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Start Over Author "Monastyrnaia, M. M." Publisher rossiiskaia akademiia meditsinskikh nauk

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1 results on '"Monastyrnaia, M. M."'

1. [Interaction investigation of trypsin inhibitor from sea anemone Radianthus macrodactylus with proteases].

Author

Sokotun IN, Gnedenko OV, Leĭchenko EV, Monastyrnaia MM, Kozlovskaia EP, Mol'nar AA, and Ivanov AC

Subjects
Animals, Humans, Kinetics, Peptide Hydrolases metabolism, Protein Binding, Sea Anemones metabolism, Trypsin Inhibitors isolation & purification, Trypsin Inhibitors metabolism, Peptide Hydrolases chemistry, Sea Anemones chemistry, Trypsin Inhibitors chemistry
Abstract

The interaction of inhibitor VJ (InhVJ), isolated from sea anemone R. macrodactylus, with different proteases was investigated. The following enzymes were tested: serine proteases (trypsin, alpha-chymotrypsin, plasmin, thrombin, kallikrein), cysteine protease (papain) and aspartic protease (pepsin). Inhibitor VJ interacted only with trypsin and 6-chymotrypsin. Kinetic and thermodynamics parameters of intermolecular complexes formation were determined: KD = 7,38 x 10(-8) M and 9,93 x 10(-7) M for pairs InhVJ/trypsin and InhVJ/alpha-chymotrypsin, respectively.

Published
2006

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