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Your search keyword '"Kozlovskaia, E. P."' showing total 3 results
Start Over Author "Kozlovskaia, E. P." Publisher rossiiskaia akademiia meditsinskikh nauk
3 results on '"Kozlovskaia, E. P."'

1. [Interaction investigation of trypsin inhibitor from sea anemone Radianthus macrodactylus with proteases].

Author

Sokotun IN, Gnedenko OV, Leĭchenko EV, Monastyrnaia MM, Kozlovskaia EP, Mol'nar AA, and Ivanov AC

Subjects
Animals, Humans, Kinetics, Peptide Hydrolases metabolism, Protein Binding, Sea Anemones metabolism, Trypsin Inhibitors isolation & purification, Trypsin Inhibitors metabolism, Peptide Hydrolases chemistry, Sea Anemones chemistry, Trypsin Inhibitors chemistry
Abstract

The interaction of inhibitor VJ (InhVJ), isolated from sea anemone R. macrodactylus, with different proteases was investigated. The following enzymes were tested: serine proteases (trypsin, alpha-chymotrypsin, plasmin, thrombin, kallikrein), cysteine protease (papain) and aspartic protease (pepsin). Inhibitor VJ interacted only with trypsin and 6-chymotrypsin. Kinetic and thermodynamics parameters of intermolecular complexes formation were determined: KD = 7,38 x 10(-8) M and 9,93 x 10(-7) M for pairs InhVJ/trypsin and InhVJ/alpha-chymotrypsin, respectively.

Published
2006

2. [Hepatoprotective properties of balm Herbamarin and hydrolysates from marine invertebrates in toxic hepatitis and ethanol intoxication].

Author

Burtseva TI, Semenova NV, Popov AM, Li IA, Veselova OB, and Kozlovskaia EP

Subjects
Animals, Brachyura, Carbon Tetrachloride Poisoning prevention & control, Chemical and Drug Induced Liver Injury etiology, Dietary Supplements, Hydrolysis, Liver metabolism, Liver physiopathology, Marine Biology, Mice, Mollusca, Plant Extracts therapeutic use, Alcoholic Intoxication prevention & control, Biological Products therapeutic use, Chemical and Drug Induced Liver Injury prevention & control, Liver drug effects
Abstract

Protective properties of a syrup balm "Herbamarin" and food hydrolysates of scallop, octopus and crab were investigated using experimental toxic hepatitis and ethanol intoxication. Preventive administration of the balm and hydrolysates to animals subjected to an intoxications by 40% alcohol and CCl4 normalized clinical-diagnostic parameters of liver and blood plasma of experimental animals.

Published
2005

3. [Effects of Gerbamarin T balms on functions of the cardiovascular and hepatobiliary systems].

Author

Popov AM, Burtseva TI, Li IA, Semenova NV, and Kozlovskaia EP

Subjects
Animals, Biliary Tract physiopathology, Carbon Tetrachloride Poisoning drug therapy, Carbon Tetrachloride Poisoning physiopathology, Cardiovascular System physiopathology, Chemical and Drug Induced Liver Injury drug therapy, Chemical and Drug Induced Liver Injury physiopathology, Cholesterol, Diet, Hypertension chemically induced, Hypertension drug therapy, Hypertension physiopathology, Invertebrates, Liver physiopathology, Mice, Obesity chemically induced, Obesity drug therapy, Obesity physiopathology, Oceans and Seas, Biliary Tract drug effects, Cardiovascular System drug effects, Liver drug effects, Plant Extracts pharmacology, Tissue Extracts pharmacology
Abstract

The effects two balms of "Herbamarin" T series on some parameters of cardiovascular and hepatobiliary systems were studied in mice either kept on the cholesterol diet or treated with CCl4. The results allow to recommend these balms as additional components to the therapy of various cardiovascular and hepatic diseases.

Published
2003

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