-Pathogen Interactions immunology, Humans, Immunologic Memory immunology, Lectins, C-Type, Lymphocytic Choriomeningitis genetics, Lymphocytic Choriomeningitis virology, Lymphocytic choriomeningitis virus immunology, Lymphocytic choriomeningitis virus physiology, Male, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Oligonucleotide Array Sequence Analysis, Protein Binding immunology, Receptors, Immunologic immunology, Receptors, Immunologic metabolism, Repressor Proteins deficiency, Repressor Proteins genetics, Reverse Transcriptase Polymerase Chain Reaction, T-Box Domain Proteins immunology, T-Lymphocyte Subsets metabolism, Transcriptome genetics, Transcriptome immunology, Zinc Finger E-box Binding Homeobox 2, CD8-Positive T-Lymphocytes immunology, Homeodomain Proteins immunology, Lymphocytic Choriomeningitis immunology, Repressor Proteins immunology, T-Lymphocyte Subsets immunology
Abstract

ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early neurogenesis and in epithelial-mesenchymal transition-dependent tumor metastasis. Although the function of ZEB2 in T lymphocytes is unknown, activity of the closely related family member ZEB1 has been implicated in lymphocyte development. Here, we find that ZEB2 expression is up-regulated by activated T cells, specifically in the KLRG1(hi) effector CD8(+) T cell subset. Loss of ZEB2 expression results in a significant loss of antigen-specific CD8(+) T cells after primary and secondary infection with a severe impairment in the generation of the KLRG1(hi) effector memory cell population. We show that ZEB2, which can bind DNA at tandem, consensus E-box sites, regulates gene expression of several E-protein targets and may directly repress Il7r and Il2 in CD8(+) T cells responding to infection. Furthermore, we find that T-bet binds to highly conserved T-box sites in the Zeb2 gene and that T-bet and ZEB2 regulate similar gene expression programs in effector T cells, suggesting that T-bet acts upstream and through regulation of ZEB2. Collectively, we place ZEB2 in a larger transcriptional network that is responsible for the balance between terminal differentiation and formation of memory CD8(+) T cells., (© 2015 Omilusik et al.)

Published
2015
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