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Research on women and depression has neglected to explore how the factors that put women at risk for depression apply to lesbians. The present study examined four of the risk factors consistently cited in the women and depression literature (relationship status, relationship satisfaction, social support from friends, and social support from family), and two unique factors (outness and relationship status satisfaction), to determine their ability to predict depression among lesbians. Data were collected from 167 lesbians between the ages of 20 and 60. Perceived social support from friends, relationship status satisfaction, and perceived social support from family, were found to be significant predictors, accounting for 17.8% of the variance in depression, as measured by the Center for Epidemiologic Study Depression Scale (CES-D). A second multiple regression equation focused on the 110 lesbians who were in committed relationships, using the variables relationship satisfaction, perceived social support from friends, perceived social support from family, and outness, to determine if relationship satisfaction added to the amount of variance which could be predicted in depression. Social support from friends was the only significant predictor in this equation, accounting for 5.8% of the variance in depression scores.